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Entry version 110 (13 Nov 2019)
Sequence version 1 (06 Dec 2005)
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Protein

Protoheme IX farnesyltransferase

Gene

cyoE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.2 Publications

Miscellaneous

Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: heme O biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes heme O from protoheme.
Proteins known to be involved in this subpathway in this organism are:
  1. Protoheme IX farnesyltransferase (cyoE), Protoheme IX farnesyltransferase (cyoE), Protoheme IX farnesyltransferase (cyoE), Protoheme IX farnesyltransferase (cyoE)
This subpathway is part of the pathway heme O biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes heme O from protoheme, the pathway heme O biosynthesis and in Porphyrin-containing compound metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protoheme IX farnesyltransferase activity Source: EcoliWiki

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processHeme biosynthesis

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:HEMEOSYN-MONOMER
ECOL316407:JW0418-MONOMER
MetaCyc:HEMEOSYN-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.5.1.B36 2026

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00834;UER00712

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protoheme IX farnesyltransferase (EC:2.5.1.141)
Alternative name(s):
Heme B farnesyltransferase
Heme O synthase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cyoE
Ordered Locus Names:b0428, JW0418
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 9CytoplasmicCurated9
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 28HelicalCuratedAdd BLAST19
Topological domaini29 – 37PeriplasmicCurated9
Transmembranei38 – 56HelicalCuratedAdd BLAST19
Topological domaini57 – 78CytoplasmicCuratedAdd BLAST22
Transmembranei79 – 97HelicalCuratedAdd BLAST19
Topological domaini98 – 107PeriplasmicCurated10
Transmembranei108 – 126HelicalCuratedAdd BLAST19
Topological domaini127 – 197CytoplasmicCuratedAdd BLAST71
Transmembranei198 – 216HelicalCuratedAdd BLAST19
Topological domaini217 – 228PeriplasmicCuratedAdd BLAST12
Transmembranei229 – 247HelicalCuratedAdd BLAST19
Topological domaini248 – 268CytoplasmicCuratedAdd BLAST21
Transmembranei269 – 287HelicalCuratedAdd BLAST19
Topological domaini288 – 296PeriplasmicCurated9

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001628951 – 296Protoheme IX farnesyltransferaseAdd BLAST296

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0AEA5

PRoteomics IDEntifications database

More...
PRIDEi
P0AEA5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4259839, 24 interactors

Database of interacting proteins

More...
DIPi
DIP-47946N

STRING: functional protein association networks

More...
STRINGi
511145.b0428

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105F1R Bacteria
COG0109 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000237290

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0AEA5

KEGG Orthology (KO)

More...
KOi
K02257

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0AEA5

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13957 PT_UbiA_Cox10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00154 CyoE_CtaB, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006369 Protohaem_IX_farnesylTrfase
IPR000537 UbiA_prenyltransferase
IPR030470 UbiA_prenylTrfase_CS

The PANTHER Classification System

More...
PANTHERi
PTHR43448 PTHR43448, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01040 UbiA, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01473 cyoE_ctaB, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00943 UBIA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0AEA5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMFKQYLQVT KPGIIFGNLI SVIGGFLLAS KGSIDYPLFI YTLVGVSLVV
60 70 80 90 100
ASGCVFNNYI DRDIDRKMER TKNRVLVKGL ISPAVSLVYA TLLGIAGFML
110 120 130 140 150
LWFGANPLAC WLGVMGFVVY VGVYSLYMKR HSVYGTLIGS LSGAAPPVIG
160 170 180 190 200
YCAVTGEFDS GAAILLAIFS LWQMPHSYAI AIFRFKDYQA ANIPVLPVVK
210 220 230 240 250
GISVAKNHIT LYIIAFAVAT LMLSLGGYAG YKYLVVAAAV SVWWLGMALR
260 270 280 290
GYKVADDRIW ARKLFGFSII AITALSVMMS VDFMVPDSHT LLAAVW
Length:296
Mass (Da):32,248
Last modified:December 6, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD3AFC612ECFB450E
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB40184 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J05492 Genomic DNA Translation: AAA23635.1
U82664 Genomic DNA Translation: AAB40184.1 Different initiation.
U00096 Genomic DNA Translation: AAC73531.1
AP009048 Genomic DNA Translation: BAE76208.1

Protein sequence database of the Protein Information Resource

More...
PIRi
E42226

NCBI Reference Sequences

More...
RefSeqi
NP_414962.1, NC_000913.3
WP_000971336.1, NZ_SSZK01000009.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC73531; AAC73531; b0428
BAE76208; BAE76208; BAE76208

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
945073

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW0418
eco:b0428

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.1849

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05492 Genomic DNA Translation: AAA23635.1
U82664 Genomic DNA Translation: AAB40184.1 Different initiation.
U00096 Genomic DNA Translation: AAC73531.1
AP009048 Genomic DNA Translation: BAE76208.1
PIRiE42226
RefSeqiNP_414962.1, NC_000913.3
WP_000971336.1, NZ_SSZK01000009.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi4259839, 24 interactors
DIPiDIP-47946N
STRINGi511145.b0428

Proteomic databases

PaxDbiP0AEA5
PRIDEiP0AEA5

Genome annotation databases

EnsemblBacteriaiAAC73531; AAC73531; b0428
BAE76208; BAE76208; BAE76208
GeneIDi945073
KEGGiecj:JW0418
eco:b0428
PATRICifig|1411691.4.peg.1849

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0179

Phylogenomic databases

eggNOGiENOG4105F1R Bacteria
COG0109 LUCA
HOGENOMiHOG000237290
InParanoidiP0AEA5
KOiK02257
PhylomeDBiP0AEA5

Enzyme and pathway databases

UniPathwayiUPA00834;UER00712
BioCyciEcoCyc:HEMEOSYN-MONOMER
ECOL316407:JW0418-MONOMER
MetaCyc:HEMEOSYN-MONOMER
BRENDAi2.5.1.B36 2026

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P0AEA5

Family and domain databases

CDDicd13957 PT_UbiA_Cox10, 1 hit
HAMAPiMF_00154 CyoE_CtaB, 1 hit
InterProiView protein in InterPro
IPR006369 Protohaem_IX_farnesylTrfase
IPR000537 UbiA_prenyltransferase
IPR030470 UbiA_prenylTrfase_CS
PANTHERiPTHR43448 PTHR43448, 1 hit
PfamiView protein in Pfam
PF01040 UbiA, 1 hit
TIGRFAMsiTIGR01473 cyoE_ctaB, 1 hit
PROSITEiView protein in PROSITE
PS00943 UBIA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCYOE_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0AEA5
Secondary accession number(s): P18404, P77115, Q2MBZ8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: November 13, 2019
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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