ID   LPT_ECOLI               Reviewed;          21 AA.
AC   P0AD86; P03059; Q2MCI0; Q6LEL1;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   24-JAN-2024, entry version 95.
DE   RecName: Full=thr operon leader peptide {ECO:0000255|HAMAP-Rule:MF_01907};
DE   AltName: Full=thr operon attenuator {ECO:0000255|HAMAP-Rule:MF_01907};
GN   Name=thrL {ECO:0000255|HAMAP-Rule:MF_01907};
GN   OrderedLocusNames=b0001, JW4367;
OS   Escherichia coli (strain K12).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=287010; DOI=10.1073/pnas.76.4.1706;
RA   Gardner J.F.;
RT   "Regulation of the threonine operon: tandem threonine and isoleucine codons
RT   in the control region and translational control of transcription
RT   termination.";
RL   Proc. Natl. Acad. Sci. U.S.A. 76:1706-1710(1979).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6277952; DOI=10.1016/s0021-9258(18)34867-1;
RA   Gardner J.F.;
RT   "Initiation, pausing, and termination of transcription in the threonine
RT   operon regulatory region of Escherichia coli.";
RL   J. Biol. Chem. 257:3896-3904(1982).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2410621; DOI=10.1016/0022-2836(85)90169-x;
RA   Lynn S.P., Bauer C.E., Chapman K.A., Gardner J.F.;
RT   "Identification and characterization of mutants affecting transcription
RT   termination at the threonine operon attenuator.";
RL   J. Mol. Biol. 183:529-541(1985).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA   Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT   "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT   from 92.8 through 100 minutes.";
RL   Nucleic Acids Res. 23:2105-2119(1995).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
CC   -!- FUNCTION: This protein is involved in control of the biosynthesis of
CC       threonine.
CC   -!- SIMILARITY: Belongs to the thr operon leader peptide family.
CC       {ECO:0000255|HAMAP-Rule:MF_01907}.
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DR   EMBL; J01706; AAA83913.1; -; Genomic_DNA.
DR   EMBL; V00360; CAA23658.1; -; Genomic_DNA.
DR   EMBL; X68872; CAA48733.1; -; Genomic_DNA.
DR   EMBL; M28570; AAA24672.1; -; Genomic_DNA.
DR   EMBL; U14003; AAA97300.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC73112.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76026.1; -; Genomic_DNA.
DR   PIR; A03595; LFECT.
DR   RefSeq; NP_414542.1; NC_000913.3.
DR   RefSeq; WP_001386572.1; NZ_STEB01000033.1.
DR   AlphaFoldDB; P0AD86; -.
DR   BioGRID; 4261932; 4.
DR   STRING; 511145.b0001; -.
DR   PaxDb; 511145-b0001; -.
DR   EnsemblBacteria; AAC73112; AAC73112; b0001.
DR   GeneID; 84238046; -.
DR   GeneID; 944742; -.
DR   KEGG; ecj:JW4367; -.
DR   KEGG; eco:b0001; -.
DR   EchoBASE; EB1255; -.
DR   HOGENOM; CLU_221491_0_1_6; -.
DR   InParanoid; P0AD86; -.
DR   BioCyc; EcoCyc:EG11277-MONOMER; -.
DR   PRO; PR:P0AD86; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0031555; P:transcriptional attenuation; IMP:EcoCyc.
DR   GO; GO:0031556; P:transcriptional attenuation by ribosome; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01907; Leader_Thr; 1.
DR   InterPro; IPR011720; Thr_lead_pept.
DR   NCBIfam; TIGR02077; thr_lead_pep; 1.
DR   Pfam; PF08254; Leader_Thr; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Leader peptide; Reference proteome;
KW   Threonine biosynthesis.
FT   PEPTIDE         1..21
FT                   /note="thr operon leader peptide"
FT                   /id="PRO_0000044007"
SQ   SEQUENCE   21 AA;  2138 MW;  6A9C9167F89EECE4 CRC64;
     MKRISTTITT TITITTGNGA G
//