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Protein

Protein AmpG

Gene

ampG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably acts as a permease in the beta-lactamase induction system and in peptidoglycan recycling.

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:AMPG-MONOMER
MetaCyc:AMPG-MONOMER

Protein family/group databases

TCDBi2.A.1.25.2 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Protein AmpG
Gene namesi
Name:ampG
Ordered Locus Names:b0433, JW0423
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12183 ampG

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Topological domaini34 – 80PeriplasmicSequence analysisAdd BLAST47
Transmembranei81 – 105HelicalSequence analysisAdd BLAST25
Topological domaini106 – 109CytoplasmicSequence analysis4
Transmembranei110 – 128HelicalSequence analysisAdd BLAST19
Topological domaini129 – 173PeriplasmicSequence analysisAdd BLAST45
Transmembranei174 – 197HelicalSequence analysisAdd BLAST24
Topological domaini198 – 223CytoplasmicSequence analysisAdd BLAST26
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Topological domaini245 – 265PeriplasmicSequence analysisAdd BLAST21
Transmembranei266 – 283HelicalSequence analysisAdd BLAST18
Topological domaini284 – 327CytoplasmicSequence analysisAdd BLAST44
Transmembranei328 – 345HelicalSequence analysisAdd BLAST18
Topological domaini346 – 381PeriplasmicSequence analysisAdd BLAST36
Transmembranei382 – 406HelicalSequence analysisAdd BLAST25
Topological domaini407 – 424CytoplasmicSequence analysisAdd BLAST18
Transmembranei425 – 450HelicalSequence analysisAdd BLAST26
Topological domaini451 – 460PeriplasmicSequence analysis10
Transmembranei461 – 485HelicalSequence analysisAdd BLAST25
Topological domaini486 – 491CytoplasmicSequence analysis6

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000848301 – 491Protein AmpGAdd BLAST491

Proteomic databases

PaxDbiP0AE16
PRIDEiP0AE16

Interactioni

Protein-protein interaction databases

BioGridi4259838, 195 interactors
STRINGi316385.ECDH10B_0389

Structurei

3D structure databases

ProteinModelPortaliP0AE16
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EYM Bacteria
COG0477 LUCA
HOGENOMiHOG000217208
InParanoidiP0AE16
KOiK08218
OMAiSWVGLAY
PhylomeDBiP0AE16

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR004752 AmpG_permease/AT-1
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00901 2A0125, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

P0AE16-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSQYLRIFQ QPRSAILLIL GFASGLPLAL TSGTLQAWMT VENIDLKTIG
60 70 80 90 100
FFSLVGQAYV FKFLWSPLMD RYTPPFFGRR RGWLLATQIL LLVAIAAMGF
110 120 130 140 150
LEPGTQLRWM AALAVVIAFC SASQDIVFDA WKTDVLPAEE RGAGAAISVL
160 170 180 190 200
GYRLGMLVSG GLALWLADKW LGWQGMYWLM AALLIPCIIA TLLAPEPTDT
210 220 230 240 250
IPVPKTLEQA VVAPLRDFFG RNNAWLILLL IVLYKLGDAF AMSLTTTFLI
260 270 280 290 300
RGVGFDAGEV GVVNKTLGLL ATIVGALYGG ILMQRLSLFR ALLIFGILQG
310 320 330 340 350
ASNAGYWLLS ITDKHLYSMG AAVFFENLCG GMGTSAFVAL LMTLCNKSFS
360 370 380 390 400
ATQFALLSAL SAVGRVYVGP VAGWFVEAHG WSTFYLFSVA AAVPGLILLL
410 420 430 440 450
VCRQTLEYTR VNDNFISRTA YPAGYAFAMW TLAAGVSLLA VWLLLLTMDA
460 470 480 490
LDLTHFSFLP ALLEVGVLVA LSGVVLGGLL DYLALRKTHL T
Length:491
Mass (Da):53,245
Last modified:December 6, 2005 - v1
Checksum:i6B0D7E2BC699CA9C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti151G → D in non-inducible mutant SN0301-1. 1
Natural varianti268G → D in non-inducible mutant SN0301-3. 1
Natural varianti373G → D in non-inducible mutant SN0301-5. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S67816 Genomic DNA Translation: AAB28884.1
X82158 mRNA Translation: CAA57651.1
X82159 mRNA Translation: CAA57652.1
X82160 mRNA Translation: CAA57653.1
U82664 Genomic DNA Translation: AAB40189.1
U00096 Genomic DNA Translation: AAC73536.1
AP009048 Genomic DNA Translation: BAE76213.1
PIRiS37391
RefSeqiNP_414967.1, NC_000913.3
WP_000098429.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73536; AAC73536; b0433
BAE76213; BAE76213; BAE76213
GeneIDi946438
KEGGiecj:JW0423
eco:b0433
PATRICifig|1411691.4.peg.1844

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S67816 Genomic DNA Translation: AAB28884.1
X82158 mRNA Translation: CAA57651.1
X82159 mRNA Translation: CAA57652.1
X82160 mRNA Translation: CAA57653.1
U82664 Genomic DNA Translation: AAB40189.1
U00096 Genomic DNA Translation: AAC73536.1
AP009048 Genomic DNA Translation: BAE76213.1
PIRiS37391
RefSeqiNP_414967.1, NC_000913.3
WP_000098429.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP0AE16
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259838, 195 interactors
STRINGi316385.ECDH10B_0389

Protein family/group databases

TCDBi2.A.1.25.2 the major facilitator superfamily (mfs)

Proteomic databases

PaxDbiP0AE16
PRIDEiP0AE16

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73536; AAC73536; b0433
BAE76213; BAE76213; BAE76213
GeneIDi946438
KEGGiecj:JW0423
eco:b0433
PATRICifig|1411691.4.peg.1844

Organism-specific databases

EchoBASEiEB2100
EcoGeneiEG12183 ampG

Phylogenomic databases

eggNOGiENOG4105EYM Bacteria
COG0477 LUCA
HOGENOMiHOG000217208
InParanoidiP0AE16
KOiK08218
OMAiSWVGLAY
PhylomeDBiP0AE16

Enzyme and pathway databases

BioCyciEcoCyc:AMPG-MONOMER
MetaCyc:AMPG-MONOMER

Miscellaneous databases

PROiPR:P0AE16

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR004752 AmpG_permease/AT-1
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00901 2A0125, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAMPG_ECOLI
AccessioniPrimary (citable) accession number: P0AE16
Secondary accession number(s): P36670, Q2MBZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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Main funding by: National Institutes of Health

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