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Protein

Dipeptide transport system permease protein DppB

Gene

dppB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane.

GO - Molecular functioni

  • dipeptide transmembrane transporter activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processPeptide transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:DPPB-MONOMER
MetaCyc:DPPB-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptide transport system permease protein DppB
Gene namesi
Name:dppB
Ordered Locus Names:b3543, JW3512
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12625 dppB

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9PeriplasmicSequence analysis9
Transmembranei10 – 30HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini31 – 102CytoplasmicSequence analysisAdd BLAST72
Transmembranei103 – 123HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini124 – 135PeriplasmicSequence analysisAdd BLAST12
Transmembranei136 – 156HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini157 – 171CytoplasmicSequence analysisAdd BLAST15
Transmembranei172 – 192HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini193 – 200PeriplasmicSequence analysis8
Transmembranei201 – 221HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini222 – 259CytoplasmicSequence analysisAdd BLAST38
Transmembranei260 – 280HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini281 – 309PeriplasmicSequence analysisAdd BLAST29
Transmembranei310 – 330HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini331 – 339CytoplasmicSequence analysis9

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000600051 – 339Dipeptide transport system permease protein DppBAdd BLAST339

Proteomic databases

PaxDbiP0AEF8
PRIDEiP0AEF8

Interactioni

Protein-protein interaction databases

BioGridi4262535, 186 interactors
DIPiDIP-47927N
IntActiP0AEF8, 2 interactors
STRINGi316385.ECDH10B_3722

Structurei

3D structure databases

ProteinModelPortaliP0AEF8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 328ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST233

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CJM Bacteria
COG0601 LUCA
HOGENOMiHOG000170242
InParanoidiP0AEF8
KOiK12369
PhylomeDBiP0AEF8

Family and domain databases

CDDicd06261 TM_PBP2, 1 hit
Gene3Di1.10.3720.10, 1 hit
InterProiView protein in InterPro
IPR000515 MetI-like
IPR035906 MetI-like_sf
PfamiView protein in Pfam
PF00528 BPD_transp_1, 1 hit
SUPFAMiSSF161098 SSF161098, 1 hit
PROSITEiView protein in PROSITE
PS50928 ABC_TM1, 1 hit

Sequencei

Sequence statusi: Complete.

P0AEF8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLQFILRRLG LVIPTFIGIT LLTFAFVHMI PGDPVMIMAG ERGISPERHA
60 70 80 90 100
QLLAELGLDK PMWQQYLHYI WGVMHGDLGI SMKSRIPVWE EFVPRFQATL
110 120 130 140 150
ELGVCAMIFA TAVGIPVGVL AAVKRGSIFD HTAVGLALTG YSMPIFWWGM
160 170 180 190 200
MLIMLVSVHW NLTPVSGRVS DMVFLDDSNP LTGFMLIDTA IWGEDGNFID
210 220 230 240 250
AVAHMILPAI VLGTIPLAVI VRMTRSSMLE VLGEDYIRTA RAKGLTRMRV
260 270 280 290 300
IIVHALRNAM LPVVTVIGLQ VGTLLAGAIL TETIFSWPGL GRWLIDALQR
310 320 330
RDYPVVQGGV LLVATMIILV NLLVDLLYGV VNPRIRHKK
Length:339
Mass (Da):37,497
Last modified:December 6, 2005 - v1
Checksum:iB4B9D2965C365AD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08399 Genomic DNA Translation: AAA23703.1
U00039 Genomic DNA Translation: AAB18521.1
U00096 Genomic DNA Translation: AAC76568.1
AP009048 Genomic DNA Translation: BAE77751.1
PIRiS47765
RefSeqiNP_418000.1, NC_000913.3
WP_000938855.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76568; AAC76568; b3543
BAE77751; BAE77751; BAE77751
GeneIDi948063
KEGGiecj:JW3512
eco:b3543
PATRICifig|1411691.4.peg.3172

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08399 Genomic DNA Translation: AAA23703.1
U00039 Genomic DNA Translation: AAB18521.1
U00096 Genomic DNA Translation: AAC76568.1
AP009048 Genomic DNA Translation: BAE77751.1
PIRiS47765
RefSeqiNP_418000.1, NC_000913.3
WP_000938855.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP0AEF8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262535, 186 interactors
DIPiDIP-47927N
IntActiP0AEF8, 2 interactors
STRINGi316385.ECDH10B_3722

Proteomic databases

PaxDbiP0AEF8
PRIDEiP0AEF8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76568; AAC76568; b3543
BAE77751; BAE77751; BAE77751
GeneIDi948063
KEGGiecj:JW3512
eco:b3543
PATRICifig|1411691.4.peg.3172

Organism-specific databases

EchoBASEiEB2509
EcoGeneiEG12625 dppB

Phylogenomic databases

eggNOGiENOG4105CJM Bacteria
COG0601 LUCA
HOGENOMiHOG000170242
InParanoidiP0AEF8
KOiK12369
PhylomeDBiP0AEF8

Enzyme and pathway databases

BioCyciEcoCyc:DPPB-MONOMER
MetaCyc:DPPB-MONOMER

Miscellaneous databases

PROiPR:P0AEF8

Family and domain databases

CDDicd06261 TM_PBP2, 1 hit
Gene3Di1.10.3720.10, 1 hit
InterProiView protein in InterPro
IPR000515 MetI-like
IPR035906 MetI-like_sf
PfamiView protein in Pfam
PF00528 BPD_transp_1, 1 hit
SUPFAMiSSF161098 SSF161098, 1 hit
PROSITEiView protein in PROSITE
PS50928 ABC_TM1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDPPB_ECOLI
AccessioniPrimary (citable) accession number: P0AEF8
Secondary accession number(s): P37316, Q2M7K5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: November 7, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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Main funding by: National Institutes of Health

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