UniProtKB - P0ADE6 (KBP_ECOLI)
Protein
Potassium binding protein Kbp
Gene
kbp
Organism
Escherichia coli (strain K12)
Status
Functioni
Highly specific potassium binding protein that is required for normal growth in the presence of high levels of external K+. May act as a sensor of cytoplasmic K+ concentration. Binds a single K+ ion, which induces a large conformational change. Can also bind the larger alkali metal ions Rb+ and Cs+, and NH4+ (PubMed:27112601). May be involved in the regulation of peptidoglycan cross-linking (PubMed:25422305).2 Publications
GO - Molecular functioni
- potassium ion binding Source: EcoCyc
GO - Biological processi
- response to potassium ion Source: EcoCyc
Keywordsi
Ligand | Potassium |
Enzyme and pathway databases
BioCyci | EcoCyc:G7395-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium binding protein Kbp1 PublicationShort name: K(+) binding protein KbpCurated |
Gene namesi | Name:kbp1 Publication Synonyms:ygaU, yzzM Ordered Locus Names:b2665, JW2640 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000169832 | 2 – 149 | Potassium binding protein KbpAdd BLAST | 148 |
Proteomic databases
jPOSTi | P0ADE6 |
PaxDbi | P0ADE6 |
PRIDEi | P0ADE6 |
2D gel databases
SWISS-2DPAGEi | P0ADE6 |
Expressioni
Inductioni
Transcriptionally regulated by CpxR, which binds directly to the promoter region.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4262266, 15 interactors |
DIPi | DIP-48134N |
IntActi | P0ADE6, 1 interactor |
STRINGi | 511145.b2665 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0ADE6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 91 | BONPROSITE-ProRule annotationAdd BLAST | 69 | |
Domaini | 97 – 146 | LysMPROSITE-ProRule annotationAdd BLAST | 50 |
Domaini
BON and LysM domains are both required for full K+ binding. The major K+ binding site is located in the BON domain and this initial complex is stabilized by interaction with the LysM domain.1 Publication
Phylogenomic databases
eggNOGi | COG1652, Bacteria |
InParanoidi | P0ADE6 |
PhylomeDBi | P0ADE6 |
Family and domain databases
CDDi | cd00118, LysM, 1 hit |
Gene3Di | 3.10.350.10, 1 hit |
InterProi | View protein in InterPro IPR007055, BON_dom IPR018392, LysM_dom IPR036779, LysM_dom_sf IPR014004, Transpt-assoc_nodulatn_dom_bac |
Pfami | View protein in Pfam PF04972, BON, 1 hit PF01476, LysM, 1 hit |
SMARTi | View protein in SMART SM00749, BON, 1 hit SM00257, LysM, 1 hit |
PROSITEi | View protein in PROSITE PS50914, BON, 1 hit PS51782, LYSM, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P0ADE6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLFNFVKDA GEKLWDAVTG QHDKDDQAKK VQEHLNKTGI PDADKVNIQI
60 70 80 90 100
ADGKATVTGD GLSQEAKEKI LVAVGNISGI ASVDDQVKTA TPATASQFYT
110 120 130 140
VKSGDTLSAI SKQVYGNANL YNKIFEANKP MLKSPDKIYP GQVLRIPEE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC75712.1 AP009048 Genomic DNA Translation: BAA16528.1 |
PIRi | B65046 |
RefSeqi | NP_417151.1, NC_000913.3 WP_000522415.1, NZ_STEB01000042.1 |
Genome annotation databases
EnsemblBacteriai | AAC75712; AAC75712; b2665 BAA16528; BAA16528; BAA16528 |
GeneIDi | 58461817 947144 |
KEGGi | ecj:JW2640 eco:b2665 |
PATRICi | fig|511145.12.peg.2757 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC75712.1 AP009048 Genomic DNA Translation: BAA16528.1 |
PIRi | B65046 |
RefSeqi | NP_417151.1, NC_000913.3 WP_000522415.1, NZ_STEB01000042.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5FIM | NMR | - | A | 1-149 | [»] | |
SMRi | P0ADE6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4262266, 15 interactors |
DIPi | DIP-48134N |
IntActi | P0ADE6, 1 interactor |
STRINGi | 511145.b2665 |
2D gel databases
SWISS-2DPAGEi | P0ADE6 |
Proteomic databases
jPOSTi | P0ADE6 |
PaxDbi | P0ADE6 |
PRIDEi | P0ADE6 |
Genome annotation databases
EnsemblBacteriai | AAC75712; AAC75712; b2665 BAA16528; BAA16528; BAA16528 |
GeneIDi | 58461817 947144 |
KEGGi | ecj:JW2640 eco:b2665 |
PATRICi | fig|511145.12.peg.2757 |
Organism-specific databases
EchoBASEi | EB2540 |
Phylogenomic databases
eggNOGi | COG1652, Bacteria |
InParanoidi | P0ADE6 |
PhylomeDBi | P0ADE6 |
Enzyme and pathway databases
BioCyci | EcoCyc:G7395-MONOMER |
Miscellaneous databases
PROi | PR:P0ADE6 |
Family and domain databases
CDDi | cd00118, LysM, 1 hit |
Gene3Di | 3.10.350.10, 1 hit |
InterProi | View protein in InterPro IPR007055, BON_dom IPR018392, LysM_dom IPR036779, LysM_dom_sf IPR014004, Transpt-assoc_nodulatn_dom_bac |
Pfami | View protein in Pfam PF04972, BON, 1 hit PF01476, LysM, 1 hit |
SMARTi | View protein in SMART SM00749, BON, 1 hit SM00257, LysM, 1 hit |
PROSITEi | View protein in PROSITE PS50914, BON, 1 hit PS51782, LYSM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KBP_ECOLI | |
Accessioni | P0ADE6Primary (citable) accession number: P0ADE6 Secondary accession number(s): P39169 P77023 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2005 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 106 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references