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Protein

DNA replication protein DnaC

Gene

dnaC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is required for chromosomal replication. It forms, in concert with DnaB protein and other prepriming proteins DnaT, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei69Probably involved in the interaction with the DnaB protein1

GO - Molecular functioni

GO - Biological processi

  • DNA replication Source: GO_Central
  • DNA replication, synthesis of RNA primer Source: UniProtKB-KW
  • DNA strand elongation involved in DNA replication Source: EcoCyc

Keywordsi

Biological processDNA replication
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG10237-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication protein DnaC
Gene namesi
Name:dnaC
Synonyms:dnaD
Ordered Locus Names:b4361, JW4325
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10237 dnaC

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Primosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000799541 – 245DNA replication protein DnaCAdd BLAST245

Proteomic databases

PaxDbiP0AEF0
PRIDEiP0AEF0

Expressioni

Inductioni

Induced by hydroxyurea.1 Publication

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
dnaBP0ACB012EBI-549012,EBI-548978

Protein-protein interaction databases

BioGridi4262755, 8 interactors
ComplexPortaliCPX-1934 DnaB-DnaC complex
CPX-1950 DnaA-DnaB-DnaC complex
CPX-1951 DnaB-DnaC-DnaT-PriA-PriB complex
CPX-1952 DnaB-DnaC-DnaT-PriA-PriC complex
CPX-1953 DnaB-DnaC-Rep-PriC complex
DIPiDIP-9457N
IntActiP0AEF0, 13 interactors
STRINGi316385.ECDH10B_4517

Structurei

3D structure databases

ProteinModelPortaliP0AEF0
SMRiP0AEF0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaC family.Curated

Phylogenomic databases

eggNOGiENOG4106CVF Bacteria
COG1484 LUCA
HOGENOMiHOG000120230
InParanoidiP0AEF0
KOiK02315
PhylomeDBiP0AEF0

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR028350 DNAC/ATP-binding
IPR002611 IstB_ATP-bd
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01695 IstB_IS21, 1 hit
PIRSFiPIRSF003073 DNAC_TnpB_IstB, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

P0AEF0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKNVGDLMQR LQKMMPAHIK PAFKTGEELL AWQKEQGAIR SAALERENRA
60 70 80 90 100
MKMQRTFNRS GIRPLHQNCS FENYRVECEG QMNALSKARQ YVEEFDGNIA
110 120 130 140 150
SFIFSGKPGT GKNHLAAAIC NELLLRGKSV LIITVADIMS AMKDTFRNSG
160 170 180 190 200
TSEEQLLNDL SNVDLLVIDE IGVQTESKYE KVIINQIVDR RSSSKRPTGM
210 220 230 240
LTNSNMEEMT KLLGERVMDR MRLGNSLWVI FNWDSYRSRV TGKEY
Length:245
Mass (Da):27,935
Last modified:December 6, 2005 - v1
Checksum:iC5CC7232E21F11F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04030 Genomic DNA Translation: AAA23700.1
U14003 Genomic DNA Translation: AAA97260.1
U00096 Genomic DNA Translation: AAC77317.1
AP009048 Genomic DNA Translation: BAE78351.1
PIRiA28484 XMECNC
RefSeqiNP_418781.1, NC_000913.3
WP_000799911.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77317; AAC77317; b4361
BAE78351; BAE78351; BAE78351
GeneIDi948864
KEGGiecj:JW4325
eco:b4361
PATRICifig|1411691.4.peg.2325

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04030 Genomic DNA Translation: AAA23700.1
U14003 Genomic DNA Translation: AAA97260.1
U00096 Genomic DNA Translation: AAC77317.1
AP009048 Genomic DNA Translation: BAE78351.1
PIRiA28484 XMECNC
RefSeqiNP_418781.1, NC_000913.3
WP_000799911.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP0AEF0
SMRiP0AEF0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262755, 8 interactors
ComplexPortaliCPX-1934 DnaB-DnaC complex
CPX-1950 DnaA-DnaB-DnaC complex
CPX-1951 DnaB-DnaC-DnaT-PriA-PriB complex
CPX-1952 DnaB-DnaC-DnaT-PriA-PriC complex
CPX-1953 DnaB-DnaC-Rep-PriC complex
DIPiDIP-9457N
IntActiP0AEF0, 13 interactors
STRINGi316385.ECDH10B_4517

Proteomic databases

PaxDbiP0AEF0
PRIDEiP0AEF0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77317; AAC77317; b4361
BAE78351; BAE78351; BAE78351
GeneIDi948864
KEGGiecj:JW4325
eco:b4361
PATRICifig|1411691.4.peg.2325

Organism-specific databases

EchoBASEiEB0233
EcoGeneiEG10237 dnaC

Phylogenomic databases

eggNOGiENOG4106CVF Bacteria
COG1484 LUCA
HOGENOMiHOG000120230
InParanoidiP0AEF0
KOiK02315
PhylomeDBiP0AEF0

Enzyme and pathway databases

BioCyciEcoCyc:EG10237-MONOMER

Miscellaneous databases

PROiPR:P0AEF0

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR028350 DNAC/ATP-binding
IPR002611 IstB_ATP-bd
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01695 IstB_IS21, 1 hit
PIRSFiPIRSF003073 DNAC_TnpB_IstB, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDNAC_ECOLI
AccessioniPrimary (citable) accession number: P0AEF0
Secondary accession number(s): P07905, Q2M5V5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: December 6, 2005
Last modified: November 7, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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Main funding by: National Institutes of Health

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