UniProtKB - P0ADS2 (ZAPA_ECOLI)
Protein
Cell division protein ZapA
Gene
zapA
Organism
Escherichia coli (strain K12)
Status
Functioni
Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.1 Publication
GO - Molecular functioni
- identical protein binding Source: EcoCyc
GO - Biological processi
- cell division Source: EcoliWiki
- division septum assembly Source: EcoliWiki
- FtsZ-dependent cytokinesis Source: EcoCyc
- septin ring assembly Source: EcoliWiki
Keywordsi
Biological process | Cell cycle, Cell division, Septation |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12878-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Cell division protein ZapAAlternative name(s): Z ring-associated protein ZapA |
Gene namesi | Name:zapA Synonyms:ygfE Ordered Locus Names:b2910, JW2878 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm 1 Publication Note: Localizes at mid-cell.
GO - Cellular componenti
- cell division site Source: EcoliWiki
- cell septum Source: EcoliWiki
- cytosol Source: EcoCyc
- plasma membrane Source: UniProtKB-UniRule
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000169350 | 1 – 109 | Cell division protein ZapAAdd BLAST | 109 |
Proteomic databases
jPOSTi | P0ADS2 |
PaxDbi | P0ADS2 |
PRIDEi | P0ADS2 |
Interactioni
Subunit structurei
Homodimer.
Interacts with FtsZ.
2 PublicationsBinary interactionsi
P0ADS2
With | #Exp. | IntAct |
---|---|---|
zapB [P0AF36] | 4 | EBI-1119901,EBI-1134093 |
GO - Molecular functioni
- identical protein binding Source: EcoCyc
Protein-protein interaction databases
BioGRIDi | 4262169, 355 interactors |
IntActi | P0ADS2, 8 interactors |
STRINGi | 511145.b2910 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0ADS2 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 21 – 99 | Sequence analysisAdd BLAST | 79 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | COG3027, Bacteria |
HOGENOMi | CLU_116623_3_0_6 |
InParanoidi | P0ADS2 |
PhylomeDBi | P0ADS2 |
Family and domain databases
HAMAPi | MF_02012, ZapA_type1, 1 hit |
InterProi | View protein in InterPro IPR007838, Cell_div_ZapA-like IPR036192, Cell_div_ZapA-like_sf IPR023771, Cell_div_ZapA_eubact |
PANTHERi | PTHR34981, PTHR34981, 1 hit |
Pfami | View protein in Pfam PF05164, ZapA, 1 hit |
SUPFAMi | SSF102829, SSF102829, 1 hit |
i Sequence
Sequence statusi: Complete.
P0ADS2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSAQPVDIQI FGRSLRVNCP PDQRDALNQA ADDLNQRLQD LKERTRVTNT
60 70 80 90 100
EQLVFIAALN ISYELAQEKA KTRDYAASME QRIRMLQQTI EQALLEQGRI
TEKTNQNFE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 14 | S → Y (PubMed:1339425).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U28377 Genomic DNA Translation: AAA69078.1 U00096 Genomic DNA Translation: AAC75948.1 AP009048 Genomic DNA Translation: BAE76975.1 D90281 Genomic DNA No translation available. M12965 Genomic DNA No translation available. |
PIRi | F65075 |
RefSeqi | NP_417386.1, NC_000913.3 WP_001276008.1, NZ_STEB01000001.1 |
Genome annotation databases
EnsemblBacteriai | AAC75948; AAC75948; b2910 BAE76975; BAE76975; BAE76975 |
GeneIDi | 52078112 947404 |
KEGGi | ecj:JW2878 eco:b2910 |
PATRICi | fig|1411691.4.peg.3822 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U28377 Genomic DNA Translation: AAA69078.1 U00096 Genomic DNA Translation: AAC75948.1 AP009048 Genomic DNA Translation: BAE76975.1 D90281 Genomic DNA No translation available. M12965 Genomic DNA No translation available. |
PIRi | F65075 |
RefSeqi | NP_417386.1, NC_000913.3 WP_001276008.1, NZ_STEB01000001.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4P1M | X-ray | 1.95 | A/B | 1-109 | [»] | |
SMRi | P0ADS2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4262169, 355 interactors |
IntActi | P0ADS2, 8 interactors |
STRINGi | 511145.b2910 |
Proteomic databases
jPOSTi | P0ADS2 |
PaxDbi | P0ADS2 |
PRIDEi | P0ADS2 |
Genome annotation databases
EnsemblBacteriai | AAC75948; AAC75948; b2910 BAE76975; BAE76975; BAE76975 |
GeneIDi | 52078112 947404 |
KEGGi | ecj:JW2878 eco:b2910 |
PATRICi | fig|1411691.4.peg.3822 |
Organism-specific databases
EchoBASEi | EB2716 |
Phylogenomic databases
eggNOGi | COG3027, Bacteria |
HOGENOMi | CLU_116623_3_0_6 |
InParanoidi | P0ADS2 |
PhylomeDBi | P0ADS2 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12878-MONOMER |
Miscellaneous databases
PROi | PR:P0ADS2 |
Family and domain databases
HAMAPi | MF_02012, ZapA_type1, 1 hit |
InterProi | View protein in InterPro IPR007838, Cell_div_ZapA-like IPR036192, Cell_div_ZapA-like_sf IPR023771, Cell_div_ZapA_eubact |
PANTHERi | PTHR34981, PTHR34981, 1 hit |
Pfami | View protein in Pfam PF05164, ZapA, 1 hit |
SUPFAMi | SSF102829, SSF102829, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZAPA_ECOLI | |
Accessioni | P0ADS2Primary (citable) accession number: P0ADS2 Secondary accession number(s): P45580, Q2M9T1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2005 |
Last sequence update: | December 6, 2005 | |
Last modified: | December 2, 2020 | |
This is version 115 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families