UniProtKB - P0AD99 (BRNQ_ECOLI)
Protein
Branched-chain amino acid transport system 2 carrier protein
Gene
brnQ
Organism
Escherichia coli (strain K12)
Status
Functioni
Component of the LIV-II transport system for branched-chain amino acids. This LIV-II transport system may be H+-coupled.
GO - Molecular functioni
- L-isoleucine transmembrane transporter activity Source: EcoCyc
- L-leucine transmembrane transporter activity Source: EcoCyc
- L-valine transmembrane transporter activity Source: EcoCyc
GO - Biological processi
- branched-chain amino acid transport Source: EcoliWiki
- isoleucine transport Source: EcoliWiki
- leucine transport Source: EcoliWiki
- valine transport Source: EcoliWiki
Keywordsi
Biological process | Amino-acid transport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:BRNQ-MONOMER MetaCyc:BRNQ-MONOMER |
Protein family/group databases
TCDBi | 2.A.26.1.10, the branched chain amino acid:cation symporter (livcs) family |
Names & Taxonomyi
Protein namesi | Recommended name: Branched-chain amino acid transport system 2 carrier proteinAlternative name(s): LIV-II |
Gene namesi | Name:brnQ Ordered Locus Names:b0401, JW0391 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 9 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 10 – 30 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 31 – 45 | PeriplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 46 – 66 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 67 – 79 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 80 – 100 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 101 – 118 | PeriplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 119 – 139 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 140 – 149 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 150 – 170 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 171 – 189 | PeriplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 190 – 210 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 211 – 226 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 227 – 247 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 248 – 277 | PeriplasmicSequence analysisAdd BLAST | 30 | |
Transmembranei | 278 – 298 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 299 – 316 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 317 – 337 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 338 | PeriplasmicSequence analysis | 1 | |
Transmembranei | 339 – 359 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 360 – 369 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 370 – 390 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 391 – 404 | PeriplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 405 – 425 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 426 – 439 | CytoplasmicSequence analysisAdd BLAST | 14 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000099765 | 1 – 439 | Branched-chain amino acid transport system 2 carrier proteinAdd BLAST | 439 |
Proteomic databases
PaxDbi | P0AD99 |
PRIDEi | P0AD99 |
Interactioni
Binary interactionsi
P0AD99
With | #Exp. | IntAct |
---|---|---|
pheS [P08312] | 5 | EBI-555687,EBI-555676 |
Protein-protein interaction databases
BioGRIDi | 4259819, 39 interactors 849431, 1 interactor |
DIPi | DIP-48078N |
IntActi | P0AD99, 1 interactor |
STRINGi | 511145.b0401 |
Family & Domainsi
Sequence similaritiesi
Belongs to the branched chain amino acid transporter family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG1114, Bacteria |
HOGENOMi | CLU_036807_0_0_6 |
InParanoidi | P0AD99 |
PhylomeDBi | P0AD99 |
Family and domain databases
InterProi | View protein in InterPro IPR004685, Brnchd-chn_aa_trnsp_Livcs |
PANTHERi | PTHR30588, PTHR30588, 1 hit |
Pfami | View protein in Pfam PF05525, Branch_AA_trans, 1 hit |
TIGRFAMsi | TIGR00796, livcs, 1 hit |
i Sequence
Sequence statusi: Complete.
P0AD99-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTHQLRSRDI IALGFMTFAL FVGAGNIIFP PMVGLQAGEH VWTAAFGFLI
60 70 80 90 100
TAVGLPVLTV VALAKVGGGV DSLSTPIGKV AGVLLATVCY LAVGPLFATP
110 120 130 140 150
RTATVSFEVG IAPLTGDSAL PLFIYSLVYF AIVILVSLYP GKLLDTVGNF
160 170 180 190 200
LAPLKIIALV ILSVAAIVWP AGSISTATEA YQNAAFSNGF VNGYLTMDTL
210 220 230 240 250
GAMVFGIVIV NAARSRGVTE ARLLTRYTVW AGLMAGVGLT LLYLALFRLG
260 270 280 290 300
SDSASLVDQS ANGAAILHAY VQHTFGGGGS FLLAALIFIA CLVTAVGLTC
310 320 330 340 350
ACAEFFAQYV PLSYRTLVFI LGGFSMVVSN LGLSQLIQIS VPVLTAIYPP
360 370 380 390 400
CIALVVLSFT RSWWHNSSRV IAPPMFISLL FGILDGIKAS AFSDILPSWA
410 420 430
QRLPLAEQGL AWLMPTVVMV VLAIIWDRAA GRQVTSSAH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U73857 Genomic DNA Translation: AAB18125.1 U82664 Genomic DNA Translation: AAB40157.1 U00096 Genomic DNA Translation: AAC73504.1 AP009048 Genomic DNA Translation: BAE76181.1 X04704 Genomic DNA No translation available. |
PIRi | A64769 |
RefSeqi | NP_414935.1, NC_000913.3 WP_000149639.1, NZ_SSZK01000009.1 |
Genome annotation databases
EnsemblBacteriai | AAC73504; AAC73504; b0401 BAE76181; BAE76181; BAE76181 |
GeneIDi | 52075740 945042 |
KEGGi | ecj:JW0391 eco:b0401 |
PATRICi | fig|1411691.4.peg.1876 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U73857 Genomic DNA Translation: AAB18125.1 U82664 Genomic DNA Translation: AAB40157.1 U00096 Genomic DNA Translation: AAC73504.1 AP009048 Genomic DNA Translation: BAE76181.1 X04704 Genomic DNA No translation available. |
PIRi | A64769 |
RefSeqi | NP_414935.1, NC_000913.3 WP_000149639.1, NZ_SSZK01000009.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4259819, 39 interactors 849431, 1 interactor |
DIPi | DIP-48078N |
IntActi | P0AD99, 1 interactor |
STRINGi | 511145.b0401 |
Protein family/group databases
TCDBi | 2.A.26.1.10, the branched chain amino acid:cation symporter (livcs) family |
Proteomic databases
PaxDbi | P0AD99 |
PRIDEi | P0AD99 |
Genome annotation databases
EnsemblBacteriai | AAC73504; AAC73504; b0401 BAE76181; BAE76181; BAE76181 |
GeneIDi | 52075740 945042 |
KEGGi | ecj:JW0391 eco:b0401 |
PATRICi | fig|1411691.4.peg.1876 |
Organism-specific databases
EchoBASEi | EB2087 |
Phylogenomic databases
eggNOGi | COG1114, Bacteria |
HOGENOMi | CLU_036807_0_0_6 |
InParanoidi | P0AD99 |
PhylomeDBi | P0AD99 |
Enzyme and pathway databases
BioCyci | EcoCyc:BRNQ-MONOMER MetaCyc:BRNQ-MONOMER |
Miscellaneous databases
PROi | PR:P0AD99 |
Family and domain databases
InterProi | View protein in InterPro IPR004685, Brnchd-chn_aa_trnsp_Livcs |
PANTHERi | PTHR30588, PTHR30588, 1 hit |
Pfami | View protein in Pfam PF05525, Branch_AA_trans, 1 hit |
TIGRFAMsi | TIGR00796, livcs, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BRNQ_ECOLI | |
Accessioni | P0AD99Primary (citable) accession number: P0AD99 Secondary accession number(s): P37011 Q2MC25 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2005 |
Last sequence update: | December 6, 2005 | |
Last modified: | December 2, 2020 | |
This is version 113 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families