UniProtKB - P0ADH5 (FIMB_ECOLI)
Protein
Type 1 fimbriae regulatory protein FimB
Gene
fimB
Organism
Escherichia coli (strain K12)
Status
Functioni
FimB is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, FimA. FimB switches FimA on.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 47 | PROSITE-ProRule annotation | 1 | |
Active sitei | 72 | PROSITE-ProRule annotation | 1 | |
Active sitei | 141 | PROSITE-ProRule annotation | 1 | |
Active sitei | 144 | PROSITE-ProRule annotation | 1 | |
Active sitei | 167 | PROSITE-ProRule annotation | 1 | |
Active sitei | 176 | O-(3'-phospho-DNA)-tyrosine intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- DNA binding Source: InterPro
GO - Biological processi
- cellular response to DNA damage stimulus Source: EcoliWiki
- DNA integration Source: EcoCyc
- DNA recombination Source: EcoCyc
Keywordsi
Biological process | DNA integration, DNA recombination, Fimbrium biogenesis, Transcription, Transcription regulation |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10309-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Type 1 fimbriae regulatory protein FimB |
Gene namesi | Name:fimB Ordered Locus Names:b4312, JW4275 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000197539 | 1 – 200 | Type 1 fimbriae regulatory protein FimBAdd BLAST | 200 |
Proteomic databases
PaxDbi | P0ADH5 |
PRIDEi | P0ADH5 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4259374, 158 interactors |
DIPi | DIP-47842N |
IntActi | P0ADH5, 23 interactors |
STRINGi | 511145.b4312 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 189 | Tyr recombinasePROSITE-ProRule annotationAdd BLAST | 182 |
Sequence similaritiesi
Belongs to the 'phage' integrase family.Curated
Phylogenomic databases
eggNOGi | COG0582, Bacteria |
HOGENOMi | CLU_027562_39_0_6 |
InParanoidi | P0ADH5 |
PhylomeDBi | P0ADH5 |
Family and domain databases
Gene3Di | 1.10.443.10, 1 hit |
InterProi | View protein in InterPro IPR011010, DNA_brk_join_enz IPR013762, Integrase-like_cat_sf IPR002104, Integrase_catalytic |
Pfami | View protein in Pfam PF00589, Phage_integrase, 1 hit |
SUPFAMi | SSF56349, SSF56349, 1 hit |
PROSITEi | View protein in PROSITE PS51898, TYR_RECOMBINASE, 1 hit |
i Sequence
Sequence statusi: Complete.
P0ADH5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKNKADNKKR NFLTHSEIES LLKAANTGPH AARNYCLTLL CFIHGFRASE
60 70 80 90 100
ICRLRISDID LKAKCIYIHR LKKGFSTTHP LLNKEVQALK NWLSIRTSYP
110 120 130 140 150
HAESEWVFLS RKGNPLSRQQ FYHIISTSGG NAGLSLEIHP HMLRHSCGFA
160 170 180 190 200
LANMGIDTRL IQDYLGHRNI RHTVWYTASN AGRFYGIWDR ARGRQRHAVL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 13 | L → V in AAA23779 (PubMed:8121417).Curated | 1 | |
Sequence conflicti | 32 | A → G in AAA23779 (PubMed:8121417).Curated | 1 | |
Sequence conflicti | 85 | E → D in CAA27560 (PubMed:2874022).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X03923 Genomic DNA Translation: CAA27560.1 U14003 Genomic DNA Translation: AAA97208.1 U00096 Genomic DNA Translation: AAC77268.1 AP009048 Genomic DNA Translation: BAE78305.1 L07756 Genomic DNA Translation: AAA23779.1 |
PIRi | S56537, RGECFF |
RefSeqi | NP_418732.1, NC_000913.3 WP_000790583.1, NZ_STEB01000025.1 |
Genome annotation databases
EnsemblBacteriai | AAC77268; AAC77268; b4312 BAE78305; BAE78305; BAE78305 |
GeneIDi | 57730617 948832 |
KEGGi | ecj:JW4275 eco:b4312 |
PATRICi | fig|1411691.4.peg.2380 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X03923 Genomic DNA Translation: CAA27560.1 U14003 Genomic DNA Translation: AAA97208.1 U00096 Genomic DNA Translation: AAC77268.1 AP009048 Genomic DNA Translation: BAE78305.1 L07756 Genomic DNA Translation: AAA23779.1 |
PIRi | S56537, RGECFF |
RefSeqi | NP_418732.1, NC_000913.3 WP_000790583.1, NZ_STEB01000025.1 |
3D structure databases
SMRi | P0ADH5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4259374, 158 interactors |
DIPi | DIP-47842N |
IntActi | P0ADH5, 23 interactors |
STRINGi | 511145.b4312 |
Proteomic databases
PaxDbi | P0ADH5 |
PRIDEi | P0ADH5 |
Genome annotation databases
EnsemblBacteriai | AAC77268; AAC77268; b4312 BAE78305; BAE78305; BAE78305 |
GeneIDi | 57730617 948832 |
KEGGi | ecj:JW4275 eco:b4312 |
PATRICi | fig|1411691.4.peg.2380 |
Organism-specific databases
EchoBASEi | EB0305 |
Phylogenomic databases
eggNOGi | COG0582, Bacteria |
HOGENOMi | CLU_027562_39_0_6 |
InParanoidi | P0ADH5 |
PhylomeDBi | P0ADH5 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10309-MONOMER |
Miscellaneous databases
PROi | PR:P0ADH5 |
Family and domain databases
Gene3Di | 1.10.443.10, 1 hit |
InterProi | View protein in InterPro IPR011010, DNA_brk_join_enz IPR013762, Integrase-like_cat_sf IPR002104, Integrase_catalytic |
Pfami | View protein in Pfam PF00589, Phage_integrase, 1 hit |
SUPFAMi | SSF56349, SSF56349, 1 hit |
PROSITEi | View protein in PROSITE PS51898, TYR_RECOMBINASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FIMB_ECOLI | |
Accessioni | P0ADH5Primary (citable) accession number: P0ADH5 Secondary accession number(s): P04742, Q2M601, Q47219 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 13, 1987 |
Last sequence update: | December 6, 2005 | |
Last modified: | February 10, 2021 | |
This is version 111 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families