fimB

Functionⁱ

FimB is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, FimA. FimB switches FimA on.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	176	O-(3'-phospho-DNA)-tyrosine intermediateBy similarity		1

GO - Molecular functionⁱ

DNA binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to DNA damage stimulus
Source: EcoliWiki
Inferred from expression patternⁱ
- 11967071
DNA integration
Source: EcoCyc
Inferred from mutant phenotypeⁱ
- 2874022
DNA recombination
Source: EcoCyc
Inferred from mutant phenotypeⁱ
- 8101185
regulation of transcription, DNA-templated Source: UniProtKB-KW
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	DNA integration, DNA recombination, Fimbrium biogenesis, Transcription, Transcription regulation

Biological process

DNA integration, DNA recombination, Fimbrium biogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

BioCycⁱ	EcoCyc:EG10309-MONOMER

BioCycⁱ

EcoCyc:EG10309-MONOMER

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Type 1 fimbriae regulatory protein FimB
Gene namesⁱ	Name:fimB Ordered Locus Names:b4312, JW4275
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG10309 fimB

EcoGeneⁱ

EG10309 fimB

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000197539	1 – 200	Type 1 fimbriae regulatory protein FimBAdd BLAST		200

Proteomic databases

PaxDbⁱ	P0ADH5
PRIDEⁱ	P0ADH5

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	4259374, 158 interactors
Database of interacting proteins More...DIPⁱ	DIP-47842N
IntActⁱ	P0ADH5, 23 interactors
STRINGⁱ	316407.85677055

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P0ADH5
SMRⁱ	P0ADH5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the 'phage' integrase family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG4108W9T Bacteria ENOG410YF4U LUCA
HOGENOMⁱ	HOG000117333
InParanoidⁱ	P0ADH5
KEGG Orthology (KO) More...KOⁱ	K07357
OMAⁱ	KRWLAIR
PhylomeDBⁱ	P0ADH5

Family and domain databases

Gene3Dⁱ	1.10.443.10, 1 hit
InterProⁱ	View protein in InterPro IPR011010 DNA_brk_join_enz IPR013762 Integrase-like_cat_sf IPR002104 Integrase_catalytic
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00589 Phage_integrase, 1 hit
SUPFAMⁱ	SSF56349 SSF56349, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P0ADH5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKNKADNKKR NFLTHSEIES LLKAANTGPH AARNYCLTLL CFIHGFRASE 
        60         70         80         90        100
ICRLRISDID LKAKCIYIHR LKKGFSTTHP LLNKEVQALK NWLSIRTSYP 
       110        120        130        140        150
HAESEWVFLS RKGNPLSRQQ FYHIISTSGG NAGLSLEIHP HMLRHSCGFA 
       160        170        180        190        200
LANMGIDTRL IQDYLGHRNI RHTVWYTASN AGRFYGIWDR ARGRQRHAVL

Length:200

Mass (Da):22,993

Last modified:December 6, 2005 - v1

Checksum:ⁱ36BFC656C68837C7

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	13	L → V in AAA23779 (PubMed:8121417).Curated	1
Sequence conflictⁱ	32	A → G in AAA23779 (PubMed:8121417).Curated	1
Sequence conflictⁱ	85	E → D in CAA27560 (PubMed:2874022).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X03923 Genomic DNA Translation: CAA27560.1 U14003 Genomic DNA Translation: AAA97208.1 U00096 Genomic DNA Translation: AAC77268.1 AP009048 Genomic DNA Translation: BAE78305.1 L07756 Genomic DNA Translation: AAA23779.1
PIRⁱ	S56537 RGECFF
NCBI Reference Sequences More...RefSeqⁱ	NP_418732.1, NC_000913.3 WP_000790583.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC77268; AAC77268; b4312 BAE78305; BAE78305; BAE78305
GeneIDⁱ	948832
KEGGⁱ	ecj:JW4275 eco:b4312
PATRICⁱ	fig\|1411691.4.peg.2380

Protein	Similar proteins		Species	Score	Length
P0ADH5	Type 1 fimbriae regulatory protein FimB		ECO57		200
Integrase family protein		Escherichia coli D6-113.11		200
Type 1 fimbriae regulatory protein FimB		Escherichia coli M8		200
Integrase		ECOLX		200
Phage integrase family protein		Escherichia coli 2-427-07_S4_C3		200
+90

Protein	Similar proteins		Species	Score	Length
P0ADH5	Type 1 fimbriae regulatory protein FimB		ECO57		200
Integrase family protein		Escherichia coli D6-113.11		200
Type 1 fimbriae regulatory protein FimB		Escherichia coli M8		200
Integrase		ECOLX		200
Phage integrase family protein		Escherichia coli 2-427-07_S4_C3		200
+335

Protein	Similar proteins		Species	Score	Length
P0ADH5	Type 1 fimbriae regulatory protein FimB		ECO57		200
Integrase family protein		Escherichia coli D6-113.11		200
Type 1 fimbriae regulatory protein FimB		Escherichia coli M8		200
Integrase		ECOLX		200
Phage integrase family protein		Escherichia coli 2-427-07_S4_C3		200
+767

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X03923 Genomic DNA Translation: CAA27560.1 U14003 Genomic DNA Translation: AAA97208.1 U00096 Genomic DNA Translation: AAC77268.1 AP009048 Genomic DNA Translation: BAE78305.1 L07756 Genomic DNA Translation: AAA23779.1
PIRⁱ	S56537 RGECFF
NCBI Reference Sequences More...RefSeqⁱ	NP_418732.1, NC_000913.3 WP_000790583.1, NZ_LN832404.1

3D structure databases

ProteinModelPortalⁱ	P0ADH5
SMRⁱ	P0ADH5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4259374, 158 interactors
Database of interacting proteins More...DIPⁱ	DIP-47842N
IntActⁱ	P0ADH5, 23 interactors
STRINGⁱ	316407.85677055

Proteomic databases

PaxDbⁱ	P0ADH5
PRIDEⁱ	P0ADH5

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC77268; AAC77268; b4312 BAE78305; BAE78305; BAE78305
GeneIDⁱ	948832
KEGGⁱ	ecj:JW4275 eco:b4312
PATRICⁱ	fig\|1411691.4.peg.2380

Organism-specific databases

EchoBASEⁱ	EB0305
EcoGeneⁱ	EG10309 fimB

Phylogenomic databases

eggNOGⁱ	ENOG4108W9T Bacteria ENOG410YF4U LUCA
HOGENOMⁱ	HOG000117333
InParanoidⁱ	P0ADH5
KEGG Orthology (KO) More...KOⁱ	K07357
OMAⁱ	KRWLAIR
PhylomeDBⁱ	P0ADH5

Enzyme and pathway databases

BioCycⁱ	EcoCyc:EG10309-MONOMER

BioCycⁱ

EcoCyc:EG10309-MONOMER

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P0ADH5

PROⁱ

PR:P0ADH5

Family and domain databases

Gene3Dⁱ	1.10.443.10, 1 hit
InterProⁱ	View protein in InterPro IPR011010 DNA_brk_join_enz IPR013762 Integrase-like_cat_sf IPR002104 Integrase_catalytic
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00589 Phage_integrase, 1 hit
SUPFAMⁱ	SSF56349 SSF56349, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FIMB_ECOLI
Accessionⁱ	P0ADH5Primary (citable) accession number: P0ADH5 Secondary accession number(s): P04742, Q2M601, Q47219
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
	Last sequence update:	December 6, 2005
	Last modified:	March 28, 2018
	This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P0ADH5 (FIMB_ECOLI)

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Type 1 fimbriae regulatory protein FimB

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ