UniProtKB - P0ACV4 (LAPA_ECOLI)
Protein
Lipopolysaccharide assembly protein A
Gene
lapA
Organism
Escherichia coli (strain K12)
Status
Functioni
Involved in the assembly of lipopolysaccharide (LPS).UniRule annotation1 Publication
GO - Biological processi
- lipopolysaccharide metabolic process Source: InterPro
Keywordsi
Biological process | Stress response |
Enzyme and pathway databases
BioCyci | EcoCyc:G6637-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Lipopolysaccharide assembly protein A1 PublicationUniRule annotation |
Gene namesi | Name:lapA1 PublicationUniRule annotation Synonyms:yciS Ordered Locus Names:b1279, JW1271 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane UniRule annotation2 Publications; Multi-pass membrane protein UniRule annotation
Note: Copurifies with LptE/LptD, LptBFGC, LptA, DnaK/DnaJ and LPS.1 Publication
Plasma Membrane
- integral component of plasma membrane Source: EcoCyc
- plasma membrane Source: EcoCyc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 2 | CytoplasmicCurated | 2 | |
Transmembranei | 3 – 23 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 24 – 43 | PeriplasmicCuratedAdd BLAST | 20 | |
Transmembranei | 44 – 64 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 65 – 102 | Cytoplasmic1 PublicationAdd BLAST | 38 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Disruption mutant shows accumulation of a few incomplete LPS precursors.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000168886 | 1 – 102 | Lipopolysaccharide assembly protein AAdd BLAST | 102 |
Proteomic databases
jPOSTi | P0ACV4 |
PaxDbi | P0ACV4 |
PRIDEi | P0ACV4 |
Expressioni
Inductioni
Induced by heat shock, via RpoH.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260130, 32 interactors |
DIPi | DIP-47880N |
IntActi | P0ACV4, 20 interactors |
STRINGi | 511145.b1279 |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 64 – 92 | UniRule annotationAdd BLAST | 29 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG3771, Bacteria |
HOGENOMi | CLU_160072_0_0_6 |
Family and domain databases
HAMAPi | MF_01948, LPS_assembly_LapA, 1 hit |
InterProi | View protein in InterPro IPR032906, LapA IPR010445, LapA_dom |
Pfami | View protein in Pfam PF06305, LapA_dom, 1 hit |
i Sequence
Sequence statusi: Complete.
P0ACV4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKYLLIFLLV LAIFVISVTL GAQNDQQVTF NYLLAQGEYR ISTLLAVLFA
60 70 80 90 100
AGFAIGWLIC GLFWLRVRVS LARAERKIKR LENQLSPATD VAVVPHSSAA
KE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74361.1 AP009048 Genomic DNA Translation: BAA14833.1 |
PIRi | B64876 |
RefSeqi | NP_415795.1, NC_000913.3 WP_000876286.1, NZ_STEB01000005.1 |
Genome annotation databases
EnsemblBacteriai | AAC74361; AAC74361; b1279 BAA14833; BAA14833; BAA14833 |
GeneIDi | 58388641 944936 |
KEGGi | ecj:JW1271 eco:b1279 |
PATRICi | fig|1411691.4.peg.1002 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74361.1 AP009048 Genomic DNA Translation: BAA14833.1 |
PIRi | B64876 |
RefSeqi | NP_415795.1, NC_000913.3 WP_000876286.1, NZ_STEB01000005.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4260130, 32 interactors |
DIPi | DIP-47880N |
IntActi | P0ACV4, 20 interactors |
STRINGi | 511145.b1279 |
Proteomic databases
jPOSTi | P0ACV4 |
PaxDbi | P0ACV4 |
PRIDEi | P0ACV4 |
Genome annotation databases
EnsemblBacteriai | AAC74361; AAC74361; b1279 BAA14833; BAA14833; BAA14833 |
GeneIDi | 58388641 944936 |
KEGGi | ecj:JW1271 eco:b1279 |
PATRICi | fig|1411691.4.peg.1002 |
Organism-specific databases
EchoBASEi | EB3663 |
Phylogenomic databases
eggNOGi | COG3771, Bacteria |
HOGENOMi | CLU_160072_0_0_6 |
Enzyme and pathway databases
BioCyci | EcoCyc:G6637-MONOMER |
Miscellaneous databases
PROi | PR:P0ACV4 |
Family and domain databases
HAMAPi | MF_01948, LPS_assembly_LapA, 1 hit |
InterProi | View protein in InterPro IPR032906, LapA IPR010445, LapA_dom |
Pfami | View protein in Pfam PF06305, LapA_dom, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LAPA_ECOLI | |
Accessioni | P0ACV4Primary (citable) accession number: P0ACV4 Secondary accession number(s): P77614 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2005 |
Last sequence update: | November 22, 2005 | |
Last modified: | February 10, 2021 | |
This is version 98 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families