UniProtKB - P0ADC3 (LOLC_ECOLI)
Protein
Lipoprotein-releasing system transmembrane protein LolC
Gene
lolC
Organism
Escherichia coli (strain K12)
Status
Functioni
Part of an ATP-dependent transport system LolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA.
GO - Molecular functioni
- lipoprotein releasing activity Source: EcoCyc
GO - Biological processi
- lipoprotein localization to outer membrane Source: EcoCyc
- lipoprotein transport Source: InterPro
- protein localization to outer membrane Source: CACAO
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:YCFU-MONOMER |
Protein family/group databases
TCDBi | 3.A.1.125.1, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Lipoprotein-releasing system transmembrane protein LolC |
Gene namesi | Name:lolC Synonyms:ycfU Ordered Locus Names:b1116, JW5161 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: EcoCyc
- plasma membrane Source: EcoCyc
- plasma membrane protein complex Source: EcoCyc
Other locations
- outer membrane-bounded periplasmic space Source: EcoCyc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 25 – 45 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 270 – 290 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 310 – 330 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 358 – 378 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000201810 | 1 – 399 | Lipoprotein-releasing system transmembrane protein LolCAdd BLAST | 399 |
Proteomic databases
jPOSTi | P0ADC3 |
PaxDbi | P0ADC3 |
PRIDEi | P0ADC3 |
Interactioni
Binary interactionsi
P0ADC3
With | #Exp. | IntAct |
---|---|---|
lolA [P61316] | 2 | EBI-15765497,EBI-553532 |
Protein-protein interaction databases
BioGRIDi | 4261911, 381 interactors |
ComplexPortali | CPX-4262, LolCDE lipoprotein ABC transporter complex |
DIPi | DIP-58651N |
IntActi | P0ADC3, 2 interactors |
STRINGi | 511145.b1116 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0ADC3 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG4591, Bacteria |
HOGENOMi | CLU_000604_8_1_6 |
InParanoidi | P0ADC3 |
PhylomeDBi | P0ADC3 |
Family and domain databases
InterProi | View protein in InterPro IPR003838, ABC3_permease_dom IPR011925, LolCE_TM IPR025857, MacB_PCD |
Pfami | View protein in Pfam PF02687, FtsX, 1 hit PF12704, MacB_PCD, 1 hit |
TIGRFAMsi | TIGR02212, lolCE, 1 hit |
i Sequence
Sequence statusi: Complete.
P0ADC3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYQPVALFIG LRYMRGRAAD RFGRFVSWLS TIGITLGVMA LVTVLSVMNG
60 70 80 90 100
FERELQNNIL GLMPQAILSS EHGSLNPQQL PETAVKLDGV NRVAPITTGD
110 120 130 140 150
VVLQSARSVA VGVMLGIDPA QKDPLTPYLV NVKQTDLEPG KYNVILGEQL
160 170 180 190 200
ASQLGVNRGD QIRVMVPSAS QFTPMGRIPS QRLFNVIGTF AANSEVDGYE
210 220 230 240 250
MLVNIEDASR LMRYPAGNIT GWRLWLDEPL KVDSLSQQKL PEGSKWQDWR
260 270 280 290 300
DRKGELFQAV RMEKNMMGLL LSLIVAVAAF NIITSLGLMV MEKQGEVAIL
310 320 330 340 350
QTQGLTPRQI MMVFMVQGAS AGIIGAILGA ALGALLASQL NNLMPIIGVL
360 370 380 390
LDGAALPVAI EPLQVIVIAL VAMAIALLST LYPSWRAAAT QPAEALRYE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74200.1 AP009048 Genomic DNA Translation: BAA35936.2 |
PIRi | A64856 |
RefSeqi | NP_415634.1, NC_000913.3 WP_000284714.1, NZ_STEB01000016.1 |
Genome annotation databases
EnsemblBacteriai | AAC74200; AAC74200; b1116 BAA35936; BAA35936; BAA35936 |
GeneIDi | 57731902 945673 |
KEGGi | ecj:JW5161 eco:b1116 |
PATRICi | fig|1411691.4.peg.1151 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74200.1 AP009048 Genomic DNA Translation: BAA35936.2 |
PIRi | A64856 |
RefSeqi | NP_415634.1, NC_000913.3 WP_000284714.1, NZ_STEB01000016.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5NAA | X-ray | 1.88 | A/B | 48-266 | [»] | |
6F3Z | X-ray | 2.00 | A/C | 48-266 | [»] | |
6F49 | X-ray | 2.02 | A/B/C/D | 48-166 | [»] | |
A/B/C/D | 180-266 | [»] | ||||
SMRi | P0ADC3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4261911, 381 interactors |
ComplexPortali | CPX-4262, LolCDE lipoprotein ABC transporter complex |
DIPi | DIP-58651N |
IntActi | P0ADC3, 2 interactors |
STRINGi | 511145.b1116 |
Protein family/group databases
TCDBi | 3.A.1.125.1, the atp-binding cassette (abc) superfamily |
Proteomic databases
jPOSTi | P0ADC3 |
PaxDbi | P0ADC3 |
PRIDEi | P0ADC3 |
Genome annotation databases
EnsemblBacteriai | AAC74200; AAC74200; b1116 BAA35936; BAA35936; BAA35936 |
GeneIDi | 57731902 945673 |
KEGGi | ecj:JW5161 eco:b1116 |
PATRICi | fig|1411691.4.peg.1151 |
Organism-specific databases
EchoBASEi | EB3213 |
Phylogenomic databases
eggNOGi | COG4591, Bacteria |
HOGENOMi | CLU_000604_8_1_6 |
InParanoidi | P0ADC3 |
PhylomeDBi | P0ADC3 |
Enzyme and pathway databases
BioCyci | EcoCyc:YCFU-MONOMER |
Miscellaneous databases
PROi | PR:P0ADC3 |
Family and domain databases
InterProi | View protein in InterPro IPR003838, ABC3_permease_dom IPR011925, LolCE_TM IPR025857, MacB_PCD |
Pfami | View protein in Pfam PF02687, FtsX, 1 hit PF12704, MacB_PCD, 1 hit |
TIGRFAMsi | TIGR02212, lolCE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LOLC_ECOLI | |
Accessioni | P0ADC3Primary (citable) accession number: P0ADC3 Secondary accession number(s): P75956, Q9R7N7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2005 |
Last sequence update: | December 6, 2005 | |
Last modified: | April 7, 2021 | |
This is version 118 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families