ampG

Functionⁱ

Probably acts as a permease in the beta-lactamase induction system and in peptidoglycan recycling.

GO - Biological processⁱ

transmembrane transport Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transport

Biological process

Transport

Enzyme and pathway databases

BioCycⁱ	EcoCyc:AMPG-MONOMER MetaCyc:AMPG-MONOMER

BioCycⁱ

EcoCyc:AMPG-MONOMER
MetaCyc:AMPG-MONOMER

Protein family/group databases

TCDBⁱ	2.A.1.25.2 the major facilitator superfamily (mfs)

TCDBⁱ

2.A.1.25.2 the major facilitator superfamily (mfs)

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein AmpG
Gene namesⁱ	Name:ampG Ordered Locus Names:b0433, JW0423
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG12183 ampG

EcoGeneⁱ

EG12183 ampG

Subcellular locationⁱ

Cell inner membrane ; Multi-pass membrane protein

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 12	CytoplasmicSequence analysisAdd BLAST	12
Transmembraneⁱ	13 – 33	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	34 – 80	PeriplasmicSequence analysisAdd BLAST	47
Transmembraneⁱ	81 – 105	HelicalSequence analysisAdd BLAST	25
Topological domainⁱ	106 – 109	CytoplasmicSequence analysis	4
Transmembraneⁱ	110 – 128	HelicalSequence analysisAdd BLAST	19
Topological domainⁱ	129 – 173	PeriplasmicSequence analysisAdd BLAST	45
Transmembraneⁱ	174 – 197	HelicalSequence analysisAdd BLAST	24
Topological domainⁱ	198 – 223	CytoplasmicSequence analysisAdd BLAST	26
Transmembraneⁱ	224 – 244	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	245 – 265	PeriplasmicSequence analysisAdd BLAST	21
Transmembraneⁱ	266 – 283	HelicalSequence analysisAdd BLAST	18
Topological domainⁱ	284 – 327	CytoplasmicSequence analysisAdd BLAST	44
Transmembraneⁱ	328 – 345	HelicalSequence analysisAdd BLAST	18
Topological domainⁱ	346 – 381	PeriplasmicSequence analysisAdd BLAST	36
Transmembraneⁱ	382 – 406	HelicalSequence analysisAdd BLAST	25
Topological domainⁱ	407 – 424	CytoplasmicSequence analysisAdd BLAST	18
Transmembraneⁱ	425 – 450	HelicalSequence analysisAdd BLAST	26
Topological domainⁱ	451 – 460	PeriplasmicSequence analysis	10
Transmembraneⁱ	461 – 485	HelicalSequence analysisAdd BLAST	25
Topological domainⁱ	486 – 491	CytoplasmicSequence analysis	6

GO - Cellular componentⁱ

integral component of plasma membrane Source: GO_Central
plasma membrane
Source: EcoCyc
Inferred from direct assayⁱ
- 15919996

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell inner membrane, Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000084830	1 – 491	Protein AmpGAdd BLAST		491

Proteomic databases

PaxDbⁱ	P0AE16
PRIDEⁱ	P0AE16

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	4259838, 195 interactors
STRINGⁱ	316385.ECDH10B_0389

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P0AE16
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the major facilitator superfamily.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG4105EYM Bacteria COG0477 LUCA
HOGENOMⁱ	HOG000217208
InParanoidⁱ	P0AE16
KEGG Orthology (KO) More...KOⁱ	K08218
OMAⁱ	SWVGLAY
PhylomeDBⁱ	P0AE16

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06174 MFS, 1 hit
InterProⁱ	View protein in InterPro IPR004752 AmpG_permease/AT-1 IPR011701 MFS IPR020846 MFS_dom IPR036259 MFS_trans_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07690 MFS_1, 1 hit
SUPFAMⁱ	SSF103473 SSF103473, 1 hit
TIGRFAMsⁱ	TIGR00901 2A0125, 1 hit
PROSITEⁱ	View protein in PROSITE PS50850 MFS, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P0AE16-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSQYLRIFQ QPRSAILLIL GFASGLPLAL TSGTLQAWMT VENIDLKTIG 
        60         70         80         90        100
FFSLVGQAYV FKFLWSPLMD RYTPPFFGRR RGWLLATQIL LLVAIAAMGF 
       110        120        130        140        150
LEPGTQLRWM AALAVVIAFC SASQDIVFDA WKTDVLPAEE RGAGAAISVL 
       160        170        180        190        200
GYRLGMLVSG GLALWLADKW LGWQGMYWLM AALLIPCIIA TLLAPEPTDT 
       210        220        230        240        250
IPVPKTLEQA VVAPLRDFFG RNNAWLILLL IVLYKLGDAF AMSLTTTFLI 
       260        270        280        290        300
RGVGFDAGEV GVVNKTLGLL ATIVGALYGG ILMQRLSLFR ALLIFGILQG 
       310        320        330        340        350
ASNAGYWLLS ITDKHLYSMG AAVFFENLCG GMGTSAFVAL LMTLCNKSFS 
       360        370        380        390        400
ATQFALLSAL SAVGRVYVGP VAGWFVEAHG WSTFYLFSVA AAVPGLILLL 
       410        420        430        440        450
VCRQTLEYTR VNDNFISRTA YPAGYAFAMW TLAAGVSLLA VWLLLLTMDA 
       460        470        480        490 
LDLTHFSFLP ALLEVGVLVA LSGVVLGGLL DYLALRKTHL T

Length:491

Mass (Da):53,245

Last modified:December 6, 2005 - v1

Checksum:ⁱ6B0D7E2BC699CA9C

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱ	151	G → D in non-inducible mutant SN0301-1.	1
Natural variantⁱ	268	G → D in non-inducible mutant SN0301-3.	1
Natural variantⁱ	373	G → D in non-inducible mutant SN0301-5.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S67816 Genomic DNA Translation: AAB28884.1 X82158 mRNA Translation: CAA57651.1 X82159 mRNA Translation: CAA57652.1 X82160 mRNA Translation: CAA57653.1 U82664 Genomic DNA Translation: AAB40189.1 U00096 Genomic DNA Translation: AAC73536.1 AP009048 Genomic DNA Translation: BAE76213.1
PIRⁱ	S37391
NCBI Reference Sequences More...RefSeqⁱ	NP_414967.1, NC_000913.3 WP_000098429.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC73536; AAC73536; b0433 BAE76213; BAE76213; BAE76213
GeneIDⁱ	946438
KEGGⁱ	ecj:JW0423 eco:b0433
PATRICⁱ	fig\|1411691.4.peg.1844

Protein	Similar proteins		Species	Score	Length	Source
P0AE16	Protein AmpG		ECO57		491	UniRef100_P0AE17
Muropeptide MFS transporter AmpG		Escherichia coli O145 str. RM9872		491
AmpG family muropeptide MFS transporter		ECOLX		491
Muropeptide MFS transporter AmpG		SHIBO		491
Muropeptide MFS transporter AmpG		SHIDY		491
+29

Protein	Similar proteins		Species	Score	Length	Source
P0AE16	Protein AmpG		ECO57		491	UniRef90_P0AE17
Muropeptide MFS transporter AmpG		Escherichia coli O145 str. RM9872		491
AmpG family muropeptide MFS transporter		ECOLX		491
Muropeptide MFS transporter AmpG		SHIBO		491
Muropeptide MFS transporter AmpG		SHIDY		491
+646

Protein	Similar proteins		Species	Score	Length	Source
P0AE16	Protein AmpG		ECO57		491	UniRef50_P0AE17
Muropeptide MFS transporter AmpG		Escherichia coli O145 str. RM9872		491
AmpG family muropeptide MFS transporter		ECOLX		491
Muropeptide MFS transporter AmpG		SHIBO		491
Muropeptide MFS transporter AmpG		SHIDY		491
+2671

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S67816 Genomic DNA Translation: AAB28884.1 X82158 mRNA Translation: CAA57651.1 X82159 mRNA Translation: CAA57652.1 X82160 mRNA Translation: CAA57653.1 U82664 Genomic DNA Translation: AAB40189.1 U00096 Genomic DNA Translation: AAC73536.1 AP009048 Genomic DNA Translation: BAE76213.1
PIRⁱ	S37391
RefSeqⁱ	NP_414967.1, NC_000913.3 WP_000098429.1, NZ_LN832404.1

3D structure databases

ProteinModelPortalⁱ	P0AE16
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4259838, 195 interactors
STRINGⁱ	316385.ECDH10B_0389

Protein family/group databases

TCDBⁱ	2.A.1.25.2 the major facilitator superfamily (mfs)

TCDBⁱ

2.A.1.25.2 the major facilitator superfamily (mfs)

Proteomic databases

PaxDbⁱ	P0AE16
PRIDEⁱ	P0AE16

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC73536; AAC73536; b0433 BAE76213; BAE76213; BAE76213
GeneIDⁱ	946438
KEGGⁱ	ecj:JW0423 eco:b0433
PATRICⁱ	fig\|1411691.4.peg.1844

Organism-specific databases

EchoBASEⁱ	EB2100
EcoGeneⁱ	EG12183 ampG

Phylogenomic databases

eggNOGⁱ	ENOG4105EYM Bacteria COG0477 LUCA
HOGENOMⁱ	HOG000217208
InParanoidⁱ	P0AE16
KOⁱ	K08218
OMAⁱ	SWVGLAY
PhylomeDBⁱ	P0AE16

Enzyme and pathway databases

BioCycⁱ	EcoCyc:AMPG-MONOMER MetaCyc:AMPG-MONOMER

BioCycⁱ

EcoCyc:AMPG-MONOMER
MetaCyc:AMPG-MONOMER

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P0AE16

PROⁱ

PR:P0AE16

Family and domain databases

CDDⁱ	cd06174 MFS, 1 hit
InterProⁱ	View protein in InterPro IPR004752 AmpG_permease/AT-1 IPR011701 MFS IPR020846 MFS_dom IPR036259 MFS_trans_sf
Pfamⁱ	View protein in Pfam PF07690 MFS_1, 1 hit
SUPFAMⁱ	SSF103473 SSF103473, 1 hit
TIGRFAMsⁱ	TIGR00901 2A0125, 1 hit
PROSITEⁱ	View protein in PROSITE PS50850 MFS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AMPG_ECOLI
Accessionⁱ	P0AE16Primary (citable) accession number: P0AE16 Secondary accession number(s): P36670, Q2MBZ3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
	Last sequence update:	December 6, 2005
	Last modified:	March 28, 2018
	This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P0AE16 (AMPG_ECOLI)

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Protein AmpG

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ