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UniProtKB - P0AEC0 (YOAE_ECOLI)

Entry version 109 (07 Oct 2020)
Sequence version 1 (06 Dec 2005)
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Protein

UPF0053 inner membrane protein YoaE

Gene

yoaE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:G6997-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UPF0053 inner membrane protein YoaE
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:yoaE
Ordered Locus Names:b1816, JW1805
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 48PeriplasmicSequence analysisAdd BLAST14
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Topological domaini70 – 78CytoplasmicSequence analysis9
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Topological domaini100 – 124PeriplasmicSequence analysisAdd BLAST25
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Topological domaini146 – 149CytoplasmicSequence analysis4
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Topological domaini171 – 184PeriplasmicSequence analysisAdd BLAST14
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Topological domaini206CytoplasmicSequence analysis1
Transmembranei207 – 227HelicalSequence analysisAdd BLAST21
Topological domaini228 – 354PeriplasmicSequence analysisAdd BLAST127
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Topological domaini376 – 518CytoplasmicSequence analysisAdd BLAST143

GO - Cellular componenti

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000883591 – 518UPF0053 inner membrane protein YoaEAdd BLAST518

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P0AEC0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P0AEC0

PRoteomics IDEntifications database

More...PRIDEi		P0AEC0

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4260347, 14 interactors
850692, 1 interactor

Protein interaction database and analysis system

More...IntActi		P0AEC0, 1 interactor

STRING: functional protein association networks

More...STRINGi		511145.b1816

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini304 – 363CBS 1PROSITE-ProRule annotationAdd BLAST60
Domaini367 – 427CBS 2PROSITE-ProRule annotationAdd BLAST61

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UPF0053 family.Curated

Keywords - Domaini

CBS domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG1253, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_015237_0_0_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P0AEC0

Database for complete collections of gene phylogenies

More...PhylomeDBi		P0AEC0

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.465.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000644, CBS_dom
IPR036318, FAD-bd_PCMH-like_sf
IPR016169, FAD-bd_PCMH_sub2
IPR005496, Integral_membrane_TerC
IPR005170, Transptr-assoc_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03471, CorC_HlyC, 1 hit
PF03741, TerC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01091, CorC_HlyC, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56176, SSF56176, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51371, CBS, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0AEC0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEFLMDPSIW AGLLTLVVLE IVLGIDNLVF IAILADKLPP KQRDKARLLG 
        60         70         80         90        100
LSLALIMRLG LLSLISWMVT LTKPLFTVMD FSFSGRDLIM LFGGIFLLFK 
       110        120        130        140        150
ATTELHERLE NRDHDSGHGK GYASFWVVVT QIVILDAVFS LDAVITAVGM 
       160        170        180        190        200
VNHLPVMMAA VVIAMAVMLL ASKPLTRFVN QHPTVVVLCL SFLLMIGLSL 
       210        220        230        240        250
VAEGFGFHIP KGYLYAAIGF SIIIEVFNQI ARRNFIRHQS TLPLRARTAD 
       260        270        280        290        300
AILRLMGGKR QANVQHDADN PMPMPIPEGA FAEEERYMIN GVLTLASRSL 
       310        320        330        340        350
RGIMTPRGEI SWVDANLGVD EIREQLLSSP HSLFPVCRGE LDEIIGIVRA 
       360        370        380        390        400
KELLVALEEG VDVAAIASAS PAIIVPETLD PINLLGVLRR ARGSFVIVTN 
       410        420        430        440        450
EFGVVQGLVT PLDVLEAIAG EFPDADETPE IITDGDGWLV KGGTDLHALQ 
       460        470        480        490        500
QALDVEHLAD DDDIATVAGL VISANGHIPR VGDVIDVGPL HITIIEANDY 
       510 
RVDLVRIVKE QPAHDEDE
Length:518
Mass (Da):56,528
Last modified:December 6, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i90DF7C9A092F1ECC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74886.1
AP009048 Genomic DNA Translation: BAA15623.1

Protein sequence database of the Protein Information Resource

More...PIRi		H64942

NCBI Reference Sequences

More...RefSeqi		NP_416330.1, NC_000913.3
WP_000394983.1, NZ_STEB01000009.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC74886; AAC74886; b1816
BAA15623; BAA15623; BAA15623

Database of genes from NCBI RefSeq genomes

More...GeneIDi		49584434
946335

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW1805
eco:b1816

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|511145.12.peg.1893

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74886.1
AP009048 Genomic DNA Translation: BAA15623.1
PIRiH64942
RefSeqiNP_416330.1, NC_000913.3
WP_000394983.1, NZ_STEB01000009.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4260347, 14 interactors
850692, 1 interactor
IntActiP0AEC0, 1 interactor
STRINGi511145.b1816

Proteomic databases

jPOSTiP0AEC0
PaxDbiP0AEC0
PRIDEiP0AEC0

Genome annotation databases

EnsemblBacteriaiAAC74886; AAC74886; b1816
BAA15623; BAA15623; BAA15623
GeneIDi49584434
946335
KEGGiecj:JW1805
eco:b1816
PATRICifig|511145.12.peg.1893

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB3290

Phylogenomic databases

eggNOGiCOG1253, Bacteria
HOGENOMiCLU_015237_0_0_6
InParanoidiP0AEC0
PhylomeDBiP0AEC0

Enzyme and pathway databases

BioCyciEcoCyc:G6997-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P0AEC0

Family and domain databases

Gene3Di3.30.465.10, 1 hit
InterProiView protein in InterPro
IPR000644, CBS_dom
IPR036318, FAD-bd_PCMH-like_sf
IPR016169, FAD-bd_PCMH_sub2
IPR005496, Integral_membrane_TerC
IPR005170, Transptr-assoc_dom
PfamiView protein in Pfam
PF03471, CorC_HlyC, 1 hit
PF03741, TerC, 1 hit
SMARTiView protein in SMART
SM01091, CorC_HlyC, 1 hit
SUPFAMiSSF56176, SSF56176, 1 hit
PROSITEiView protein in PROSITE
PS51371, CBS, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYOAE_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0AEC0
Secondary accession number(s): P76262
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: October 7, 2020
This is version 109 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  2. SIMILARITY comments
    Index of protein domains and families
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