UniProtKB - P0AEN4 (FTSL_ECOLI)
Protein
Cell division protein FtsL
Gene
ftsL
Organism
Escherichia coli (strain K12)
Status
Functioni
Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. Can also mediate Zn2+-sensitivity probably by increasing the permeability of the inner membrane.UniRule annotation3 Publications
GO - Biological processi
- FtsZ-dependent cytokinesis Source: EcoCyc
Keywordsi
Biological process | Cell cycle, Cell division |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11086-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Cell division protein FtsLUniRule annotation |
Gene namesi | Name:ftsLUniRule annotation Synonyms:mraR, yabD Ordered Locus Names:b0083, JW0081 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Cell inner membrane UniRule annotation5 Publications; Single-pass type II membrane protein UniRule annotation5 Publications Note: Localizes to the division septum where it forms a ring structure. Localization requires FtsZ, FtsA, ZipA, FtsK, FtsQ and FtsB, but not FtsI and FtsN. Localization of FtsB and FtsL is codependent.
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 34 | CytoplasmicUniRule annotationAdd BLAST | 34 | |
Transmembranei | 35 – 57 | HelicalUniRule annotationAdd BLAST | 23 | |
Topological domaini | 58 – 121 | PeriplasmicUniRule annotationAdd BLAST | 64 |
GO - Cellular componenti
- cell division site Source: EcoCyc
- integral component of plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Mutants show inhibition of cell division, formation of long, nonseptate filaments, ultimate cessation of growth and lysis.1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 70 | L → H: Impairs both localization and function, and reduces the efficiency of dimerization. 1 Publication | 1 | |
Mutagenesisi | 84 | L → D: Impairs both localization and function, and reduces the efficiency of dimerization. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000087371 | 1 – 121 | Cell division protein FtsLAdd BLAST | 121 |
Proteomic databases
PaxDbi | P0AEN4 |
PRIDEi | P0AEN4 |
Interactioni
Subunit structurei
Part of a complex composed of FtsB, FtsL and FtsQ. The complex can be formed before its localization to the division site. This tripartite complex can be divided further into a subcomplex of FtsB and FtsL, which forms in the absence of FtsQ.
Interacts also with FtsI, FtsN and YmgF. Homodimer in vitro. May form multimers.
UniRule annotation5 PublicationsBinary interactionsi
Hide detailsP0AEN4
Protein-protein interaction databases
BioGRIDi | 4261638, 332 interactors 849204, 1 interactor |
ComplexPortali | CPX-3099, FtsQBL complex CPX-3299, FtsBL complex |
DIPi | DIP-47987N |
IntActi | P0AEN4, 17 interactors |
MINTi | P0AEN4 |
STRINGi | 511145.b0083 |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 63 – 91 | Sequence analysisAdd BLAST | 29 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 58 – 85 | Leucine zipper-likeAdd BLAST | 28 |
Domaini
The cytoplasmic region is involved in recruitment of the downstream cell division protein FtsW. The transmembrane segment and the membrane-proximal periplasmic region form a coiled-coil structure and are required for septal localization and interaction with FtsB. The C-terminal region is required for interaction with FtsQ. Contains a leucine zipper-like (LZ) motif, which is required for optimal interaction with FtsB.2 Publications
Sequence similaritiesi
Belongs to the FtsL family.UniRule annotation
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG3116, Bacteria |
HOGENOMi | CLU_156524_2_0_6 |
InParanoidi | P0AEN4 |
Family and domain databases
HAMAPi | MF_00910, FtsL, 1 hit |
InterProi | View protein in InterPro IPR011922, Cell_div_FtsL |
PANTHERi | PTHR37479, PTHR37479, 1 hit |
Pfami | View protein in Pfam PF04999, FtsL, 1 hit |
TIGRFAMsi | TIGR02209, ftsL_broad, 1 hit |
i Sequence
Sequence statusi: Complete.
P0AEN4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MISRVTEALS KVKGSMGSHE RHALPGVIGD DLLRFGKLPL CLFICIILTA
60 70 80 90 100
VTVVTTAHHT RLLTAQREQL VLERDALDIE WRNLILEENA LGDHSRVERI
110 120
ATEKLQMQHV DPSQENIVVQ K
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S49875 Genomic DNA Translation: AAB24309.1 S49802 Genomic DNA Translation: AAB24311.1 X55034 Genomic DNA Translation: CAA38860.1 U00096 Genomic DNA Translation: AAC73194.1 AP009048 Genomic DNA Translation: BAB96651.2 K00137 Genomic DNA Translation: AAA24299.1 X52063 Genomic DNA Translation: CAA36285.1 |
PIRi | A45278 |
RefSeqi | NP_414625.1, NC_000913.3 WP_000625658.1, NZ_STEB01000010.1 |
Genome annotation databases
EnsemblBacteriai | AAC73194; AAC73194; b0083 BAB96651; BAB96651; BAB96651 |
GeneIDi | 58460777 944803 |
KEGGi | ecj:JW0081 eco:b0083 |
PATRICi | fig|1411691.4.peg.2197 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S49875 Genomic DNA Translation: AAB24309.1 S49802 Genomic DNA Translation: AAB24311.1 X55034 Genomic DNA Translation: CAA38860.1 U00096 Genomic DNA Translation: AAC73194.1 AP009048 Genomic DNA Translation: BAB96651.2 K00137 Genomic DNA Translation: AAA24299.1 X52063 Genomic DNA Translation: CAA36285.1 |
PIRi | A45278 |
RefSeqi | NP_414625.1, NC_000913.3 WP_000625658.1, NZ_STEB01000010.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4261638, 332 interactors 849204, 1 interactor |
ComplexPortali | CPX-3099, FtsQBL complex CPX-3299, FtsBL complex |
DIPi | DIP-47987N |
IntActi | P0AEN4, 17 interactors |
MINTi | P0AEN4 |
STRINGi | 511145.b0083 |
Proteomic databases
PaxDbi | P0AEN4 |
PRIDEi | P0AEN4 |
Genome annotation databases
EnsemblBacteriai | AAC73194; AAC73194; b0083 BAB96651; BAB96651; BAB96651 |
GeneIDi | 58460777 944803 |
KEGGi | ecj:JW0081 eco:b0083 |
PATRICi | fig|1411691.4.peg.2197 |
Organism-specific databases
EchoBASEi | EB1078 |
Phylogenomic databases
eggNOGi | COG3116, Bacteria |
HOGENOMi | CLU_156524_2_0_6 |
InParanoidi | P0AEN4 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11086-MONOMER |
Miscellaneous databases
PROi | PR:P0AEN4 |
Family and domain databases
HAMAPi | MF_00910, FtsL, 1 hit |
InterProi | View protein in InterPro IPR011922, Cell_div_FtsL |
PANTHERi | PTHR37479, PTHR37479, 1 hit |
Pfami | View protein in Pfam PF04999, FtsL, 1 hit |
TIGRFAMsi | TIGR02209, ftsL_broad, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FTSL_ECOLI | |
Accessioni | P0AEN4Primary (citable) accession number: P0AEN4 Secondary accession number(s): P22187, Q8KMX6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | December 20, 2005 | |
Last modified: | February 10, 2021 | |
This is version 115 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families