Branched-chain amino acid transport system 2 carrier protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• L-isoleucine transmembrane transporter activity Source: EcoCyc <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Mutations affecting the different transport systems for isoleucine, leucine, and valine in Escherichia coli K-12."
    Guardiola J., De Felice M., Klopotowski T., Iaccarino M.
    J Bacteriol 117:393-405(1974) [PubMed] [Europe PMC] [Abstract]
  • "Escherichia coli K-12 mutants altered in the transport of branched-chain amino acids."
    Guardiola J., Iaccarino M.
    J Bacteriol 108:1034-1044(1971) [PubMed] [Europe PMC] [Abstract]
• L-leucine transmembrane transporter activity Source: EcoCycInferred from mutant phenotypeⁱ
  • "Mutations affecting the different transport systems for isoleucine, leucine, and valine in Escherichia coli K-12."
    Guardiola J., De Felice M., Klopotowski T., Iaccarino M.
    J Bacteriol 117:393-405(1974) [PubMed] [Europe PMC] [Abstract]
  • "Escherichia coli K-12 mutants altered in the transport of branched-chain amino acids."
    Guardiola J., Iaccarino M.
    J Bacteriol 108:1034-1044(1971) [PubMed] [Europe PMC] [Abstract]
• L-valine transmembrane transporter activity Source: EcoCycInferred from mutant phenotypeⁱ
  • "Mutations affecting the different transport systems for isoleucine, leucine, and valine in Escherichia coli K-12."
    Guardiola J., De Felice M., Klopotowski T., Iaccarino M.
    J Bacteriol 117:393-405(1974) [PubMed] [Europe PMC] [Abstract]
  • "Escherichia coli K-12 mutants altered in the transport of branched-chain amino acids."
    Guardiola J., Iaccarino M.
    J Bacteriol 108:1034-1044(1971) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• branched-chain amino acid transport Source: EcoliWikiInferred from mutant phenotypeⁱ
  • "Mutations affecting the different transport systems for isoleucine, leucine, and valine in Escherichia coli K-12."
    Guardiola J., De Felice M., Klopotowski T., Iaccarino M.
    J Bacteriol 117:393-405(1974) [PubMed] [Europe PMC] [Abstract]
• isoleucine transport Source: EcoliWikiInferred from mutant phenotypeⁱ
  • "Mutations affecting the different transport systems for isoleucine, leucine, and valine in Escherichia coli K-12."
    Guardiola J., De Felice M., Klopotowski T., Iaccarino M.
    J Bacteriol 117:393-405(1974) [PubMed] [Europe PMC] [Abstract]
• leucine transport Source: EcoliWikiInferred from mutant phenotypeⁱ
  • "Mutations affecting the different transport systems for isoleucine, leucine, and valine in Escherichia coli K-12."
    Guardiola J., De Felice M., Klopotowski T., Iaccarino M.
    J Bacteriol 117:393-405(1974) [PubMed] [Europe PMC] [Abstract]
• valine transport Source: EcoliWikiInferred from mutant phenotypeⁱ
  • "Mutations affecting the different transport systems for isoleucine, leucine, and valine in Escherichia coli K-12."
    Guardiola J., De Felice M., Klopotowski T., Iaccarino M.
    J Bacteriol 117:393-405(1974) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

GO - Cellular componentⁱ

• integral component of membrane Source: UniProtKB-KW
• plasma membrane Source: EcoCyc <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.6

    "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
  • "Genetic and biochemical studies of transport systems for branched-chain amino acids in Escherichia coli."
    Yamato I., Ohki M., Anraku Y.
    J Bacteriol 138:24-32(1979) [PubMed] [Europe PMC] [Abstract]

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MTHQLRSRDI IALGFMTFAL FVGAGNIIFP PMVGLQAGEH VWTAAFGFLI 
        60         70         80         90        100
TAVGLPVLTV VALAKVGGGV DSLSTPIGKV AGVLLATVCY LAVGPLFATP 
       110        120        130        140        150
RTATVSFEVG IAPLTGDSAL PLFIYSLVYF AIVILVSLYP GKLLDTVGNF 
       160        170        180        190        200
LAPLKIIALV ILSVAAIVWP AGSISTATEA YQNAAFSNGF VNGYLTMDTL 
       210        220        230        240        250
GAMVFGIVIV NAARSRGVTE ARLLTRYTVW AGLMAGVGLT LLYLALFRLG 
       260        270        280        290        300
SDSASLVDQS ANGAAILHAY VQHTFGGGGS FLLAALIFIA CLVTAVGLTC 
       310        320        330        340        350
ACAEFFAQYV PLSYRTLVFI LGGFSMVVSN LGLSQLIQIS VPVLTAIYPP 
       360        370        380        390        400
CIALVVLSFT RSWWHNSSRV IAPPMFISLL FGILDGIKAS AFSDILPSWA 
       410        420        430 
QRLPLAEQGL AWLMPTVVMV VLAIIWDRAA GRQVTSSAH             

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families