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UniProtKB - P0AE37 (ASTA_ECOLI)
Protein
Arginine N-succinyltransferase
Gene
astA
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalyzes the transfer of succinyl-CoA to arginine to produce N2-succinylarginine.
1 PublicationCatalytic activityi
- EC:2.3.1.109
: L-arginine degradation via AST pathway Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes L-glutamate and succinate from L-arginine. This subpathway is part of the pathway L-arginine degradation via AST pathway, which is itself part of Amino-acid degradation.View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate and succinate from L-arginine, the pathway L-arginine degradation via AST pathway and in Amino-acid degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 125 | Succinyl-CoA; via amide nitrogenSequence analysis | 1 | |
Active sitei | 229 | Proton donorSequence analysis | 1 |
GO - Molecular functioni
- arginine N-succinyltransferase activity Source: UniProtKB-UniRule
GO - Biological processi
- arginine catabolic process to glutamate Source: UniProtKB-UniRule
- arginine catabolic process to succinate Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Arginine metabolism, Stress response |
Enzyme and pathway databases
BioCyci | EcoCyc:ARGSUCCTRAN-MONOMER |
UniPathwayi | UPA00185;UER00279 |
Names & Taxonomyi
Protein namesi | Recommended name: Arginine N-succinyltransferase (EC:2.3.1.109)Short name: AST Alternative name(s): AOST |
Gene namesi | Name:astA Synonyms:ydjV Ordered Locus Names:b1747, JW1736 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000064712 | 1 – 344 | Arginine N-succinyltransferaseAdd BLAST | 344 |
Proteomic databases
jPOSTi | P0AE37 |
PaxDbi | P0AE37 |
PRIDEi | P0AE37 |
Expressioni
Inductioni
By nitrogen starvation, and arginine. Induced at stationary phase by sigma S.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4262235, 8 interactors |
IntActi | P0AE37, 6 interactors |
STRINGi | 511145.b1747 |
Family & Domainsi
Sequence similaritiesi
Belongs to the arginine N-succinyltransferase family.Curated
Phylogenomic databases
eggNOGi | COG3138, Bacteria |
HOGENOMi | CLU_057655_0_0_6 |
InParanoidi | P0AE37 |
OMAi | RFFSMEF |
PhylomeDBi | P0AE37 |
Family and domain databases
HAMAPi | MF_01171, AstA, 1 hit |
InterProi | View protein in InterPro IPR016181, Acyl_CoA_acyltransferase IPR007041, Arg_succinylTrfase_AstA/AruG IPR017650, Arginine_N-succinylTrfase |
Pfami | View protein in Pfam PF04958, AstA, 1 hit |
SUPFAMi | SSF55729, SSF55729, 1 hit |
TIGRFAMsi | TIGR03243, arg_catab_AOST, 1 hit TIGR03244, arg_catab_AstA, 1 hit |
i Sequence
Sequence statusi: Complete.
P0AE37-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMVIRPVERS DVSALMQLAS KTGGGLTSLP ANEATLSARI ERAIKTWQGE
60 70 80 90 100
LPKSEQGYVF VLEDSETGTV AGICAIEVAV GLNDPWYNYR VGTLVHASKE
110 120 130 140 150
LNVYNALPTL FLSNDHTGSS ELCTLFLDPD WRKEGNGYLL SKSRFMFMAA
160 170 180 190 200
FRDKFNDKVV AEMRGVIDEH GYSPFWQSLG KRFFSMDFSR ADFLCGTGQK
210 220 230 240 250
AFIAELMPKH PIYTHFLSQE AQDVIGQVHP QTAPARAVLE KEGFRYRNYI
260 270 280 290 300
DIFDGGPTLE CDIDRVRAIR KSRLVEVAEG QPAQGDFPAC LVANENYHHF
310 320 330 340
RVVLVRTDPA TERLILTAAQ LDALKCHAGD RVRLVRLCAE EKTA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74817.1 AP009048 Genomic DNA Translation: BAE76517.1 |
PIRi | C64934 |
RefSeqi | NP_416261.1, NC_000913.3 WP_000989419.1, NZ_SSZK01000001.1 |
Genome annotation databases
EnsemblBacteriai | AAC74817; AAC74817; b1747 BAE76517; BAE76517; BAE76517 |
GeneIDi | 946261 |
KEGGi | ecj:JW1736 eco:b1747 |
PATRICi | fig|1411691.4.peg.509 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74817.1 AP009048 Genomic DNA Translation: BAE76517.1 |
PIRi | C64934 |
RefSeqi | NP_416261.1, NC_000913.3 WP_000989419.1, NZ_SSZK01000001.1 |
3D structure databases
AlphaFoldDBi | P0AE37 |
SMRi | P0AE37 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4262235, 8 interactors |
IntActi | P0AE37, 6 interactors |
STRINGi | 511145.b1747 |
Proteomic databases
jPOSTi | P0AE37 |
PaxDbi | P0AE37 |
PRIDEi | P0AE37 |
Genome annotation databases
EnsemblBacteriai | AAC74817; AAC74817; b1747 BAE76517; BAE76517; BAE76517 |
GeneIDi | 946261 |
KEGGi | ecj:JW1736 eco:b1747 |
PATRICi | fig|1411691.4.peg.509 |
Organism-specific databases
EchoBASEi | EB3754 |
Phylogenomic databases
eggNOGi | COG3138, Bacteria |
HOGENOMi | CLU_057655_0_0_6 |
InParanoidi | P0AE37 |
OMAi | RFFSMEF |
PhylomeDBi | P0AE37 |
Enzyme and pathway databases
UniPathwayi | UPA00185;UER00279 |
BioCyci | EcoCyc:ARGSUCCTRAN-MONOMER |
Miscellaneous databases
PROi | PR:P0AE37 |
Family and domain databases
HAMAPi | MF_01171, AstA, 1 hit |
InterProi | View protein in InterPro IPR016181, Acyl_CoA_acyltransferase IPR007041, Arg_succinylTrfase_AstA/AruG IPR017650, Arginine_N-succinylTrfase |
Pfami | View protein in Pfam PF04958, AstA, 1 hit |
SUPFAMi | SSF55729, SSF55729, 1 hit |
TIGRFAMsi | TIGR03243, arg_catab_AOST, 1 hit TIGR03244, arg_catab_AstA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ASTA_ECOLI | |
Accessioni | P0AE37Primary (citable) accession number: P0AE37 Secondary accession number(s): P76218, Q2MB39 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2005 |
Last sequence update: | December 6, 2005 | |
Last modified: | May 25, 2022 | |
This is version 113 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families