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Entry version 109 (12 Aug 2020)
Sequence version 1 (06 Dec 2005)
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Protein

Arginine ABC transporter permease protein ArtM

Gene

artM

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Probably responsible for the translocation of the substrate across the membrane.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:ARTM-MONOMER
ECOL316407:JW0845-MONOMER
MetaCyc:ARTM-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.3.3, the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Arginine ABC transporter permease protein ArtM
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:artM
Ordered Locus Names:b0861, JW0845
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 15PeriplasmicSequence analysisAdd BLAST15
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei16 – 36HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini37 – 49CytoplasmicSequence analysisAdd BLAST13
Transmembranei50 – 70HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini71 – 79PeriplasmicSequence analysis9
Transmembranei80 – 100HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini101 – 154CytoplasmicSequence analysisAdd BLAST54
Transmembranei155 – 175HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini176 – 186PeriplasmicSequence analysisAdd BLAST11
Transmembranei187 – 207HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini208 – 222CytoplasmicSequence analysisAdd BLAST15

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000599571 – 222Arginine ABC transporter permease protein ArtMAdd BLAST222

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P0AE30

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0AE30

PRoteomics IDEntifications database

More...
PRIDEi
P0AE30

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The complex is composed of two ATP-binding proteins (ArtP), two transmembrane proteins (ArtM and ArtQ) and two solute-binding proteins (ArtJ and ArtI).

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4263352, 13 interactors
853308, 1 interactor

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-4318, Arginine ABC transporter complex, artI variant
CPX-4319, Arginine ABC transporter complex, artJ variant

Database of interacting proteins

More...
DIPi
DIP-48169N

Protein interaction database and analysis system

More...
IntActi
P0AE30, 2 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b0861

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 208ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST197

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG4160, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_019602_1_4_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0AE30

KEGG Orthology (KO)

More...
KOi
K09998

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0AE30

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06261, TM_PBP2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.3720.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010065, AA_ABC_transptr_permease_3TM
IPR043429, ArtM/GltK/GlnP/TcyL/YhdX-like
IPR000515, MetI-like
IPR035906, MetI-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR30614, PTHR30614, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00528, BPD_transp_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF161098, SSF161098, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01726, HEQRo_perm_3TM, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50928, ABC_TM1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0AE30-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFEYLPELMK GLHTSLTLTV ASLIVALILA LIFTIILTLK TPVLVWLVRG
60 70 80 90 100
YITLFTGTPL LVQIFLIYYG PGQFPTLQEY PALWHLLSEP WLCALIALSL
110 120 130 140 150
NSAAYTTQLF YGAIRAIPEG QWQSCSALGM SKKDTLAILL PYAFKRSLSS
160 170 180 190 200
YSNEVVLVFK STSLAYTITL MEVMGYSQLL YGRTYDVMVF GAAGIIYLVV
210 220
NGLLTLMMRL IERKALAFER RN
Length:222
Mass (Da):24,914
Last modified:December 6, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE9AEF4221C662EDE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti63Q → R in CAA60104 (PubMed:8501075).Curated1
Sequence conflicti100L → V in CAA60104 (PubMed:8501075).Curated1
Sequence conflicti216L → V in CAA60104 (PubMed:8501075).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X86160 Genomic DNA Translation: CAA60104.1
U00096 Genomic DNA Translation: AAC73948.1
AP009048 Genomic DNA Translation: BAA35575.1

Protein sequence database of the Protein Information Resource

More...
PIRi
E64824

NCBI Reference Sequences

More...
RefSeqi
NP_415382.1, NC_000913.3
WP_000464491.1, NZ_STEB01000019.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC73948; AAC73948; b0861
BAA35575; BAA35575; BAA35575

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
49585390
949066

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW0845
eco:b0861

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.1416

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86160 Genomic DNA Translation: CAA60104.1
U00096 Genomic DNA Translation: AAC73948.1
AP009048 Genomic DNA Translation: BAA35575.1
PIRiE64824
RefSeqiNP_415382.1, NC_000913.3
WP_000464491.1, NZ_STEB01000019.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4263352, 13 interactors
853308, 1 interactor
ComplexPortaliCPX-4318, Arginine ABC transporter complex, artI variant
CPX-4319, Arginine ABC transporter complex, artJ variant
DIPiDIP-48169N
IntActiP0AE30, 2 interactors
STRINGi511145.b0861

Protein family/group databases

TCDBi3.A.1.3.3, the atp-binding cassette (abc) superfamily

Proteomic databases

jPOSTiP0AE30
PaxDbiP0AE30
PRIDEiP0AE30

Genome annotation databases

EnsemblBacteriaiAAC73948; AAC73948; b0861
BAA35575; BAA35575; BAA35575
GeneIDi49585390
949066
KEGGiecj:JW0845
eco:b0861
PATRICifig|1411691.4.peg.1416

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB1584

Phylogenomic databases

eggNOGiCOG4160, Bacteria
HOGENOMiCLU_019602_1_4_6
InParanoidiP0AE30
KOiK09998
PhylomeDBiP0AE30

Enzyme and pathway databases

BioCyciEcoCyc:ARTM-MONOMER
ECOL316407:JW0845-MONOMER
MetaCyc:ARTM-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P0AE30

Family and domain databases

CDDicd06261, TM_PBP2, 1 hit
Gene3Di1.10.3720.10, 1 hit
InterProiView protein in InterPro
IPR010065, AA_ABC_transptr_permease_3TM
IPR043429, ArtM/GltK/GlnP/TcyL/YhdX-like
IPR000515, MetI-like
IPR035906, MetI-like_sf
PANTHERiPTHR30614, PTHR30614, 1 hit
PfamiView protein in Pfam
PF00528, BPD_transp_1, 1 hit
SUPFAMiSSF161098, SSF161098, 1 hit
TIGRFAMsiTIGR01726, HEQRo_perm_3TM, 1 hit
PROSITEiView protein in PROSITE
PS50928, ABC_TM1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARTM_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0AE30
Secondary accession number(s): P30862, P77311
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: August 12, 2020
This is version 109 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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