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Protein

Universal stress protein A

Gene

uspA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for resistance to DNA-damaging agents.

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

Enzyme and pathway databases

BioCyciEcoCyc:EG11390-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Universal stress protein A
Gene namesi
Name:uspA
Ordered Locus Names:b3495, JW3462
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11390 uspA

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved4 Publications
ChainiPRO_00001473962 – 144Universal stress protein AAdd BLAST143

Post-translational modificationi

Phosphorylated on serine or threonine in response to stasis.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP0AED0
PaxDbiP0AED0
PRIDEiP0AED0

2D gel databases

SWISS-2DPAGEiP0AED0

Expressioni

Inductioni

During growth inhibition caused by the exhaustion of any of a variety of nutrients (carbon, nitrogen, phosphate, sulfate, required amino acid) or by the presence of a variety of toxic agents. Positively regulated by guanosine 3',5'-bisphosphate (ppGpp) and by a RecA/FtsK-dependent regulatory pathway. Negatively regulated by FadR. Also regulated by CspC and CspE.

Interactioni

Subunit structurei

Homodimer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-552843,EBI-552843

GO - Molecular functioni

Protein-protein interaction databases

BioGridi4262517, 6 interactors
DIPiDIP-36230N
IntActiP0AED0, 9 interactors
STRINGi316385.ECDH10B_3671

Structurei

3D structure databases

ProteinModelPortaliP0AED0
SMRiP0AED0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the universal stress protein A family.Curated

Phylogenomic databases

eggNOGiCOG0589 LUCA
HOGENOMiHOG000238899
InParanoidiP0AED0
KOiK06149
OMAiQVMNSIT
PhylomeDBiP0AED0

Family and domain databases

Gene3Di3.40.50.620, 1 hit
InterProiView protein in InterPro
IPR014729 Rossmann-like_a/b/a_fold
IPR006015 Universal_stress_UspA
IPR006016 UspA
PfamiView protein in Pfam
PF00582 Usp, 1 hit
PIRSFiPIRSF006276 UspA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0AED0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAYKHILIAV DLSPESKVLV EKAVSMARPY NAKVSLIHVD VNYSDLYTGL
60 70 80 90 100
IDVNLGDMQK RISEETHHAL TELSTNAGYP ITETLSGSGD LGQVLVDAIK
110 120 130 140
KYDMDLVVCG HHQDFWSKLM SSARQLINTV HVDMLIVPLR DEEE
Length:144
Mass (Da):16,066
Last modified:January 23, 2007 - v2
Checksum:iEE3BF2141E44D826
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti140R → A in CAA47884 (PubMed:1453957).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67639 Genomic DNA Translation: CAA47884.1
U00039 Genomic DNA Translation: AAB18471.1
U00096 Genomic DNA Translation: AAC76520.1
AP009048 Genomic DNA Translation: BAE77799.1
PIRiS47715
RefSeqiNP_417952.1, NC_000913.3
WP_000323571.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76520; AAC76520; b3495
BAE77799; BAE77799; BAE77799
GeneIDi948007
KEGGiecj:JW3462
eco:b3495
PATRICifig|511145.12.peg.3597

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67639 Genomic DNA Translation: CAA47884.1
U00039 Genomic DNA Translation: AAB18471.1
U00096 Genomic DNA Translation: AAC76520.1
AP009048 Genomic DNA Translation: BAE77799.1
PIRiS47715
RefSeqiNP_417952.1, NC_000913.3
WP_000323571.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP0AED0
SMRiP0AED0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262517, 6 interactors
DIPiDIP-36230N
IntActiP0AED0, 9 interactors
STRINGi316385.ECDH10B_3671

2D gel databases

SWISS-2DPAGEiP0AED0

Proteomic databases

EPDiP0AED0
PaxDbiP0AED0
PRIDEiP0AED0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76520; AAC76520; b3495
BAE77799; BAE77799; BAE77799
GeneIDi948007
KEGGiecj:JW3462
eco:b3495
PATRICifig|511145.12.peg.3597

Organism-specific databases

EchoBASEiEB1363
EcoGeneiEG11390 uspA

Phylogenomic databases

eggNOGiCOG0589 LUCA
HOGENOMiHOG000238899
InParanoidiP0AED0
KOiK06149
OMAiQVMNSIT
PhylomeDBiP0AED0

Enzyme and pathway databases

BioCyciEcoCyc:EG11390-MONOMER

Miscellaneous databases

PROiPR:P0AED0

Family and domain databases

Gene3Di3.40.50.620, 1 hit
InterProiView protein in InterPro
IPR014729 Rossmann-like_a/b/a_fold
IPR006015 Universal_stress_UspA
IPR006016 UspA
PfamiView protein in Pfam
PF00582 Usp, 1 hit
PIRSFiPIRSF006276 UspA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUSPA_ECOLI
AccessioniPrimary (citable) accession number: P0AED0
Secondary accession number(s): P28242, Q2M7F7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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Main funding by: National Institutes of Health

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