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Protein

Leu/Ile/Val-binding protein

Gene

livJ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is a component of the leucine, isoleucine, valine, (threonine) transport system, which is one of the two periplasmic binding protein-dependent transport systems of the high-affinity transport of the branched-chain amino acids.

GO - Biological processi

  • isoleucine transport Source: EcoCyc
  • leucine transport Source: EcoCyc
  • valine transport Source: EcoCyc

Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:LIVJ-MONOMER
MetaCyc:LIVJ-MONOMER

Protein family/group databases

TCDBi3.A.1.4.1 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Leu/Ile/Val-binding protein
Short name:
LIV-BP
Gene namesi
Name:livJ
Ordered Locus Names:b3460, JW3425
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10539 livJ

Subcellular locationi

GO - Cellular componenti

  • outer membrane-bounded periplasmic space Source: EcoCyc

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 233 PublicationsAdd BLAST23
ChainiPRO_000001770024 – 367Leu/Ile/Val-binding proteinAdd BLAST344

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi76 ↔ 101

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP0AD96
PaxDbiP0AD96
PRIDEiP0AD96

2D gel databases

SWISS-2DPAGEiP0AD96

Interactioni

Protein-protein interaction databases

BioGridi4259328, 24 interactors
IntActiP0AD96, 4 interactors
STRINGi316385.ECDH10B_3634

Structurei

Secondary structure

1367
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP0AD96
SMRiP0AD96
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0AD96

Family & Domainsi

Sequence similaritiesi

Belongs to the leucine-binding protein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105CP9 Bacteria
COG0683 LUCA
HOGENOMiHOG000130989
InParanoidiP0AD96
KOiK01999
PhylomeDBiP0AD96

Family and domain databases

InterProiView protein in InterPro
IPR028081 Leu-bd
IPR000709 Leu_Ile_Val-bd
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF13458 Peripla_BP_6, 1 hit
PRINTSiPR00337 LEUILEVALBP
SUPFAMiSSF53822 SSF53822, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0AD96-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNIKGKALLA GCIALAFSNM ALAEDIKVAV VGAMSGPVAQ YGDQEFTGAE
60 70 80 90 100
QAVADINAKG GIKGNKLQIV KYDDACDPKQ AVAVANKVVN DGIKYVIGHL
110 120 130 140 150
CSSSTQPASD IYEDEGILMI TPAATAPELT ARGYQLILRT TGLDSDQGPT
160 170 180 190 200
AAKYILEKVK PQRIAIVHDK QQYGEGLARA VQDGLKKGNA NVVFFDGITA
210 220 230 240 250
GEKDFSTLVA RLKKENIDFV YYGGYHPEMG QILRQARAAG LKTQFMGPEG
260 270 280 290 300
VANVSLSNIA GESAEGLLVT KPKNYDQVPA NKPIVDAIKA KKQDPSGAFV
310 320 330 340 350
WTTYAALQSL QAGLNQSDDP AEIAKYLKAN SVDTVMGPLT WDEKGDLKGF
360
EFGVFDWHAN GTATDAK
Length:367
Mass (Da):39,076
Last modified:December 6, 2005 - v1
Checksum:i63F0729C251F18FD
GO

Sequence cautioni

The sequence AAB18435 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3I → T (PubMed:3891753).Curated1
Sequence conflicti3I → T (PubMed:4077929).Curated1
Sequence conflicti3I → T (PubMed:2195019).Curated1
Sequence conflicti12C → L (PubMed:3891753).Curated1
Sequence conflicti12C → L (PubMed:4077929).Curated1
Sequence conflicti12C → L (PubMed:2195019).Curated1
Sequence conflicti16A → G (PubMed:3891753).Curated1
Sequence conflicti70V → A (PubMed:3891753).Curated1
Sequence conflicti70V → A (PubMed:4077929).Curated1
Sequence conflicti70V → A (PubMed:2195019).Curated1
Sequence conflicti70V → A (PubMed:328304).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05516 Genomic DNA Translation: AAA83881.1
M29377 Genomic DNA Translation: AAA24075.1
U00039 Genomic DNA Translation: AAB18435.1 Different initiation.
U00096 Genomic DNA Translation: AAT48185.1
AP009048 Genomic DNA Translation: BAE77833.1
PIRiG65142 BLEC
RefSeqiWP_001021996.1, NZ_LN832404.1
YP_026223.1, NC_000913.3

Genome annotation databases

EnsemblBacteriaiAAT48185; AAT48185; b3460
BAE77833; BAE77833; BAE77833
GeneIDi947971
KEGGiecj:JW3425
eco:b3460
PATRICifig|511145.12.peg.3559

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05516 Genomic DNA Translation: AAA83881.1
M29377 Genomic DNA Translation: AAA24075.1
U00039 Genomic DNA Translation: AAB18435.1 Different initiation.
U00096 Genomic DNA Translation: AAT48185.1
AP009048 Genomic DNA Translation: BAE77833.1
PIRiG65142 BLEC
RefSeqiWP_001021996.1, NZ_LN832404.1
YP_026223.1, NC_000913.3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z15X-ray1.70A24-367[»]
1Z16X-ray1.72A24-367[»]
1Z17X-ray1.96A24-367[»]
1Z18X-ray2.10A24-367[»]
2LIVX-ray2.40A24-367[»]
ProteinModelPortaliP0AD96
SMRiP0AD96
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259328, 24 interactors
IntActiP0AD96, 4 interactors
STRINGi316385.ECDH10B_3634

Protein family/group databases

TCDBi3.A.1.4.1 the atp-binding cassette (abc) superfamily

2D gel databases

SWISS-2DPAGEiP0AD96

Proteomic databases

EPDiP0AD96
PaxDbiP0AD96
PRIDEiP0AD96

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT48185; AAT48185; b3460
BAE77833; BAE77833; BAE77833
GeneIDi947971
KEGGiecj:JW3425
eco:b3460
PATRICifig|511145.12.peg.3559

Organism-specific databases

EchoBASEiEB0534
EcoGeneiEG10539 livJ

Phylogenomic databases

eggNOGiENOG4105CP9 Bacteria
COG0683 LUCA
HOGENOMiHOG000130989
InParanoidiP0AD96
KOiK01999
PhylomeDBiP0AD96

Enzyme and pathway databases

BioCyciEcoCyc:LIVJ-MONOMER
MetaCyc:LIVJ-MONOMER

Miscellaneous databases

EvolutionaryTraceiP0AD96
PROiPR:P0AD96

Family and domain databases

InterProiView protein in InterPro
IPR028081 Leu-bd
IPR000709 Leu_Ile_Val-bd
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF13458 Peripla_BP_6, 1 hit
PRINTSiPR00337 LEUILEVALBP
SUPFAMiSSF53822 SSF53822, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLIVJ_ECOLI
AccessioniPrimary (citable) accession number: P0AD96
Secondary accession number(s): P02917
, P76698, Q2M7C3, Q8CVL7, Q8X6S2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: December 6, 2005
Last modified: November 7, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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