Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lipopolysaccharide export system protein LptC

Gene

lptC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA.UniRule annotation5 Publications

Miscellaneous

Interacts with the LptBFG ABC transporter complex, but does not affect its ATPase activity.1 Publication

GO - Molecular functioni

  • glycolipid transporter activity Source: EcoCyc
  • identical protein binding Source: IntAct
  • lipopolysaccharide transmembrane transporter activity Source: InterPro

GO - Biological processi

  • lipopolysaccharide transport Source: EcoCyc

Enzyme and pathway databases

BioCyciEcoCyc:G7664-MONOMER
MetaCyc:G7664-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Lipopolysaccharide export system protein LptCUniRule annotation
Gene namesi
Name:lptCUniRule annotation
Synonyms:yrbK
Ordered Locus Names:b3199, JW3166
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12806 lptC

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 25HelicalUniRule annotationAdd BLAST19

GO - Cellular componenti

  • integral component of membrane Source: EcoCyc
  • integral component of plasma membrane Source: EcoCyc
  • outer membrane-bounded periplasmic space Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Leads to irreversible cell damage, growth arrest and an extreme sensitivity to SDS.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi56G → V: Impairs LPS transport. Does not abolish interaction with LptA. 1 Publication1
Mutagenesisi153G → R: Impairs LPS transport. Fails to interacts with LptA. 1 Publication1
Mutagenesisi177 – 191Missing : Fails to interact with LptA. 1 PublicationAdd BLAST15

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001694701 – 191Lipopolysaccharide export system protein LptCAdd BLAST191

Proteomic databases

PaxDbiP0ADV9
PRIDEiP0ADV9

Interactioni

Subunit structurei

Component of the lipopolysaccharide transport and assembly complex. Interacts with LptA and the LptBFG transporter complex. When overexpressed, can form homodimers in vivo.UniRule annotation5 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi4259279, 274 interactors
DIPiDIP-12912N
IntActiP0ADV9, 3 interactors
MINTiP0ADV9
STRINGi316385.ECDH10B_3373

Structurei

Secondary structure

1191
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi60 – 63Combined sources4
Beta strandi65 – 70Combined sources6
Turni71 – 74Combined sources4
Beta strandi75 – 80Combined sources6
Beta strandi82 – 86Combined sources5
Beta strandi92 – 97Combined sources6
Beta strandi99 – 103Combined sources5
Beta strandi107 – 119Combined sources13
Beta strandi121 – 123Combined sources3
Beta strandi125 – 137Combined sources13
Turni138 – 140Combined sources3
Beta strandi142 – 155Combined sources14
Beta strandi157 – 166Combined sources10
Turni167 – 170Combined sources4
Beta strandi171 – 180Combined sources10

3D structure databases

ProteinModelPortaliP0ADV9
SMRiP0ADV9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0ADV9

Family & Domainsi

Sequence similaritiesi

Belongs to the LptC family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108P1K Bacteria
COG3117 LUCA
HOGENOMiHOG000125239
KOiK11719
OMAiYWQVQSK

Family and domain databases

HAMAPiMF_01915 LPS_assembly_LptC, 1 hit
InterProiView protein in InterPro
IPR010664 LipoPS_assembly_LptC-rel
IPR026265 LptC
PfamiView protein in Pfam
PF06835 LptC, 1 hit
PIRSFiPIRSF028513 LptC, 1 hit
TIGRFAMsiTIGR04409 LptC_YrbK, 1 hit

Sequencei

Sequence statusi: Complete.

P0ADV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKARRWVII VLSLAVLVMI GINMAEKDDT AQVVVNNNDP TYKSEHTDTL
60 70 80 90 100
VYNPEGALSY RLIAQHVEYY SDQAVSWFTQ PVLTTFDKDK IPTWSVKADK
110 120 130 140 150
AKLTNDRMLY LYGHVEVNAL VPDSQLRRIT TDNAQINLVT QDVTSEDLVT
160 170 180 190
LYGTTFNSSG LKMRGNLRSK NAELIEKVRT SYEIQNKQTQ P
Length:191
Mass (Da):21,703
Last modified:December 6, 2005 - v1
Checksum:iF6BAE79EA232CD95
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2S → G AA sequence (PubMed:19500581).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA Translation: AAA58001.1
U00096 Genomic DNA Translation: AAC76231.1
AP009048 Genomic DNA Translation: BAE77243.1
U12684 Genomic DNA No translation available.
PIRiA65111
RefSeqiNP_417666.1, NC_000913.3
WP_000030537.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76231; AAC76231; b3199
BAE77243; BAE77243; BAE77243
GeneIDi947722
KEGGiecj:JW3166
eco:b3199
PATRICifig|1411691.4.peg.3532

Similar proteinsi

Entry informationi

Entry nameiLPTC_ECOLI
AccessioniPrimary (citable) accession number: P0ADV9
Secondary accession number(s): P45397, Q2M913
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: March 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health