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Protein

Cell division protein ZapA

Gene

zapA

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.UniRule annotation

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Septation

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein ZapAUniRule annotation
Alternative name(s):
Z ring-associated protein ZapAUniRule annotation
Gene namesi
Name:zapAUniRule annotation
Ordered Locus Names:Z4247, ECs3781
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001693511 – 109Cell division protein ZapAAdd BLAST109

Interactioni

Subunit structurei

Homodimer. Interacts with FtsZ.UniRule annotation

Protein-protein interaction databases

STRINGi155864.Z4247

Structurei

3D structure databases

ProteinModelPortaliP0ADS4
SMRiP0ADS4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili21 – 99UniRule annotationAdd BLAST79

Sequence similaritiesi

Belongs to the ZapA family. Type 1 subfamily.UniRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG4107YUN Bacteria
COG3027 LUCA
HOGENOMiHOG000263522
KOiK09888
OMAiNICYELH

Family and domain databases

HAMAPiMF_02012 ZapA_type1, 1 hit
InterProiView protein in InterPro
IPR007838 Cell_div_ZapA-like
IPR036192 Cell_div_ZapA-like_sf
IPR023771 Cell_div_ZapA_eubact
PANTHERiPTHR34981 PTHR34981, 1 hit
PfamiView protein in Pfam
PF05164 ZapA, 1 hit
SUPFAMiSSF102829 SSF102829, 1 hit

Sequencei

Sequence statusi: Complete.

P0ADS4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAQPVDIQI FGRSLRVNCP PDQRDALNQA ADDLNQRLQD LKERTRVTNT
60 70 80 90 100
EQLVFIAALN ISYELAQEKA KTRDYAASME QRIRMLQQTI EQALLEQGRI

TEKTNQNFE
Length:109
Mass (Da):12,594
Last modified:December 6, 2005 - v1
Checksum:i26777CC2B2B71148
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG58037.1
BA000007 Genomic DNA Translation: BAB37204.1
PIRiA85947
E91101
RefSeqiNP_311808.1, NC_002695.1
WP_001276008.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG58037; AAG58037; Z4247
BAB37204; BAB37204; BAB37204
GeneIDi916400
KEGGiece:Z4247
ecs:ECs3781
PATRICifig|386585.9.peg.3946

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG58037.1
BA000007 Genomic DNA Translation: BAB37204.1
PIRiA85947
E91101
RefSeqiNP_311808.1, NC_002695.1
WP_001276008.1, NZ_NOKN01000002.1

3D structure databases

ProteinModelPortaliP0ADS4
SMRiP0ADS4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi155864.Z4247

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG58037; AAG58037; Z4247
BAB37204; BAB37204; BAB37204
GeneIDi916400
KEGGiece:Z4247
ecs:ECs3781
PATRICifig|386585.9.peg.3946

Phylogenomic databases

eggNOGiENOG4107YUN Bacteria
COG3027 LUCA
HOGENOMiHOG000263522
KOiK09888
OMAiNICYELH

Family and domain databases

HAMAPiMF_02012 ZapA_type1, 1 hit
InterProiView protein in InterPro
IPR007838 Cell_div_ZapA-like
IPR036192 Cell_div_ZapA-like_sf
IPR023771 Cell_div_ZapA_eubact
PANTHERiPTHR34981 PTHR34981, 1 hit
PfamiView protein in Pfam
PF05164 ZapA, 1 hit
SUPFAMiSSF102829 SSF102829, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZAPA_ECO57
AccessioniPrimary (citable) accession number: P0ADS4
Secondary accession number(s): P45580
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: July 18, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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