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UniProtKB - P0ACZ2 (ETP_ECOLI)
Protein
Low molecular weight protein-tyrosine-phosphatase Etp
Gene
etp
Organism
Escherichia coli (strain K12)
Status
Functioni
Dephosphorylates etk.
Caution
In E.coli K12 / MG1655 and K12 / W3110 this operon is silenced by an IS1D insertion in the promoter region.Curated
Catalytic activityi
- EC:3.1.3.48
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 13 | NucleophileBy similarity | 1 | |
Active sitei | 19 | By similarity | 1 | |
Active sitei | 119 | Proton donorBy similarity | 1 |
GO - Molecular functioni
- protein tyrosine phosphatase activity Source: EcoCyc
GO - Biological processi
- peptidyl-tyrosine dephosphorylation Source: EcoCyc
Keywordsi
Molecular function | Hydrolase, Protein phosphatase |
Enzyme and pathway databases
BioCyci | EcoCyc:G6503-MONOMER |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:etp Synonyms:yccY Ordered Locus Names:b0982, JW5132 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046576 | 1 – 148 | Low molecular weight protein-tyrosine-phosphatase EtpAdd BLAST | 148 |
Proteomic databases
PaxDbi | P0ACZ2 |
PRIDEi | P0ACZ2 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4261407, 378 interactors |
STRINGi | 511145.b0982 |
Family & Domainsi
Sequence similaritiesi
Belongs to the low molecular weight phosphotyrosine protein phosphatase family.Curated
Phylogenomic databases
eggNOGi | COG0394, Bacteria |
HOGENOMi | CLU_071415_1_1_6 |
InParanoidi | P0ACZ2 |
OMAi | AFFPQKA |
PhylomeDBi | P0ACZ2 |
Family and domain databases
InterProi | View protein in InterPro IPR023485, Ptyr_pPase IPR036196, Ptyr_pPase_sf IPR017867, Tyr_phospatase_low_mol_wt |
Pfami | View protein in Pfam PF01451, LMWPc, 1 hit |
PRINTSi | PR00719, LMWPTPASE |
SMARTi | View protein in SMART SM00226, LMWPc, 1 hit |
SUPFAMi | SSF52788, SSF52788, 1 hit |
i Sequence
Sequence statusi: Complete.
P0ACZ2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAQLKFNSIL VVCTGNICRS PIGERLLRKR LPGVKVKSAG VHGLVKHPAD
60 70 80 90 100
ATAADVAANH GVSLEGHAGR KLTAEMARNY DLILAMESEH IAQVTAIAPE
110 120 130 140
VRGKTMLFGQ WLEQKEIPDP YRKSQDAFEH VYGMLERASQ EWAKRLSR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74067.2 AP009048 Genomic DNA Translation: BAA35747.2 |
PIRi | D64839 |
RefSeqi | NP_415502.4, NC_000913.3 WP_000057871.1, NZ_STEB01000006.1 |
Genome annotation databases
EnsemblBacteriai | AAC74067; AAC74067; b0982 BAA35747; BAA35747; BAA35747 |
GeneIDi | 66670741 945236 |
KEGGi | ecj:JW5132 eco:b0982 |
PATRICi | fig|1411691.4.peg.1291 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74067.2 AP009048 Genomic DNA Translation: BAA35747.2 |
PIRi | D64839 |
RefSeqi | NP_415502.4, NC_000913.3 WP_000057871.1, NZ_STEB01000006.1 |
3D structure databases
AlphaFoldDBi | P0ACZ2 |
SMRi | P0ACZ2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4261407, 378 interactors |
STRINGi | 511145.b0982 |
Proteomic databases
PaxDbi | P0ACZ2 |
PRIDEi | P0ACZ2 |
Genome annotation databases
EnsemblBacteriai | AAC74067; AAC74067; b0982 BAA35747; BAA35747; BAA35747 |
GeneIDi | 66670741 945236 |
KEGGi | ecj:JW5132 eco:b0982 |
PATRICi | fig|1411691.4.peg.1291 |
Organism-specific databases
EchoBASEi | EB3491 |
Phylogenomic databases
eggNOGi | COG0394, Bacteria |
HOGENOMi | CLU_071415_1_1_6 |
InParanoidi | P0ACZ2 |
OMAi | AFFPQKA |
PhylomeDBi | P0ACZ2 |
Enzyme and pathway databases
BioCyci | EcoCyc:G6503-MONOMER |
Miscellaneous databases
PROi | PR:P0ACZ2 |
Family and domain databases
InterProi | View protein in InterPro IPR023485, Ptyr_pPase IPR036196, Ptyr_pPase_sf IPR017867, Tyr_phospatase_low_mol_wt |
Pfami | View protein in Pfam PF01451, LMWPc, 1 hit |
PRINTSi | PR00719, LMWPTPASE |
SMARTi | View protein in SMART SM00226, LMWPc, 1 hit |
SUPFAMi | SSF52788, SSF52788, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ETP_ECOLI | |
Accessioni | P0ACZ2Primary (citable) accession number: P0ACZ2 Secondary accession number(s): P75880, Q8XC24 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2005 |
Last sequence update: | November 22, 2005 | |
Last modified: | May 25, 2022 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families