UniProtKB - P0AED5 (UVRY_ECOLI)
Protein
Response regulator UvrY
Gene
uvrY
Organism
Escherichia coli (strain K12)
Status
Functioni
Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the effects of CsrA on csrB RNA by BarA-dependent and BarA-independent mechanisms.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 167 – 186 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 20 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- phosphorelay response regulator activity Source: EcoCyc
GO - Biological processi
- phosphorelay signal transduction system Source: EcoCyc
- regulation of transcription, DNA-templated Source: InterPro
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation, Two-component regulatory system |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11140-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Response regulator UvrY |
Gene namesi | Name:uvrY Synonyms:yecB Ordered Locus Names:b1914, JW1899 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm Curated
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000081292 | 1 – 218 | Response regulator UvrYAdd BLAST | 218 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 54 | 4-aspartylphosphatePROSITE-ProRule annotation | 1 |
Post-translational modificationi
Phosphorylated and activated by BarA.
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | P0AED5 |
PaxDbi | P0AED5 |
PRIDEi | P0AED5 |
Expressioni
Inductioni
Expression is regulated by SidA.
Interactioni
Protein-protein interaction databases
BioGRIDi | 4261107, 103 interactors |
DIPi | DIP-35922N |
IntActi | P0AED5, 37 interactors |
STRINGi | 511145.b1914 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 119 | Response regulatoryPROSITE-ProRule annotationAdd BLAST | 117 | |
Domaini | 143 – 208 | HTH luxR-typePROSITE-ProRule annotationAdd BLAST | 66 |
Phylogenomic databases
eggNOGi | COG2197, Bacteria |
HOGENOMi | CLU_000445_90_1_6 |
InParanoidi | P0AED5 |
PhylomeDBi | P0AED5 |
Family and domain databases
CDDi | cd06170, LuxR_C_like, 1 hit cd00156, REC, 1 hit |
InterProi | View protein in InterPro IPR011006, CheY-like_superfamily IPR016032, Sig_transdc_resp-reg_C-effctor IPR001789, Sig_transdc_resp-reg_receiver IPR000792, Tscrpt_reg_LuxR_C |
Pfami | View protein in Pfam PF00196, GerE, 1 hit PF00072, Response_reg, 1 hit |
PRINTSi | PR00038, HTHLUXR |
SMARTi | View protein in SMART SM00421, HTH_LUXR, 1 hit SM00448, REC, 1 hit |
SUPFAMi | SSF46894, SSF46894, 1 hit SSF52172, SSF52172, 1 hit |
PROSITEi | View protein in PROSITE PS00622, HTH_LUXR_1, 1 hit PS50043, HTH_LUXR_2, 1 hit PS50110, RESPONSE_REGULATORY, 1 hit |
i Sequence
Sequence statusi: Complete.
P0AED5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MINVLLVDDH ELVRAGIRRI LEDIKGIKVV GEASCGEDAV KWCRTNAVDV
60 70 80 90 100
VLMDMSMPGI GGLEATRKIA RSTADVKIIM LTVHTENPLP AKVMQAGAAG
110 120 130 140 150
YLSKGAAPQE VVSAIRSVYS GQRYIASDIA QQMALSQIEP EKTESPFASL
160 170 180 190 200
SERELQIMLM ITKGQKVNEI SEQLNLSPKT VNSYRYRMFS KLNIHGDVEL
210
THLAIRHGLC NAETLSSQ
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 8 – 9 | DD → MT in CAA27328 (PubMed:3515318).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M24615 Genomic DNA Translation: AAA24755.1 U00096 Genomic DNA Translation: AAC74981.1 AP009048 Genomic DNA Translation: BAA15734.1 X05398 Genomic DNA Translation: CAA28982.1 X03691 Genomic DNA Translation: CAA27328.1 |
PIRi | A26750, QQEC24 |
RefSeqi | NP_416424.1, NC_000913.3 WP_000611335.1, NZ_STEB01000026.1 |
Genome annotation databases
EnsemblBacteriai | AAC74981; AAC74981; b1914 BAA15734; BAA15734; BAA15734 |
GeneIDi | 58461782 946424 |
KEGGi | ecj:JW1899 eco:b1914 |
PATRICi | fig|1411691.4.peg.336 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M24615 Genomic DNA Translation: AAA24755.1 U00096 Genomic DNA Translation: AAC74981.1 AP009048 Genomic DNA Translation: BAA15734.1 X05398 Genomic DNA Translation: CAA28982.1 X03691 Genomic DNA Translation: CAA27328.1 |
PIRi | A26750, QQEC24 |
RefSeqi | NP_416424.1, NC_000913.3 WP_000611335.1, NZ_STEB01000026.1 |
3D structure databases
SMRi | P0AED5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4261107, 103 interactors |
DIPi | DIP-35922N |
IntActi | P0AED5, 37 interactors |
STRINGi | 511145.b1914 |
Proteomic databases
jPOSTi | P0AED5 |
PaxDbi | P0AED5 |
PRIDEi | P0AED5 |
Genome annotation databases
EnsemblBacteriai | AAC74981; AAC74981; b1914 BAA15734; BAA15734; BAA15734 |
GeneIDi | 58461782 946424 |
KEGGi | ecj:JW1899 eco:b1914 |
PATRICi | fig|1411691.4.peg.336 |
Organism-specific databases
EchoBASEi | EB1130 |
Phylogenomic databases
eggNOGi | COG2197, Bacteria |
HOGENOMi | CLU_000445_90_1_6 |
InParanoidi | P0AED5 |
PhylomeDBi | P0AED5 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11140-MONOMER |
Miscellaneous databases
PROi | PR:P0AED5 |
Family and domain databases
CDDi | cd06170, LuxR_C_like, 1 hit cd00156, REC, 1 hit |
InterProi | View protein in InterPro IPR011006, CheY-like_superfamily IPR016032, Sig_transdc_resp-reg_C-effctor IPR001789, Sig_transdc_resp-reg_receiver IPR000792, Tscrpt_reg_LuxR_C |
Pfami | View protein in Pfam PF00196, GerE, 1 hit PF00072, Response_reg, 1 hit |
PRINTSi | PR00038, HTHLUXR |
SMARTi | View protein in SMART SM00421, HTH_LUXR, 1 hit SM00448, REC, 1 hit |
SUPFAMi | SSF46894, SSF46894, 1 hit SSF52172, SSF52172, 1 hit |
PROSITEi | View protein in PROSITE PS00622, HTH_LUXR_1, 1 hit PS50043, HTH_LUXR_2, 1 hit PS50110, RESPONSE_REGULATORY, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UVRY_ECOLI | |
Accessioni | P0AED5Primary (citable) accession number: P0AED5 Secondary accession number(s): P07027 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1988 |
Last sequence update: | December 6, 2005 | |
Last modified: | February 10, 2021 | |
This is version 116 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |