UniProtKB - P0ADW6 (YHCC_ECOLI)
Protein
Protein YhcC
Gene
yhcC
Organism
Escherichia coli (strain K12)
Status
Functioni
In vitro, can cleave S-adenosyl-L-methionine into methionine and 5'-deoxyadenosine (AdoH).1 Publication
Cofactori
[4Fe-4S] cluster1 PublicationNote: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 33 | Iron-sulfur (4Fe-4S-S-AdoMet)By similarity | 1 | |
Metal bindingi | 45 | Iron-sulfur (4Fe-4S-S-AdoMet)By similarity | 1 | |
Metal bindingi | 48 | Iron-sulfur (4Fe-4S-S-AdoMet)By similarity | 1 |
GO - Molecular functioni
- 4 iron, 4 sulfur cluster binding Source: EcoCyc
- catalytic activity Source: InterPro
- metal ion binding Source: UniProtKB-KW
Keywordsi
Ligand | 4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine |
Enzyme and pathway databases
BioCyci | EcoCyc:G7669-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Protein YhcCCurated |
Gene namesi | Name:yhcC Ordered Locus Names:b3211, JW3178 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000169481 | 1 – 309 | Protein YhcCAdd BLAST | 309 |
Proteomic databases
PaxDbi | P0ADW6 |
PRIDEi | P0ADW6 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4262426, 7 interactors 852046, 1 interactor |
DIPi | DIP-48274N |
IntActi | P0ADW6, 10 interactors |
STRINGi | 511145.b3211 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 17 – 254 | Radical SAM corePROSITE-ProRule annotationAdd BLAST | 238 |
Sequence similaritiesi
Belongs to the radical SAM superfamily.Curated
Phylogenomic databases
eggNOGi | COG1242, Bacteria |
HOGENOMi | CLU_060920_0_0_6 |
InParanoidi | P0ADW6 |
PhylomeDBi | P0ADW6 |
Family and domain databases
Gene3Di | 3.80.30.20, 1 hit |
InterProi | View protein in InterPro IPR039661, ELP3 IPR006638, Elp3/MiaB/NifB IPR032432, Radical_SAM_C IPR007197, rSAM IPR023404, rSAM_horseshoe IPR005911, YhcC-like |
PANTHERi | PTHR11135, PTHR11135, 1 hit PTHR11135:SF1, PTHR11135:SF1, 1 hit |
Pfami | View protein in Pfam PF04055, Radical_SAM, 1 hit PF16199, Radical_SAM_C, 1 hit |
SFLDi | SFLDS00029, Radical_SAM, 1 hit SFLDG01091, uncharacterized_CHP01210-like, 1 hit |
SMARTi | View protein in SMART SM00729, Elp3, 1 hit |
TIGRFAMsi | TIGR01212, TIGR01212, 1 hit |
PROSITEi | View protein in PROSITE PS51918, RADICAL_SAM, 1 hit |
i Sequence
Sequence statusi: Complete.
P0ADW6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQLQKLVNMF GGDLTRRYGQ KVHKLTLHGG FSCPNRDGTI GRGGCTFCNV
60 70 80 90 100
ASFADEAQQH RSIAEQLAHQ ANLVNRAKRY LAYFQAYTST FAEVQVLRSM
110 120 130 140 150
YQQAVSQANI VGLCVGTRPD CVPDAVLDLL CEYKDQGYEV WLELGLQTAH
160 170 180 190 200
DKTLHRINRG HDFACYQRTT QLARQRGLKV CSHLIVGLPG EGQAECLQTL
210 220 230 240 250
ERVVETGVDG IKLHPLHIVK GSIMAKAWEA GRLNGIELED YTLTAGEMIR
260 270 280 290 300
HTPPEVIYHR ISASARRPTL LAPLWCENRW TGMVELDRYL NEHGVQGSAL
GRPWLPPTE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 24 – 25 | KL → NV in L20253 (PubMed:7901196).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18997 Genomic DNA Translation: AAA58013.1 Sequence problems. U00096 Genomic DNA Translation: AAC76243.1 AP009048 Genomic DNA Translation: BAE77255.1 L20253 Genomic DNA No translation available. |
PIRi | E65112 |
RefSeqi | NP_417678.1, NC_000913.3 WP_001299745.1, NZ_SSZK01000007.1 |
Genome annotation databases
EnsemblBacteriai | AAC76243; AAC76243; b3211 BAE77255; BAE77255; BAE77255 |
GeneIDi | 48134024 947733 |
KEGGi | ecj:JW3178 eco:b3211 |
PATRICi | fig|1411691.4.peg.3518 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18997 Genomic DNA Translation: AAA58013.1 Sequence problems. U00096 Genomic DNA Translation: AAC76243.1 AP009048 Genomic DNA Translation: BAE77255.1 L20253 Genomic DNA No translation available. |
PIRi | E65112 |
RefSeqi | NP_417678.1, NC_000913.3 WP_001299745.1, NZ_SSZK01000007.1 |
3D structure databases
SMRi | P0ADW6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4262426, 7 interactors 852046, 1 interactor |
DIPi | DIP-48274N |
IntActi | P0ADW6, 10 interactors |
STRINGi | 511145.b3211 |
Proteomic databases
PaxDbi | P0ADW6 |
PRIDEi | P0ADW6 |
Genome annotation databases
EnsemblBacteriai | AAC76243; AAC76243; b3211 BAE77255; BAE77255; BAE77255 |
GeneIDi | 48134024 947733 |
KEGGi | ecj:JW3178 eco:b3211 |
PATRICi | fig|1411691.4.peg.3518 |
Organism-specific databases
EchoBASEi | EB2660 |
Phylogenomic databases
eggNOGi | COG1242, Bacteria |
HOGENOMi | CLU_060920_0_0_6 |
InParanoidi | P0ADW6 |
PhylomeDBi | P0ADW6 |
Enzyme and pathway databases
BioCyci | EcoCyc:G7669-MONOMER |
Miscellaneous databases
PROi | PR:P0ADW6 |
Family and domain databases
Gene3Di | 3.80.30.20, 1 hit |
InterProi | View protein in InterPro IPR039661, ELP3 IPR006638, Elp3/MiaB/NifB IPR032432, Radical_SAM_C IPR007197, rSAM IPR023404, rSAM_horseshoe IPR005911, YhcC-like |
PANTHERi | PTHR11135, PTHR11135, 1 hit PTHR11135:SF1, PTHR11135:SF1, 1 hit |
Pfami | View protein in Pfam PF04055, Radical_SAM, 1 hit PF16199, Radical_SAM_C, 1 hit |
SFLDi | SFLDS00029, Radical_SAM, 1 hit SFLDG01091, uncharacterized_CHP01210-like, 1 hit |
SMARTi | View protein in SMART SM00729, Elp3, 1 hit |
TIGRFAMsi | TIGR01212, TIGR01212, 1 hit |
PROSITEi | View protein in PROSITE PS51918, RADICAL_SAM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | YHCC_ECOLI | |
Accessioni | P0ADW6Primary (citable) accession number: P0ADW6 Secondary accession number(s): P45476, Q2M901 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2005 |
Last sequence update: | December 6, 2005 | |
Last modified: | December 2, 2020 | |
This is version 111 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families