UniProtKB - P0AEM4 (FLGM_ECOLI)
Protein
Negative regulator of flagellin synthesis
Gene
flgM
Organism
Escherichia coli (strain K12)
Status
Functioni
Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA.
GO - Molecular functioni
- sigma factor antagonist activity Source: EcoCyc
GO - Biological processi
- bacterial-type flagellum organization Source: UniProtKB-KW
- negative regulation of proteolysis Source: EcoCyc
Keywordsi
Molecular function | Repressor |
Biological process | Bacterial flagellum biogenesis, Transcription, Transcription regulation |
Enzyme and pathway databases
BioCyci | EcoCyc:G369-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Negative regulator of flagellin synthesisAlternative name(s): Anti-sigma-28 factor |
Gene namesi | Name:flgM Ordered Locus Names:b1071, JW1058 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000087283 | 1 – 97 | Negative regulator of flagellin synthesisAdd BLAST | 97 |
Proteomic databases
jPOSTi | P0AEM4 |
PaxDbi | P0AEM4 |
PRIDEi | P0AEM4 |
Interactioni
Binary interactionsi
P0AEM4
With | #Exp. | IntAct |
---|---|---|
fliA [P0AEM6] | 4 | EBI-1121952,EBI-549807 |
Protein-protein interaction databases
BioGRIDi | 851026, 1 interactor |
IntActi | P0AEM4, 13 interactors |
STRINGi | 511145.b1071 |
Family & Domainsi
Sequence similaritiesi
Belongs to the FlgM family.Curated
Phylogenomic databases
eggNOGi | COG2747, Bacteria |
HOGENOMi | CLU_149304_2_2_6 |
Family and domain databases
InterProi | View protein in InterPro IPR035890, Anti-sigma-28_factor_FlgM_sf IPR007412, FlgM IPR031316, FlgM_C |
Pfami | View protein in Pfam PF04316, FlgM, 1 hit |
SUPFAMi | SSF101498, SSF101498, 1 hit |
TIGRFAMsi | TIGR03824, FlgM_jcvi, 1 hit |
i Sequence
Sequence statusi: Complete.
P0AEM4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSIDRTSPLK PVSTVQPRET TDAPVTNSRA AKTTASTSTS VTLSDAQAKL
60 70 80 90
MQPGSSDINL ERVEALKLAI RNGELKMDTG KIADALINEA QQDLQSN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U19773 Genomic DNA Translation: AAA61762.1 U00096 Genomic DNA Translation: AAC74155.1 AP009048 Genomic DNA Translation: BAA35879.1 |
PIRi | D64850 |
RefSeqi | NP_415589.1, NC_000913.3 WP_000020880.1, NZ_STEB01000016.1 |
Genome annotation databases
EnsemblBacteriai | AAC74155; AAC74155; b1071 BAA35879; BAA35879; BAA35879 |
GeneIDi | 58461735 946684 |
KEGGi | ecj:JW1058 eco:b1071 |
PATRICi | fig|1411691.4.peg.1197 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U19773 Genomic DNA Translation: AAA61762.1 U00096 Genomic DNA Translation: AAC74155.1 AP009048 Genomic DNA Translation: BAA35879.1 |
PIRi | D64850 |
RefSeqi | NP_415589.1, NC_000913.3 WP_000020880.1, NZ_STEB01000016.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 851026, 1 interactor |
IntActi | P0AEM4, 13 interactors |
STRINGi | 511145.b1071 |
Proteomic databases
jPOSTi | P0AEM4 |
PaxDbi | P0AEM4 |
PRIDEi | P0AEM4 |
Genome annotation databases
EnsemblBacteriai | AAC74155; AAC74155; b1071 BAA35879; BAA35879; BAA35879 |
GeneIDi | 58461735 946684 |
KEGGi | ecj:JW1058 eco:b1071 |
PATRICi | fig|1411691.4.peg.1197 |
Organism-specific databases
EchoBASEi | EB2530 |
Phylogenomic databases
eggNOGi | COG2747, Bacteria |
HOGENOMi | CLU_149304_2_2_6 |
Enzyme and pathway databases
BioCyci | EcoCyc:G369-MONOMER |
Miscellaneous databases
PROi | PR:P0AEM4 |
Family and domain databases
InterProi | View protein in InterPro IPR035890, Anti-sigma-28_factor_FlgM_sf IPR007412, FlgM IPR031316, FlgM_C |
Pfami | View protein in Pfam PF04316, FlgM, 1 hit |
SUPFAMi | SSF101498, SSF101498, 1 hit |
TIGRFAMsi | TIGR03824, FlgM_jcvi, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FLGM_ECOLI | |
Accessioni | P0AEM4Primary (citable) accession number: P0AEM4 Secondary accession number(s): P43532 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | December 20, 2005 | |
Last modified: | April 7, 2021 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families