UniProtKB - P0AEB0 (CYSW_ECOLI)
Protein
Sulfate transport system permease protein CysW
Gene
cysW
Organism
Escherichia coli (strain K12)
Status
Functioni
Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
GO - Molecular functioni
- ATPase-coupled sulfate transmembrane transporter activity Source: InterPro
Keywordsi
Biological process | Sulfate transport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:CYSW-MONOMER MetaCyc:CYSW-MONOMER |
Protein family/group databases
TCDBi | 3.A.1.6.1, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Sulfate transport system permease protein CysW |
Gene namesi | Name:cysW Ordered Locus Names:b2423, JW2416 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 22 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 23 – 43 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 44 – 69 | PeriplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 70 – 90 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 91 – 104 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 105 – 125 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 126 – 141 | PeriplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 142 – 162 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 163 – 200 | CytoplasmicSequence analysisAdd BLAST | 38 | |
Transmembranei | 201 – 221 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 222 – 247 | PeriplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 248 – 268 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 269 – 291 | CytoplasmicSequence analysisAdd BLAST | 23 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000059997 | 1 – 291 | Sulfate transport system permease protein CysWAdd BLAST | 291 |
Proteomic databases
PaxDbi | P0AEB0 |
PRIDEi | P0AEB0 |
Interactioni
Subunit structurei
The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).
CuratedProtein-protein interaction databases
BioGRIDi | 4260746, 9 interactors |
ComplexPortali | CPX-4385, Sulfate/thiosulfate ABC transporter complex, cypP variant CPX-4386, Sulfate/thiosulfate ABC transporter complex, sbp variant |
DIPi | DIP-9388N |
IntActi | P0AEB0, 2 interactors |
STRINGi | 511145.b2423 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 66 – 270 | ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST | 205 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG4208, Bacteria |
HOGENOMi | CLU_016047_14_0_6 |
InParanoidi | P0AEB0 |
PhylomeDBi | P0AEB0 |
Family and domain databases
CDDi | cd06261, TM_PBP2, 1 hit |
Gene3Di | 1.10.3720.10, 1 hit |
InterProi | View protein in InterPro IPR011866, CysW_permease IPR000515, MetI-like IPR035906, MetI-like_sf IPR005667, Sulph_transpt2 |
PANTHERi | PTHR30406, PTHR30406, 1 hit PTHR30406:SF9, PTHR30406:SF9, 1 hit |
Pfami | View protein in Pfam PF00528, BPD_transp_1, 1 hit |
SUPFAMi | SSF161098, SSF161098, 1 hit |
TIGRFAMsi | TIGR00969, 3a0106s02, 1 hit TIGR02140, permease_CysW, 1 hit |
PROSITEi | View protein in PROSITE PS50928, ABC_TM1, 1 hit |
i Sequence
Sequence statusi: Complete.
P0AEB0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEVTQLKRY DARPINWGKW FLIGIGMLVS AFILLVPMIY IFVQAFSKGL
60 70 80 90 100
MPVLQNLADP DMLHAIWLTV MIALIAVPVN LVFGILLAWL VTRFNFPGRQ
110 120 130 140 150
LLLTLLDIPF AVSPVVAGLV YLLFYGSNGP LGGWLDEHNL QIMFSWPGMV
160 170 180 190 200
LVTIFVTCPF VVRELVPVML SQGSQEDEAA ILLGASGWQM FRRVTLPNIR
210 220 230 240 250
WALLYGVVLT NARAIGEFGA VSVVSGSIRG ETLSLPLQIE LLEQDYNTVG
260 270 280 290
SFTAAALLTL MAIITLFLKS MLQWRLENQE KRAQQEEHHE H
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M32101 Genomic DNA Translation: AAA23638.1 U00096 Genomic DNA Translation: AAC75476.2 AP009048 Genomic DNA Translation: BAA16297.1 |
PIRi | F65016, QRECSW |
RefSeqi | WP_000852686.1, NZ_STEB01000039.1 YP_026168.2, NC_000913.3 |
Genome annotation databases
EnsemblBacteriai | AAC75476; AAC75476; b2423 BAA16297; BAA16297; BAA16297 |
GeneIDi | 2847743 49583718 |
KEGGi | ecj:JW2416 eco:b2423 |
PATRICi | fig|1411691.4.peg.4308 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M32101 Genomic DNA Translation: AAA23638.1 U00096 Genomic DNA Translation: AAC75476.2 AP009048 Genomic DNA Translation: BAA16297.1 |
PIRi | F65016, QRECSW |
RefSeqi | WP_000852686.1, NZ_STEB01000039.1 YP_026168.2, NC_000913.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4260746, 9 interactors |
ComplexPortali | CPX-4385, Sulfate/thiosulfate ABC transporter complex, cypP variant CPX-4386, Sulfate/thiosulfate ABC transporter complex, sbp variant |
DIPi | DIP-9388N |
IntActi | P0AEB0, 2 interactors |
STRINGi | 511145.b2423 |
Protein family/group databases
TCDBi | 3.A.1.6.1, the atp-binding cassette (abc) superfamily |
Proteomic databases
PaxDbi | P0AEB0 |
PRIDEi | P0AEB0 |
Genome annotation databases
EnsemblBacteriai | AAC75476; AAC75476; b2423 BAA16297; BAA16297; BAA16297 |
GeneIDi | 2847743 49583718 |
KEGGi | ecj:JW2416 eco:b2423 |
PATRICi | fig|1411691.4.peg.4308 |
Organism-specific databases
EchoBASEi | EB0195 |
Phylogenomic databases
eggNOGi | COG4208, Bacteria |
HOGENOMi | CLU_016047_14_0_6 |
InParanoidi | P0AEB0 |
PhylomeDBi | P0AEB0 |
Enzyme and pathway databases
BioCyci | EcoCyc:CYSW-MONOMER MetaCyc:CYSW-MONOMER |
Miscellaneous databases
PROi | PR:P0AEB0 |
Family and domain databases
CDDi | cd06261, TM_PBP2, 1 hit |
Gene3Di | 1.10.3720.10, 1 hit |
InterProi | View protein in InterPro IPR011866, CysW_permease IPR000515, MetI-like IPR035906, MetI-like_sf IPR005667, Sulph_transpt2 |
PANTHERi | PTHR30406, PTHR30406, 1 hit PTHR30406:SF9, PTHR30406:SF9, 1 hit |
Pfami | View protein in Pfam PF00528, BPD_transp_1, 1 hit |
SUPFAMi | SSF161098, SSF161098, 1 hit |
TIGRFAMsi | TIGR00969, 3a0106s02, 1 hit TIGR02140, permease_CysW, 1 hit |
PROSITEi | View protein in PROSITE PS50928, ABC_TM1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CYSW_ECOLI | |
Accessioni | P0AEB0Primary (citable) accession number: P0AEB0 Secondary accession number(s): P16702, P76534 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2005 |
Last sequence update: | December 6, 2005 | |
Last modified: | December 2, 2020 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families