Curli production assembly/transport component CsgG

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• identical protein binding Source: EcoCyc <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Structural and mechanistic insights into the bacterial amyloid secretion channel CsgG."
    Goyal P., Krasteva P.V., Van Gerven N., Gubellini F., Van den Broeck I., Troupiotis-Tsailaki A., Jonckheere W., Pehau-Arnaudet G., Pinkner J.S., Chapman M.R., Hultgren S.J., Howorka S., Fronzes R., Remaut H.
    Nature 516:250-253(2014) [PubMed] [Europe PMC] [Abstract]
  • "Structure of the nonameric bacterial amyloid secretion channel."
    Cao B., Zhao Y., Kou Y., Ni D., Zhang X.C., Huang Y.
    Proc Natl Acad Sci U S A 111:E5439-44(2014) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• biological adhesion Source: EcoCyc <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.1

    "Expression of two csg operons is required for production of fibronectin- and congo red-binding curli polymers in Escherichia coli K-12."
    Hammar M., Arnqvist A., Bian Z., Olsen A., Normark S.
    Mol. Microbiol. 18:661-670(1995) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
• protein transmembrane transport Source: EcoCycInferred from mutant phenotypeⁱ
  • "Structure of the nonameric bacterial amyloid secretion channel."
    Cao B., Zhao Y., Kou Y., Ni D., Zhang X.C., Huang Y.
    Proc Natl Acad Sci U S A 111:E5439-44(2014) [PubMed] [Europe PMC] [Abstract]
  • "Availability of the fibre subunit CsgA and the nucleator protein CsgB during assembly of fibronectin-binding curli is limited by the intracellular concentration of the novel lipoprotein CsgG."
    Loferer H., Hammar M., Normark S.
    Mol Microbiol 26:11-23(1997) [PubMed] [Europe PMC] [Abstract]
• single-species biofilm formation Source: EcoCycInferred from mutant phenotypeⁱ
  • "Curli fibers are required for development of biofilm architecture in Escherichia coli K-12 and enhance bacterial adherence to human uroepithelial cells."
    Kikuchi T., Mizunoe Y., Takade A., Naito S., Yoshida S.
    Microbiol Immunol 49:875-884(2005) [PubMed] [Europe PMC] [Abstract]

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• identical protein binding Source: EcoCycInferred from direct assayⁱ
  • "Structural and mechanistic insights into the bacterial amyloid secretion channel CsgG."
    Goyal P., Krasteva P.V., Van Gerven N., Gubellini F., Van den Broeck I., Troupiotis-Tsailaki A., Jonckheere W., Pehau-Arnaudet G., Pinkner J.S., Chapman M.R., Hultgren S.J., Howorka S., Fronzes R., Remaut H.
    Nature 516:250-253(2014) [PubMed] [Europe PMC] [Abstract]
  • "Structure of the nonameric bacterial amyloid secretion channel."
    Cao B., Zhao Y., Kou Y., Ni D., Zhang X.C., Huang Y.
    Proc Natl Acad Sci U S A 111:E5439-44(2014) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MQRLFLLVAV MLLSGCLTAP PKEAARPTLM PRAQSYKDLT HLPAPTGKIF 
        60         70         80         90        100
VSVYNIQDET GQFKPYPASN FSTAVPQSAT AMLVTALKDS RWFIPLERQG 
       110        120        130        140        150
LQNLLNERKI IRAAQENGTV AINNRIPLQS LTAANIMVEG SIIGYESNVK 
       160        170        180        190        200
SGGVGARYFG IGADTQYQLD QIAVNLRVVN VSTGEILSSV NTSKTILSYE 
       210        220        230        240        250
VQAGVFRFID YQRLLEGEVG YTSNEPVMLC LMSAIETGVI FLINDGIDRG 
       260        270 
LWDLQNKAER QNDILVKYRH MSVPPES                          

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. SIMILARITY comments
   Index of protein domains and families