UniProtKB - P0AD96 (LIVJ_ECOLI)
Protein
Leu/Ile/Val-binding protein
Gene
livJ
Organism
Escherichia coli (strain K12)
Status
Functioni
This protein is a component of the leucine, isoleucine, valine, (threonine) transport system, which is one of the two periplasmic binding protein-dependent transport systems of the high-affinity transport of the branched-chain amino acids.
GO - Biological processi
- isoleucine transport Source: EcoCyc
- leucine transport Source: EcoCyc
- valine transport Source: EcoCyc
Keywordsi
Biological process | Amino-acid transport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:LIVJ-MONOMER MetaCyc:LIVJ-MONOMER |
Protein family/group databases
TCDBi | 3.A.1.4.1, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Leu/Ile/Val-binding proteinShort name: LIV-BP |
Gene namesi | Name:livJ Ordered Locus Names:b3460, JW3425 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Other locations
Other locations
- outer membrane-bounded periplasmic space Source: EcoCyc
Keywords - Cellular componenti
PeriplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | 3 PublicationsAdd BLAST | 23 | |
ChainiPRO_0000017700 | 24 – 367 | Leu/Ile/Val-binding proteinAdd BLAST | 344 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 76 ↔ 101 |
Keywords - PTMi
Disulfide bondProteomic databases
jPOSTi | P0AD96 |
PaxDbi | P0AD96 |
PRIDEi | P0AD96 |
2D gel databases
SWISS-2DPAGEi | P0AD96 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4259328, 24 interactors |
ComplexPortali | CPX-4316, Branched chain amino acid ABC transporter complex |
IntActi | P0AD96, 4 interactors |
STRINGi | 511145.b3460 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0AD96 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P0AD96 |
Family & Domainsi
Sequence similaritiesi
Belongs to the leucine-binding protein family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | COG0683, Bacteria |
HOGENOMi | CLU_027128_6_0_6 |
InParanoidi | P0AD96 |
PhylomeDBi | P0AD96 |
Family and domain databases
InterProi | View protein in InterPro IPR028081, Leu-bd IPR000709, Leu_Ile_Val-bd IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF13458, Peripla_BP_6, 1 hit |
PRINTSi | PR00337, LEUILEVALBP |
SUPFAMi | SSF53822, SSF53822, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P0AD96-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNIKGKALLA GCIALAFSNM ALAEDIKVAV VGAMSGPVAQ YGDQEFTGAE
60 70 80 90 100
QAVADINAKG GIKGNKLQIV KYDDACDPKQ AVAVANKVVN DGIKYVIGHL
110 120 130 140 150
CSSSTQPASD IYEDEGILMI TPAATAPELT ARGYQLILRT TGLDSDQGPT
160 170 180 190 200
AAKYILEKVK PQRIAIVHDK QQYGEGLARA VQDGLKKGNA NVVFFDGITA
210 220 230 240 250
GEKDFSTLVA RLKKENIDFV YYGGYHPEMG QILRQARAAG LKTQFMGPEG
260 270 280 290 300
VANVSLSNIA GESAEGLLVT KPKNYDQVPA NKPIVDAIKA KKQDPSGAFV
310 320 330 340 350
WTTYAALQSL QAGLNQSDDP AEIAKYLKAN SVDTVMGPLT WDEKGDLKGF
360
EFGVFDWHAN GTATDAK
Sequence cautioni
The sequence AAB18435 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 3 | I → T (PubMed:3891753).Curated | 1 | |
Sequence conflicti | 3 | I → T (PubMed:4077929).Curated | 1 | |
Sequence conflicti | 3 | I → T (PubMed:2195019).Curated | 1 | |
Sequence conflicti | 12 | C → L (PubMed:3891753).Curated | 1 | |
Sequence conflicti | 12 | C → L (PubMed:4077929).Curated | 1 | |
Sequence conflicti | 12 | C → L (PubMed:2195019).Curated | 1 | |
Sequence conflicti | 16 | A → G (PubMed:3891753).Curated | 1 | |
Sequence conflicti | 70 | V → A (PubMed:3891753).Curated | 1 | |
Sequence conflicti | 70 | V → A (PubMed:4077929).Curated | 1 | |
Sequence conflicti | 70 | V → A (PubMed:2195019).Curated | 1 | |
Sequence conflicti | 70 | V → A (PubMed:328304).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J05516 Genomic DNA Translation: AAA83881.1 M29377 Genomic DNA Translation: AAA24075.1 U00039 Genomic DNA Translation: AAB18435.1 Different initiation. U00096 Genomic DNA Translation: AAT48185.1 AP009048 Genomic DNA Translation: BAE77833.1 |
PIRi | G65142, BLEC |
RefSeqi | WP_001021996.1, NZ_SSZK01000008.1 YP_026223.1, NC_000913.3 |
Genome annotation databases
EnsemblBacteriai | AAT48185; AAT48185; b3460 BAE77833; BAE77833; BAE77833 |
GeneIDi | 58388350 947971 |
KEGGi | ecj:JW3425 eco:b3460 |
PATRICi | fig|511145.12.peg.3559 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J05516 Genomic DNA Translation: AAA83881.1 M29377 Genomic DNA Translation: AAA24075.1 U00039 Genomic DNA Translation: AAB18435.1 Different initiation. U00096 Genomic DNA Translation: AAT48185.1 AP009048 Genomic DNA Translation: BAE77833.1 |
PIRi | G65142, BLEC |
RefSeqi | WP_001021996.1, NZ_SSZK01000008.1 YP_026223.1, NC_000913.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1Z15 | X-ray | 1.70 | A | 24-367 | [»] | |
1Z16 | X-ray | 1.72 | A | 24-367 | [»] | |
1Z17 | X-ray | 1.96 | A | 24-367 | [»] | |
1Z18 | X-ray | 2.10 | A | 24-367 | [»] | |
2LIV | X-ray | 2.40 | A | 24-367 | [»] | |
SMRi | P0AD96 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4259328, 24 interactors |
ComplexPortali | CPX-4316, Branched chain amino acid ABC transporter complex |
IntActi | P0AD96, 4 interactors |
STRINGi | 511145.b3460 |
Protein family/group databases
TCDBi | 3.A.1.4.1, the atp-binding cassette (abc) superfamily |
2D gel databases
SWISS-2DPAGEi | P0AD96 |
Proteomic databases
jPOSTi | P0AD96 |
PaxDbi | P0AD96 |
PRIDEi | P0AD96 |
Genome annotation databases
EnsemblBacteriai | AAT48185; AAT48185; b3460 BAE77833; BAE77833; BAE77833 |
GeneIDi | 58388350 947971 |
KEGGi | ecj:JW3425 eco:b3460 |
PATRICi | fig|511145.12.peg.3559 |
Organism-specific databases
EchoBASEi | EB0534 |
Phylogenomic databases
eggNOGi | COG0683, Bacteria |
HOGENOMi | CLU_027128_6_0_6 |
InParanoidi | P0AD96 |
PhylomeDBi | P0AD96 |
Enzyme and pathway databases
BioCyci | EcoCyc:LIVJ-MONOMER MetaCyc:LIVJ-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P0AD96 |
PROi | PR:P0AD96 |
Family and domain databases
InterProi | View protein in InterPro IPR028081, Leu-bd IPR000709, Leu_Ile_Val-bd IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF13458, Peripla_BP_6, 1 hit |
PRINTSi | PR00337, LEUILEVALBP |
SUPFAMi | SSF53822, SSF53822, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LIVJ_ECOLI | |
Accessioni | P0AD96Primary (citable) accession number: P0AD96 Secondary accession number(s): P02917 Q8X6S2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | December 6, 2005 | |
Last modified: | April 7, 2021 | |
This is version 114 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families