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UniProtKB - P0AE25 (ARAE_ECO57)
Protein
Arabinose-proton symporter
Gene
araE
Organism
Escherichia coli O157:H7
Status
Functioni
Uptake of arabinose across the boundary membrane with the concomitant transport of protons into the cell (symport system).
By similarityGO - Molecular functioni
- symporter activity Source: UniProtKB-KW
GO - Biological processi
- carbohydrate transport Source: UniProtKB-KW
Keywordsi
Biological process | Sugar transport, Symport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Arabinose-proton symporterAlternative name(s): Arabinose transporter |
Gene namesi | Name:araE Ordered Locus Names:Z4161, ECs3698 |
Organismi | Escherichia coli O157:H7 |
Taxonomic identifieri | 83334 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 29 | CytoplasmicSequence analysisAdd BLAST | 29 | |
Transmembranei | 30 – 50 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 51 – 63 | PeriplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 64 – 84 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 85 – 91 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 92 – 112 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 113 – 114 | PeriplasmicSequence analysis | 2 | |
Transmembranei | 115 – 135 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 136 – 154 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 155 – 175 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 176 – 178 | PeriplasmicSequence analysis | 3 | |
Transmembranei | 179 – 199 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 200 – 257 | CytoplasmicSequence analysisAdd BLAST | 58 | |
Transmembranei | 258 – 278 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 279 – 297 | PeriplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 298 – 318 | Helical; Name=8Sequence analysisAdd BLAST | 21 | |
Topological domaini | 319 – 325 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 326 – 346 | Helical; Name=9Sequence analysisAdd BLAST | 21 | |
Topological domaini | 347 – 361 | PeriplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 362 – 382 | Helical; Name=10Sequence analysisAdd BLAST | 21 | |
Topological domaini | 383 – 404 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 405 – 425 | Helical; Name=11Sequence analysisAdd BLAST | 21 | |
Topological domaini | 426 – 427 | PeriplasmicSequence analysis | 2 | |
Transmembranei | 428 – 446 | Helical; Name=12Sequence analysisAdd BLAST | 19 | |
Topological domaini | 447 – 472 | CytoplasmicSequence analysisAdd BLAST | 26 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050290 | 1 – 472 | Arabinose-proton symporterAdd BLAST | 472 |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2814, Bacteria |
HOGENOMi | CLU_001265_30_5_6 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P0AE25-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVTINTESAL TPRSLRDTRR MNMFVSVAAA VAGLLFGLDI GVIAGALPFI
60 70 80 90 100
TDHFVLTSRL QEWVVSSMML GAAIGALFNG WLSFRLGRKY SLMAGAILFV
110 120 130 140 150
LGSIGSAFAT SVEMLIAARV VLGIAVGIAS YTAPLYLSEM ASENVRGKMI
160 170 180 190 200
SMYQLMVTLG IVLAFLSDTA FSYSGNWRAM LGVLALPAVL LIILVVFLPN
210 220 230 240 250
SPRWLAEKGR HIEAEEVLRM LRDTSEKARE ELNEIRESLK LKQGGWALFK
260 270 280 290 300
INRNVRRAVF LGMLLQAMQQ FTGMNIIMYY APRIFKMAGF TTTEQQMIAT
310 320 330 340 350
LVVGLTFMFA TFIAVFTVDK AGRKPALKIG FSVMALGTLV LGYCLMQFDN
360 370 380 390 400
GTASSGLSWL SVGMTMMCIA GYAMSAAPVV WILCSEIQPL KCRDFGITCS
410 420 430 440 450
TTTNWVSNMI IGATFLTLLD SIGAAGTFWL YTALNIAFVG ITFWLIPETK
460 470
NVTLEHIERK LMAGEKLRNI GV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE005174 Genomic DNA Translation: AAG57953.1 BA000007 Genomic DNA Translation: BAB37121.1 |
PIRi | B91091 E85936 |
RefSeqi | NP_311725.1, NC_002695.1 WP_000256438.1, NZ_SWKA01000005.1 |
Genome annotation databases
EnsemblBacteriai | AAG57953; AAG57953; Z4161 BAB37121; BAB37121; ECs_3698 |
GeneIDi | 66673292 916479 |
KEGGi | ece:Z4161 ecs:ECs3698 |
PATRICi | fig|386585.9.peg.3865 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE005174 Genomic DNA Translation: AAG57953.1 BA000007 Genomic DNA Translation: BAB37121.1 |
PIRi | B91091 E85936 |
RefSeqi | NP_311725.1, NC_002695.1 WP_000256438.1, NZ_SWKA01000005.1 |
3D structure databases
SMRi | P0AE25 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 386585.gene:10366763 |
Genome annotation databases
EnsemblBacteriai | AAG57953; AAG57953; Z4161 BAB37121; BAB37121; ECs_3698 |
GeneIDi | 66673292 916479 |
KEGGi | ece:Z4161 ecs:ECs3698 |
PATRICi | fig|386585.9.peg.3865 |
Phylogenomic databases
eggNOGi | COG2814, Bacteria |
HOGENOMi | CLU_001265_30_5_6 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ARAE_ECO57 | |
Accessioni | P0AE25Primary (citable) accession number: P0AE25 Secondary accession number(s): P09830, Q46937 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2005 |
Last sequence update: | December 6, 2005 | |
Last modified: | February 23, 2022 | |
This is version 98 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families