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Entry version 105 (07 Oct 2020)
Sequence version 1 (22 Nov 2005)
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Protein

Inner membrane protein YejM

Gene

yejM

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:EG12049-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.127.1.2, the enterobacterial cardiolipin transporter (clt) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inner membrane protein YejM
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:yejM
Synonyms:yejN
Ordered Locus Names:b2188, JW2176
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei21 – 43HelicalSequence analysisAdd BLAST23
Topological domaini44 – 57PeriplasmicSequence analysisAdd BLAST14
Transmembranei58 – 80HelicalSequence analysisAdd BLAST23
Topological domaini81 – 84CytoplasmicSequence analysis4
Transmembranei85 – 103HelicalSequence analysisAdd BLAST19
Topological domaini104 – 134PeriplasmicSequence analysisAdd BLAST31
Transmembranei135 – 157HelicalSequence analysisAdd BLAST23
Topological domaini158 – 168CytoplasmicSequence analysisAdd BLAST11
Transmembranei169 – 191HelicalSequence analysisAdd BLAST23
Topological domaini192 – 586PeriplasmicSequence analysisAdd BLAST395

GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001691651 – 586Inner membrane protein YejMAdd BLAST586

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P0AD27

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0AD27

PRoteomics IDEntifications database

More...
PRIDEi
P0AD27

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4260478, 16 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b2188

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1586
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P0AD27

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

To H.influenzae HI_0842.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
COG3083, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_030247_1_0_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0AD27

KEGG Orthology (KO)

More...
KOi
K07014

Family and domain databases

Database of protein disorder

More...
DisProti
DP02484

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.720.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017850, Alkaline_phosphatase_core_sf
IPR000917, Sulfatase_N
IPR012159, YejM
IPR024588, YejM_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11893, DUF3413, 1 hit
PF00884, Sulfatase, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF004950, Mmb_sulf_HI0842, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53649, SSF53649, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0AD27-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVTHRQRYRE KVSQMVSWGH WFALFNILLS LVIGSRYLFI ADWPTTLAGR
60 70 80 90 100
IYSYVSIIGH FSFLVFATYL LILFPLTFIV GSQRLMRFLS VILATAGMTL
110 120 130 140 150
LLIDSEVFTR FHLHLNPIVW QLVINPDENE MARDWQLMFI SVPVILLLEL
160 170 180 190 200
VFATWSWQKL RSLTRRRRFA RPLAAFLFIA FIASHVVYIW ADANFYRPIT
210 220 230 240 250
MQRANLPLSY PMTARRFLEK HGLLDAQEYQ RRLIEQGNPD AVSVQYPLSE
260 270 280 290 300
LRYRDMGTGQ NVLLITVDGL NYSRFEKQMP ALAGFAEQNI SFTRHMSSGN
310 320 330 340 350
TTDNGIFGLF YGISPSYMDG ILSTRTPAAL ITALNQQGYQ LGLFSSDGFT
360 370 380 390 400
SPLYRQALLS DFSMPSVRTQ SDEQTATQWI NWLGRYAQED NRWFSWVSFN
410 420 430 440 450
GTNIDDSNQQ AFARKYSRAA GNVDDQINRV LNALRDSGKL DNTVVIITAG
460 470 480 490 500
RGIPLSEEEE TFDWSHGHLQ VPLVIHWPGT PAQRINALTD HTDLMTTLMQ
510 520 530 540 550
RLLHVSTPAS EYSQGQDLFN PQRRHYWVTA ADNDTLAITT PKKTLVLNNN
560 570 580
GKYRTYNLRG ERVKDEKPQL SLLLQVLTDE KRFIAN
Length:586
Mass (Da):67,296
Last modified:November 22, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0460F8C00A0D5465
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U00008 Genomic DNA Translation: AAA16384.1
U00096 Genomic DNA Translation: AAC75249.1
AP009048 Genomic DNA Translation: BAE76653.1

Protein sequence database of the Protein Information Resource

More...
PIRi
C64988

NCBI Reference Sequences

More...
RefSeqi
NP_416693.1, NC_000913.3
WP_000256203.1, NZ_STEB01000002.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC75249; AAC75249; b2188
BAE76653; BAE76653; BAE76653

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
49583991
946685

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW2176
eco:b2188

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.47

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00008 Genomic DNA Translation: AAA16384.1
U00096 Genomic DNA Translation: AAC75249.1
AP009048 Genomic DNA Translation: BAE76653.1
PIRiC64988
RefSeqiNP_416693.1, NC_000913.3
WP_000256203.1, NZ_STEB01000002.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5I5HX-ray1.65A1-586[»]
SMRiP0AD27
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi4260478, 16 interactors
STRINGi511145.b2188

Protein family/group databases

TCDBi2.A.127.1.2, the enterobacterial cardiolipin transporter (clt) family

Proteomic databases

jPOSTiP0AD27
PaxDbiP0AD27
PRIDEiP0AD27

Genome annotation databases

EnsemblBacteriaiAAC75249; AAC75249; b2188
BAE76653; BAE76653; BAE76653
GeneIDi49583991
946685
KEGGiecj:JW2176
eco:b2188
PATRICifig|1411691.4.peg.47

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB1981

Phylogenomic databases

eggNOGiCOG3083, Bacteria
HOGENOMiCLU_030247_1_0_6
InParanoidiP0AD27
KOiK07014

Enzyme and pathway databases

BioCyciEcoCyc:EG12049-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P0AD27

Family and domain databases

DisProtiDP02484
Gene3Di3.40.720.10, 1 hit
InterProiView protein in InterPro
IPR017850, Alkaline_phosphatase_core_sf
IPR000917, Sulfatase_N
IPR012159, YejM
IPR024588, YejM_N
PfamiView protein in Pfam
PF11893, DUF3413, 1 hit
PF00884, Sulfatase, 1 hit
PIRSFiPIRSF004950, Mmb_sulf_HI0842, 1 hit
SUPFAMiSSF53649, SSF53649, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYEJM_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0AD27
Secondary accession number(s): P33922, P33923, Q2MAQ3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: October 7, 2020
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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