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Entry version 114 (10 Feb 2021)
Sequence version 1 (06 Dec 2005)
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Protein

Branched-chain amino acid transport system 2 carrier protein

Gene

brnQ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the LIV-II transport system for branched-chain amino acids. This LIV-II transport system may be H+-coupled.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:BRNQ-MONOMER
MetaCyc:BRNQ-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.26.1.10, the branched chain amino acid:cation symporter (livcs) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Branched-chain amino acid transport system 2 carrier protein
Alternative name(s):
LIV-II
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:brnQ
Ordered Locus Names:b0401, JW0391
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 9CytoplasmicSequence analysis9
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 45PeriplasmicSequence analysisAdd BLAST15
Transmembranei46 – 66HelicalSequence analysisAdd BLAST21
Topological domaini67 – 79CytoplasmicSequence analysisAdd BLAST13
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Topological domaini101 – 118PeriplasmicSequence analysisAdd BLAST18
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 149CytoplasmicSequence analysis10
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Topological domaini171 – 189PeriplasmicSequence analysisAdd BLAST19
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 226CytoplasmicSequence analysisAdd BLAST16
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Topological domaini248 – 277PeriplasmicSequence analysisAdd BLAST30
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Topological domaini299 – 316CytoplasmicSequence analysisAdd BLAST18
Transmembranei317 – 337HelicalSequence analysisAdd BLAST21
Topological domaini338PeriplasmicSequence analysis1
Transmembranei339 – 359HelicalSequence analysisAdd BLAST21
Topological domaini360 – 369CytoplasmicSequence analysis10
Transmembranei370 – 390HelicalSequence analysisAdd BLAST21
Topological domaini391 – 404PeriplasmicSequence analysisAdd BLAST14
Transmembranei405 – 425HelicalSequence analysisAdd BLAST21
Topological domaini426 – 439CytoplasmicSequence analysisAdd BLAST14

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000997651 – 439Branched-chain amino acid transport system 2 carrier proteinAdd BLAST439

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0AD99

PRoteomics IDEntifications database

More...
PRIDEi
P0AD99

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4259819, 39 interactors
849431, 1 interactor

Database of interacting proteins

More...
DIPi
DIP-48078N

Protein interaction database and analysis system

More...
IntActi
P0AD99, 1 interactor

STRING: functional protein association networks

More...
STRINGi
511145.b0401

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1114, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_036807_0_0_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0AD99

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0AD99

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004685, Brnchd-chn_aa_trnsp_Livcs

The PANTHER Classification System

More...
PANTHERi
PTHR30588, PTHR30588, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05525, Branch_AA_trans, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00796, livcs, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0AD99-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTHQLRSRDI IALGFMTFAL FVGAGNIIFP PMVGLQAGEH VWTAAFGFLI
60 70 80 90 100
TAVGLPVLTV VALAKVGGGV DSLSTPIGKV AGVLLATVCY LAVGPLFATP
110 120 130 140 150
RTATVSFEVG IAPLTGDSAL PLFIYSLVYF AIVILVSLYP GKLLDTVGNF
160 170 180 190 200
LAPLKIIALV ILSVAAIVWP AGSISTATEA YQNAAFSNGF VNGYLTMDTL
210 220 230 240 250
GAMVFGIVIV NAARSRGVTE ARLLTRYTVW AGLMAGVGLT LLYLALFRLG
260 270 280 290 300
SDSASLVDQS ANGAAILHAY VQHTFGGGGS FLLAALIFIA CLVTAVGLTC
310 320 330 340 350
ACAEFFAQYV PLSYRTLVFI LGGFSMVVSN LGLSQLIQIS VPVLTAIYPP
360 370 380 390 400
CIALVVLSFT RSWWHNSSRV IAPPMFISLL FGILDGIKAS AFSDILPSWA
410 420 430
QRLPLAEQGL AWLMPTVVMV VLAIIWDRAA GRQVTSSAH
Length:439
Mass (Da):46,209
Last modified:December 6, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB30C3B5755738E0E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U73857 Genomic DNA Translation: AAB18125.1
U82664 Genomic DNA Translation: AAB40157.1
U00096 Genomic DNA Translation: AAC73504.1
AP009048 Genomic DNA Translation: BAE76181.1
X04704 Genomic DNA No translation available.

Protein sequence database of the Protein Information Resource

More...
PIRi
A64769

NCBI Reference Sequences

More...
RefSeqi
NP_414935.1, NC_000913.3
WP_000149639.1, NZ_SSZK01000009.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC73504; AAC73504; b0401
BAE76181; BAE76181; BAE76181

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57731577
945042

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW0391
eco:b0401

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.1876

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73857 Genomic DNA Translation: AAB18125.1
U82664 Genomic DNA Translation: AAB40157.1
U00096 Genomic DNA Translation: AAC73504.1
AP009048 Genomic DNA Translation: BAE76181.1
X04704 Genomic DNA No translation available.
PIRiA64769
RefSeqiNP_414935.1, NC_000913.3
WP_000149639.1, NZ_SSZK01000009.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4259819, 39 interactors
849431, 1 interactor
DIPiDIP-48078N
IntActiP0AD99, 1 interactor
STRINGi511145.b0401

Protein family/group databases

TCDBi2.A.26.1.10, the branched chain amino acid:cation symporter (livcs) family

Proteomic databases

PaxDbiP0AD99
PRIDEiP0AD99

Genome annotation databases

EnsemblBacteriaiAAC73504; AAC73504; b0401
BAE76181; BAE76181; BAE76181
GeneIDi57731577
945042
KEGGiecj:JW0391
eco:b0401
PATRICifig|1411691.4.peg.1876

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB2087

Phylogenomic databases

eggNOGiCOG1114, Bacteria
HOGENOMiCLU_036807_0_0_6
InParanoidiP0AD99
PhylomeDBiP0AD99

Enzyme and pathway databases

BioCyciEcoCyc:BRNQ-MONOMER
MetaCyc:BRNQ-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P0AD99

Family and domain databases

InterProiView protein in InterPro
IPR004685, Brnchd-chn_aa_trnsp_Livcs
PANTHERiPTHR30588, PTHR30588, 1 hit
PfamiView protein in Pfam
PF05525, Branch_AA_trans, 1 hit
TIGRFAMsiTIGR00796, livcs, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBRNQ_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0AD99
Secondary accession number(s): P37011
, P77112, P77492, Q2MC25
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: February 10, 2021
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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