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Protein

Acetolactate synthase isozyme 1 small subunit

Gene

ilvN

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2 pyruvate = 2-acetolactate + CO2.

Pathwayi: L-isoleucine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-isoleucine from 2-oxobutanoate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Acetolactate synthase (ilvI), Acetolactate synthase (ECs4612), Acetolactate synthase (ilvB), Acetolactate synthase (ECs0081), Acetolactate synthase (ECs4702), Acetolactate synthase isozyme 1 small subunit (ilvN), Acetolactate synthase (ilvG)
  2. Ketol-acid reductoisomerase (NADP(+)) (ilvC)
  3. Dihydroxy-acid dehydratase (ilvD)
  4. Branched-chain-amino-acid aminotransferase (ilvE)
This subpathway is part of the pathway L-isoleucine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-isoleucine from 2-oxobutanoate, the pathway L-isoleucine biosynthesis and in Amino-acid biosynthesis.

Pathwayi: L-valine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-valine from pyruvate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Acetolactate synthase (ilvI), Acetolactate synthase (ECs4612), Acetolactate synthase (ilvB), Acetolactate synthase (ECs0081), Acetolactate synthase (ECs4702), Acetolactate synthase isozyme 1 small subunit (ilvN), Acetolactate synthase (ilvG)
  2. Ketol-acid reductoisomerase (NADP(+)) (ilvC)
  3. Dihydroxy-acid dehydratase (ilvD)
  4. Branched-chain-amino-acid aminotransferase (ilvE)
This subpathway is part of the pathway L-valine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-valine from pyruvate, the pathway L-valine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processAmino-acid biosynthesis, Branched-chain amino acid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00047; UER00055
UPA00049; UER00059

Names & Taxonomyi

Protein namesi
Recommended name:
Acetolactate synthase isozyme 1 small subunit (EC:2.2.1.6)
Alternative name(s):
Acetohydroxy-acid synthase I small subunit
Short name:
AHAS-I
Short name:
ALS-I
Gene namesi
Name:ilvN
Ordered Locus Names:Z5164, ECs4611
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001514201 – 96Acetolactate synthase isozyme 1 small subunitAdd BLAST96

Interactioni

Subunit structurei

Dimer of large and small chains.By similarity

Protein-protein interaction databases

STRINGi155864.Z5164

Structurei

3D structure databases

ProteinModelPortaliP0ADG0
SMRiP0ADG0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 83ACTPROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105M71 Bacteria
COG0440 LUCA
HOGENOMiHOG000126293
KOiK01653
OMAiQSHENVI

Family and domain databases

InterProiView protein in InterPro
IPR004789 Acetalactate_synth_ssu
IPR002912 ACT_dom
PANTHERiPTHR30239 PTHR30239, 1 hit
PfamiView protein in Pfam
PF01842 ACT, 1 hit
PROSITEiView protein in PROSITE
PS51671 ACT, 1 hit

Sequencei

Sequence statusi: Complete.

P0ADG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNTTHDNVI LELTVRNHPG VMTHVCGLFA RRAFNVEGIL CLPIQDSDKS
60 70 80 90
HIWLLVNDDQ RLEQMISQID KLEDVVKVQR NQSDPTMFNK IAVFFQ
Length:96
Mass (Da):11,106
Last modified:December 6, 2005 - v1
Checksum:i7F37DD421EDD3802
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG58873.1
BA000007 Genomic DNA Translation: BAB38034.1
PIRiC91205
E86051
RefSeqiNP_312638.1, NC_002695.1
WP_001181706.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG58873; AAG58873; Z5164
BAB38034; BAB38034; BAB38034
GeneIDi915423
KEGGiece:Z5164
ecs:ECs4611
PATRICifig|386585.9.peg.4818

Similar proteinsi

Entry informationi

Entry nameiILVN_ECO57
AccessioniPrimary (citable) accession number: P0ADG0
Secondary accession number(s): P08143
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: December 6, 2005
Last modified: April 25, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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