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Protein

Type 1 fimbriae regulatory protein FimB

Gene

fimB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

FimB is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, FimA. FimB switches FimA on.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei176O-(3'-phospho-DNA)-tyrosine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
  • DNA integration Source: EcoCyc
  • DNA recombination Source: EcoCyc
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Biological processDNA integration, DNA recombination, Fimbrium biogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:EG10309-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Type 1 fimbriae regulatory protein FimB
Gene namesi
Name:fimB
Ordered Locus Names:b4312, JW4275
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10309 fimB

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001975391 – 200Type 1 fimbriae regulatory protein FimBAdd BLAST200

Proteomic databases

PaxDbiP0ADH5
PRIDEiP0ADH5

Interactioni

Protein-protein interaction databases

BioGridi4259374, 158 interactors
DIPiDIP-47842N
IntActiP0ADH5, 23 interactors
STRINGi316407.85677055

Structurei

3D structure databases

ProteinModelPortaliP0ADH5
SMRiP0ADH5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 'phage' integrase family.Curated

Phylogenomic databases

eggNOGiENOG4108W9T Bacteria
ENOG410YF4U LUCA
HOGENOMiHOG000117333
InParanoidiP0ADH5
KOiK07357
OMAiKRWLAIR
PhylomeDBiP0ADH5

Family and domain databases

Gene3Di1.10.443.10, 1 hit
InterProiView protein in InterPro
IPR011010 DNA_brk_join_enz
IPR013762 Integrase-like_cat_sf
IPR002104 Integrase_catalytic
PfamiView protein in Pfam
PF00589 Phage_integrase, 1 hit
SUPFAMiSSF56349 SSF56349, 1 hit

Sequencei

Sequence statusi: Complete.

P0ADH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNKADNKKR NFLTHSEIES LLKAANTGPH AARNYCLTLL CFIHGFRASE
60 70 80 90 100
ICRLRISDID LKAKCIYIHR LKKGFSTTHP LLNKEVQALK NWLSIRTSYP
110 120 130 140 150
HAESEWVFLS RKGNPLSRQQ FYHIISTSGG NAGLSLEIHP HMLRHSCGFA
160 170 180 190 200
LANMGIDTRL IQDYLGHRNI RHTVWYTASN AGRFYGIWDR ARGRQRHAVL
Length:200
Mass (Da):22,993
Last modified:December 6, 2005 - v1
Checksum:i36BFC656C68837C7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13L → V in AAA23779 (PubMed:8121417).Curated1
Sequence conflicti32A → G in AAA23779 (PubMed:8121417).Curated1
Sequence conflicti85E → D in CAA27560 (PubMed:2874022).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03923 Genomic DNA Translation: CAA27560.1
U14003 Genomic DNA Translation: AAA97208.1
U00096 Genomic DNA Translation: AAC77268.1
AP009048 Genomic DNA Translation: BAE78305.1
L07756 Genomic DNA Translation: AAA23779.1
PIRiS56537 RGECFF
RefSeqiNP_418732.1, NC_000913.3
WP_000790583.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77268; AAC77268; b4312
BAE78305; BAE78305; BAE78305
GeneIDi948832
KEGGiecj:JW4275
eco:b4312
PATRICifig|1411691.4.peg.2380

Similar proteinsi

Entry informationi

Entry nameiFIMB_ECOLI
AccessioniPrimary (citable) accession number: P0ADH5
Secondary accession number(s): P04742, Q2M601, Q47219
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: December 6, 2005
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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