Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Negative regulator of flagellin synthesis

Gene

flgM

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA.

GO - Molecular functioni

  • sigma factor antagonist activity Source: EcoCyc

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processBacterial flagellum biogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:G369-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Negative regulator of flagellin synthesis
Alternative name(s):
Anti-sigma-28 factor
Gene namesi
Name:flgM
Ordered Locus Names:b1071, JW1058
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12664 flgM

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000872831 – 97Negative regulator of flagellin synthesisAdd BLAST97

Proteomic databases

EPDiP0AEM4
PaxDbiP0AEM4
PRIDEiP0AEM4

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
fliAP0AEM64EBI-1121952,EBI-549807

Protein-protein interaction databases

IntActiP0AEM4, 13 interactors
STRINGi316385.ECDH10B_1142

Structurei

3D structure databases

ProteinModelPortaliP0AEM4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FlgM family.Curated

Phylogenomic databases

eggNOGiENOG4105M9M Bacteria
COG2747 LUCA
HOGENOMiHOG000265658
KOiK02398

Family and domain databases

InterProiView protein in InterPro
IPR035890 Anti-sigma-28_factor_FlgM_sf
IPR007412 FlgM
IPR031316 FlgM_C
PfamiView protein in Pfam
PF04316 FlgM, 1 hit
SUPFAMiSSF101498 SSF101498, 1 hit
TIGRFAMsiTIGR03824 FlgM_jcvi, 1 hit

Sequencei

Sequence statusi: Complete.

P0AEM4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSIDRTSPLK PVSTVQPRET TDAPVTNSRA AKTTASTSTS VTLSDAQAKL
60 70 80 90
MQPGSSDINL ERVEALKLAI RNGELKMDTG KIADALINEA QQDLQSN
Length:97
Mass (Da):10,341
Last modified:December 20, 2005 - v1
Checksum:i367D6F63324BF75D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19773 Genomic DNA Translation: AAA61762.1
U00096 Genomic DNA Translation: AAC74155.1
AP009048 Genomic DNA Translation: BAA35879.1
PIRiD64850
RefSeqiNP_415589.1, NC_000913.3
WP_000020880.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74155; AAC74155; b1071
BAA35879; BAA35879; BAA35879
GeneIDi946684
KEGGiecj:JW1058
eco:b1071
PATRICifig|1411691.4.peg.1197

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19773 Genomic DNA Translation: AAA61762.1
U00096 Genomic DNA Translation: AAC74155.1
AP009048 Genomic DNA Translation: BAA35879.1
PIRiD64850
RefSeqiNP_415589.1, NC_000913.3
WP_000020880.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP0AEM4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP0AEM4, 13 interactors
STRINGi316385.ECDH10B_1142

Proteomic databases

EPDiP0AEM4
PaxDbiP0AEM4
PRIDEiP0AEM4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74155; AAC74155; b1071
BAA35879; BAA35879; BAA35879
GeneIDi946684
KEGGiecj:JW1058
eco:b1071
PATRICifig|1411691.4.peg.1197

Organism-specific databases

EchoBASEiEB2530
EcoGeneiEG12664 flgM

Phylogenomic databases

eggNOGiENOG4105M9M Bacteria
COG2747 LUCA
HOGENOMiHOG000265658
KOiK02398

Enzyme and pathway databases

BioCyciEcoCyc:G369-MONOMER

Miscellaneous databases

PROiPR:P0AEM4

Family and domain databases

InterProiView protein in InterPro
IPR035890 Anti-sigma-28_factor_FlgM_sf
IPR007412 FlgM
IPR031316 FlgM_C
PfamiView protein in Pfam
PF04316 FlgM, 1 hit
SUPFAMiSSF101498 SSF101498, 1 hit
TIGRFAMsiTIGR03824 FlgM_jcvi, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFLGM_ECOLI
AccessioniPrimary (citable) accession number: P0AEM4
Secondary accession number(s): P43532
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: November 7, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again