UniProtKB - P0AEL6 (FEPB_ECOLI)
Protein
Ferrienterobactin-binding periplasmic protein
Gene
fepB
Organism
Escherichia coli (strain K12)
Status
Functioni
Binds ferrienterobactin; part of the binding-protein-dependent transport system for uptake of ferrienterobactin.
GO - Biological processi
- cellular response to DNA damage stimulus Source: EcoliWiki
- enterobactin transport Source: GO_Central
- ferric-enterobactin import into cell Source: EcoCyc
Keywordsi
Biological process | Ion transport, Iron transport, Transport |
Ligand | Iron |
Enzyme and pathway databases
BioCyci | EcoCyc:FEPB-MONOMER MetaCyc:FEPB-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Ferrienterobactin-binding periplasmic protein |
Gene namesi | Name:fepB Ordered Locus Names:b0592, JW0584 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Other locations
Other locations
- outer membrane-bounded periplasmic space Source: EcoCyc
Keywords - Cellular componenti
PeriplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000031821 | 27 – 318 | Ferrienterobactin-binding periplasmic proteinAdd BLAST | 292 |
Proteomic databases
jPOSTi | P0AEL6 |
PaxDbi | P0AEL6 |
PRIDEi | P0AEL6 |
Expressioni
Inductioni
Controlled in part by the amount of available iron. Induced by hydroxyurea (PubMed:20005847).1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260980, 354 interactors |
ComplexPortali | CPX-4404, Ferric-enterobactin ABC transporter complex |
DIPi | DIP-9593N |
IntActi | P0AEL6, 14 interactors |
STRINGi | 511145.b0592 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P0AEL6 |
SMRi | P0AEL6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 48 – 318 | Fe/B12 periplasmic-bindingPROSITE-ProRule annotationAdd BLAST | 271 |
Sequence similaritiesi
Belongs to the bacterial solute-binding protein 8 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | COG4592, Bacteria |
HOGENOMi | CLU_038034_4_0_6 |
InParanoidi | P0AEL6 |
PhylomeDBi | P0AEL6 |
Family and domain databases
InterProi | View protein in InterPro IPR002491, ABC_transptr_periplasmic_BD |
Pfami | View protein in Pfam PF01497, Peripla_BP_2, 1 hit |
PROSITEi | View protein in PROSITE PS50983, FE_B12_PBP, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P0AEL6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLAPLYRNA LLLTGLLLSG IAAVQAADWP RQITDSRGTH TLESQPQRIV
60 70 80 90 100
STSVTLTGSL LAIDAPVIAS GATTPNNRVA DDQGFLRQWS KVAKERKLQR
110 120 130 140 150
LYIGEPSAEA VAAQMPDLIL ISATGGDSAL ALYDQLSTIA PTLIINYDDK
160 170 180 190 200
SWQSLLTQLG EITGHEKQAA ERIAQFDKQL AAAKEQIKLP PQPVTAIVYT
210 220 230 240 250
AAAHSANLWT PESAQGQMLE QLGFTLAKLP AGLNASQSQG KRHDIIQLGG
260 270 280 290 300
ENLAAGLNGE SLFLFAGDQK DADAIYANPL LAHLPAVQNK QVYALGTETF
310
RLDYYSAMQV LDRLKALF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M29730 Genomic DNA Translation: AAA83853.1 U82598 Genomic DNA Translation: AAB40791.1 U00096 Genomic DNA Translation: AAC73693.1 AP009048 Genomic DNA Translation: BAE76347.1 X53274 Genomic DNA Translation: CAA37370.1 |
PIRi | JV0045 |
RefSeqi | NP_415124.1, NC_000913.3 WP_001234311.1, NZ_SSZK01000032.1 |
Genome annotation databases
EnsemblBacteriai | AAC73693; AAC73693; b0592 BAE76347; BAE76347; BAE76347 |
GeneIDi | 57728857 947538 |
KEGGi | ecj:JW0584 eco:b0592 |
PATRICi | fig|1411691.4.peg.1677 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M29730 Genomic DNA Translation: AAA83853.1 U82598 Genomic DNA Translation: AAB40791.1 U00096 Genomic DNA Translation: AAC73693.1 AP009048 Genomic DNA Translation: BAE76347.1 X53274 Genomic DNA Translation: CAA37370.1 |
PIRi | JV0045 |
RefSeqi | NP_415124.1, NC_000913.3 WP_001234311.1, NZ_SSZK01000032.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2M6K | NMR | - | A | 27-318 | [»] | |
2M6L | NMR | - | A | 27-318 | [»] | |
3TLK | X-ray | 1.85 | A/B/C | 1-318 | [»] | |
BMRBi | P0AEL6 | |||||
SMRi | P0AEL6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4260980, 354 interactors |
ComplexPortali | CPX-4404, Ferric-enterobactin ABC transporter complex |
DIPi | DIP-9593N |
IntActi | P0AEL6, 14 interactors |
STRINGi | 511145.b0592 |
Proteomic databases
jPOSTi | P0AEL6 |
PaxDbi | P0AEL6 |
PRIDEi | P0AEL6 |
Genome annotation databases
EnsemblBacteriai | AAC73693; AAC73693; b0592 BAE76347; BAE76347; BAE76347 |
GeneIDi | 57728857 947538 |
KEGGi | ecj:JW0584 eco:b0592 |
PATRICi | fig|1411691.4.peg.1677 |
Organism-specific databases
EchoBASEi | EB0290 |
Phylogenomic databases
eggNOGi | COG4592, Bacteria |
HOGENOMi | CLU_038034_4_0_6 |
InParanoidi | P0AEL6 |
PhylomeDBi | P0AEL6 |
Enzyme and pathway databases
BioCyci | EcoCyc:FEPB-MONOMER MetaCyc:FEPB-MONOMER |
Miscellaneous databases
PROi | PR:P0AEL6 |
Family and domain databases
InterProi | View protein in InterPro IPR002491, ABC_transptr_periplasmic_BD |
Pfami | View protein in Pfam PF01497, Peripla_BP_2, 1 hit |
PROSITEi | View protein in PROSITE PS50983, FE_B12_PBP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FEPB_ECOLI | |
Accessioni | P0AEL6Primary (citable) accession number: P0AEL6 Secondary accession number(s): P14609, Q2MBK9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | December 20, 2005 | |
Last modified: | April 7, 2021 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families