UniProtKB - P0ADQ2 (FABY_ECOLI)
Protein
Probable acyltransferase FabY
Gene
fabY
Organism
Escherichia coli (strain K12)
Status
Functioni
Supports initiation of fatty acid biosynthesis in the absence of FabH.1 Publication
Miscellaneous
Overexpression rescues altered fatty acid profile, growth defect and reduced cell size of the fabH deletion mutant.1 Publication
: fatty acid biosynthesis Pathwayi
This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.1 PublicationView all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.
GO - Molecular functioni
- glucosamine 6-phosphate N-acetyltransferase activity Source: InterPro
- transferase activity, transferring acyl groups other than amino-acyl groups Source: GO_Central
GO - Biological processi
- fatty acid biosynthetic process Source: UniProtKB-UniPathway
- UDP-N-acetylglucosamine biosynthetic process Source: InterPro
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Lipid metabolism |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11853-MONOMER |
UniPathwayi | UPA00094 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:fabY1 Publication Synonyms:yiiD Ordered Locus Names:b3888, JW3859 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Pathology & Biotechi
Disruption phenotypei
Deletion mutant does not exhibit any growth defect. Combined inactivation of FabH and FabY results in growth arrest, possibly due to the loss of fatty acid biosynthesis.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000169679 | 1 – 329 | Probable acyltransferase FabYAdd BLAST | 329 |
Proteomic databases
jPOSTi | P0ADQ2 |
PaxDbi | P0ADQ2 |
PRIDEi | P0ADQ2 |
Expressioni
Inductioni
In the absence of FabH, expression is positively regulated by the stringent response factors (p)ppGpp and DksA.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4261099, 128 interactors |
DIPi | DIP-48207N |
IntActi | P0ADQ2, 10 interactors |
STRINGi | 511145.b3888 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 162 | N-acetyltransferasePROSITE-ProRule annotationAdd BLAST | 145 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0456, Bacteria |
HOGENOMi | CLU_063776_0_0_6 |
Family and domain databases
InterProi | View protein in InterPro IPR016181, Acyl_CoA_acyltransferase IPR000182, GNAT_dom IPR039143, GNPNAT1 IPR029069, HotDog_dom_sf IPR012660, YiiD_C |
PANTHERi | PTHR13355, PTHR13355, 1 hit |
Pfami | View protein in Pfam PF00583, Acetyltransf_1, 1 hit PF09500, YiiD_C, 1 hit |
SUPFAMi | SSF54637, SSF54637, 1 hit SSF55729, SSF55729, 1 hit |
TIGRFAMsi | TIGR02447, yiiD_Cterm, 1 hit |
PROSITEi | View protein in PROSITE PS51186, GNAT, 1 hit |
i Sequence
Sequence statusi: Complete.
P0ADQ2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQLPGLSRE TRESIAMYHL RVPQTEEELE RYYQFRWEML RKPLHQPKGS
60 70 80 90 100
ERDAWDAMAH HQMVVDEQGN LVAVGRLYIN ADNEASIRFM AVHPDVQDKG
110 120 130 140 150
LGTLMAMTLE SVARQEGVKR VTCSAREDAV EFFAKLGFVN QGEITTPTTT
160 170 180 190 200
PIRHFLMIKP VATLDDILHR GDWCAQLQQA WYEHIPLSEK MGVRIQQYTG
210 220 230 240 250
QKFITTMPET GNQNPHHTLF AGSLFSLATL TGWGLIWLML RERHLGGTII
260 270 280 290 300
LADAHIRYSK PISGKPHAVA DLGALSGDLD RLARGRKARV QMQVEIFGDE
310 320
TPGAVFEGTY IVLPAKPFGP YEEGGNEEE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L19201 Genomic DNA Translation: AAB03021.1 U00096 Genomic DNA Translation: AAD13450.1 AP009048 Genomic DNA Translation: BAE77421.1 |
PIRi | S40832 |
RefSeqi | NP_418324.1, NC_000913.3 |
Genome annotation databases
EnsemblBacteriai | AAD13450; AAD13450; b3888 BAE77421; BAE77421; BAE77421 |
GeneIDi | 948387 |
KEGGi | ecj:JW3859 eco:b3888 |
PATRICi | fig|511145.12.peg.4000 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L19201 Genomic DNA Translation: AAB03021.1 U00096 Genomic DNA Translation: AAD13450.1 AP009048 Genomic DNA Translation: BAE77421.1 |
PIRi | S40832 |
RefSeqi | NP_418324.1, NC_000913.3 |
3D structure databases
SMRi | P0ADQ2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4261099, 128 interactors |
DIPi | DIP-48207N |
IntActi | P0ADQ2, 10 interactors |
STRINGi | 511145.b3888 |
Proteomic databases
jPOSTi | P0ADQ2 |
PaxDbi | P0ADQ2 |
PRIDEi | P0ADQ2 |
Genome annotation databases
EnsemblBacteriai | AAD13450; AAD13450; b3888 BAE77421; BAE77421; BAE77421 |
GeneIDi | 948387 |
KEGGi | ecj:JW3859 eco:b3888 |
PATRICi | fig|511145.12.peg.4000 |
Organism-specific databases
EchoBASEi | EB1799 |
Phylogenomic databases
eggNOGi | COG0456, Bacteria |
HOGENOMi | CLU_063776_0_0_6 |
Enzyme and pathway databases
UniPathwayi | UPA00094 |
BioCyci | EcoCyc:EG11853-MONOMER |
Miscellaneous databases
PROi | PR:P0ADQ2 |
Family and domain databases
InterProi | View protein in InterPro IPR016181, Acyl_CoA_acyltransferase IPR000182, GNAT_dom IPR039143, GNPNAT1 IPR029069, HotDog_dom_sf IPR012660, YiiD_C |
PANTHERi | PTHR13355, PTHR13355, 1 hit |
Pfami | View protein in Pfam PF00583, Acetyltransf_1, 1 hit PF09500, YiiD_C, 1 hit |
SUPFAMi | SSF54637, SSF54637, 1 hit SSF55729, SSF55729, 1 hit |
TIGRFAMsi | TIGR02447, yiiD_Cterm, 1 hit |
PROSITEi | View protein in PROSITE PS51186, GNAT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FABY_ECOLI | |
Accessioni | P0ADQ2Primary (citable) accession number: P0ADQ2 Secondary accession number(s): P32148, Q2M8I5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2005 |
Last sequence update: | December 6, 2005 | |
Last modified: | April 7, 2021 | |
This is version 116 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families