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UniProtKB - P0AD63 (BLA1_ECOLX)
Protein
Beta-lactamase SHV-1
Gene
bla
Organism
Escherichia coli
Status
Functioni
Catalytic activityi
- EC:3.5.2.6PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 66 | Acyl-ester intermediatePROSITE-ProRule annotation | 1 | |
Active sitei | 164 | Proton acceptorBy similarity | 1 |
GO - Molecular functioni
- beta-lactamase activity Source: UniProtKB-EC
GO - Biological processi
- beta-lactam antibiotic catabolic process Source: InterPro
- response to antibiotic Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase |
Biological process | Antibiotic resistance |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:bla Synonyms:shv1 |
Encoded oni | Plasmid p4532 Publications |
Organismi | Escherichia coli |
Taxonomic identifieri | 562 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia |
Pathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL5956 |
DrugBanki | DB03445, (3S)-3-(dioxidosulfanyl)-N-[(1E)-3-oxoprop-1-en-1-yl]-4-(1H-1,2,3-triazol-1-yl)-D-valine DB03834, (3S)-3-(dioxidosulfanyl)-N-[(1Z)-3-oxoprop-1-en-1-yl]-4-(1H-1,2,3-triazol-1-yl)-D-valine DB03970, (7R)-7-(6,7-Dihydro-5H-cyclopenta[d]imidazo[2,1-b][1,3]thiazol-2-yl)-2,7-dihydro-1,4-thiazepine-3,6-dicarboxylic acid DB02579, Acrylic Acid DB09060, Avibactam DB03472, Cyclohexyl-Hexyl-Beta-D-Maltoside DB01598, Imipenem DB03057, Malonaldehyde DB12377, Relebactam DB01606, Tazobactam |
DrugCentrali | P0AD63 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | 2 PublicationsAdd BLAST | 21 | |
ChainiPRO_0000016980 | 22 – 286 | Beta-lactamase SHV-1Add BLAST | 265 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 73 ↔ 119 | By similarity |
Keywords - PTMi
Disulfide bondFamily & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 230 – 232 | Substrate bindingBy similarity | 3 |
Sequence similaritiesi
Belongs to the class-A beta-lactamase family.Curated
Keywords - Domaini
SignalFamily and domain databases
Gene3Di | 3.40.710.10, 1 hit |
InterProi | View protein in InterPro IPR012338, Beta-lactam/transpept-like IPR045155, Beta-lactam_cat IPR000871, Beta-lactam_class-A IPR023650, Beta-lactam_class-A_AS |
PANTHERi | PTHR35333, PTHR35333, 1 hit |
Pfami | View protein in Pfam PF13354, Beta-lactamase2, 1 hit |
PRINTSi | PR00118, BLACTAMASEA |
SUPFAMi | SSF56601, SSF56601, 1 hit |
PROSITEi | View protein in PROSITE PS00146, BETA_LACTAMASE_A, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P0AD63-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRYIRLCIIS LLATLPLAVH ASPQPLEQIK LSESQLSGRV GMIEMDLASG
60 70 80 90 100
RTLTAWRADE RFPMMSTFKV VLCGAVLARV DAGDEQLERK IHYRQQDLVD
110 120 130 140 150
YSPVSEKHLA DGMTVGELCA AAITMSDNSA ANLLLATVGG PAGLTAFLRQ
160 170 180 190 200
IGDNVTRLDR WETELNEALP GDARDTTTPA SMAATLRKLL TSQRLSARSQ
210 220 230 240 250
RQLLQWMVDD RVAGPLIRSV LPAGWFIADK TGAGERGARG IVALLGPNNK
260 270 280
AERIVVIYLR DTPASMAERN QQIAGIGAAL IEHWQR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 136 – 137 | AT → TA AA sequence (PubMed:3260490).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF148850 Genomic DNA Translation: AAD37412.1 |
RefSeqi | WP_001620095.1, NZ_VKYG01000130.1 |
Genome annotation databases
KEGGi | ag:AAD37412 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF148850 Genomic DNA Translation: AAD37412.1 |
RefSeqi | WP_001620095.1, NZ_VKYG01000130.1 |
3D structure databases
AlphaFoldDBi | P0AD63 |
SMRi | P0AD63 |
ModBasei | Search... |
Chemistry databases
BindingDBi | P0AD63 |
ChEMBLi | CHEMBL5956 |
DrugBanki | DB03445, (3S)-3-(dioxidosulfanyl)-N-[(1E)-3-oxoprop-1-en-1-yl]-4-(1H-1,2,3-triazol-1-yl)-D-valine DB03834, (3S)-3-(dioxidosulfanyl)-N-[(1Z)-3-oxoprop-1-en-1-yl]-4-(1H-1,2,3-triazol-1-yl)-D-valine DB03970, (7R)-7-(6,7-Dihydro-5H-cyclopenta[d]imidazo[2,1-b][1,3]thiazol-2-yl)-2,7-dihydro-1,4-thiazepine-3,6-dicarboxylic acid DB02579, Acrylic Acid DB09060, Avibactam DB03472, Cyclohexyl-Hexyl-Beta-D-Maltoside DB01598, Imipenem DB03057, Malonaldehyde DB12377, Relebactam DB01606, Tazobactam |
DrugCentrali | P0AD63 |
Genome annotation databases
KEGGi | ag:AAD37412 |
Family and domain databases
Gene3Di | 3.40.710.10, 1 hit |
InterProi | View protein in InterPro IPR012338, Beta-lactam/transpept-like IPR045155, Beta-lactam_cat IPR000871, Beta-lactam_class-A IPR023650, Beta-lactam_class-A_AS |
PANTHERi | PTHR35333, PTHR35333, 1 hit |
Pfami | View protein in Pfam PF13354, Beta-lactamase2, 1 hit |
PRINTSi | PR00118, BLACTAMASEA |
SUPFAMi | SSF56601, SSF56601, 1 hit |
PROSITEi | View protein in PROSITE PS00146, BETA_LACTAMASE_A, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | BLA1_ECOLX | |
Accessioni | P0AD63Primary (citable) accession number: P0AD63 Secondary accession number(s): O07941, P14557, P23982 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2005 |
Last sequence update: | December 6, 2005 | |
Last modified: | May 25, 2022 | |
This is version 61 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, PlasmidDocuments
- SIMILARITY comments
Index of protein domains and families