UniProtKB - P0ACS7 (RPIR_ECOLI)
Protein
HTH-type transcriptional regulator RpiR
Gene
rpiR
Organism
Escherichia coli (strain K12)
Status
Functioni
Regulatory protein involved in rpiB gene repression. Also involved in als operon repression.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 50 – 69 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 20 |
GO - Molecular functioni
- carbohydrate derivative binding Source: InterPro
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: GO_Central
GO - Biological processi
- carbohydrate derivative metabolic process Source: InterPro
- negative regulation of transcription, DNA-templated Source: EcoCyc
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
BioCyci | EcoCyc:G7821-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: HTH-type transcriptional regulator RpiRAlternative name(s): Als operon repressor |
Gene namesi | Name:rpiR Synonyms:alsR, yjcY Ordered Locus Names:b4089, JW4050 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000068620 | 1 – 296 | HTH-type transcriptional regulator RpiRAdd BLAST | 296 |
Proteomic databases
jPOSTi | P0ACS7 |
PaxDbi | P0ACS7 |
PRIDEi | P0ACS7 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4262682, 11 interactors |
IntActi | P0ACS7, 5 interactors |
STRINGi | 511145.b4089 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 90 | HTH rpiR-typePROSITE-ProRule annotationAdd BLAST | 77 | |
Domaini | 134 – 274 | SISPROSITE-ProRule annotationAdd BLAST | 141 |
Phylogenomic databases
eggNOGi | COG1737, Bacteria |
HOGENOMi | CLU_055769_0_5_6 |
InParanoidi | P0ACS7 |
PhylomeDBi | P0ACS7 |
Family and domain databases
CDDi | cd05013, SIS_RpiR, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR000281, HTH_RpiR IPR035472, RpiR-like_SIS IPR001347, SIS IPR036388, WH-like_DNA-bd_sf |
Pfami | View protein in Pfam PF01418, HTH_6, 1 hit PF01380, SIS, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS51071, HTH_RPIR, 1 hit PS51464, SIS, 1 hit |
i Sequence
Sequence statusi: Complete.
P0ACS7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQSEFDSAL PNGIGLAPYL RMKQEGMTEN ESRIVEWLLK PGNLSCAPAI
60 70 80 90 100
KDVAEALAVS EAMIVKVSKL LGFSGFRNLR SALEDYFSQS EQVLPSELAF
110 120 130 140 150
DEAPQDVVNK VFNITLRTIM EGQSIVNVDE IHRAARFFYQ ARQRDLYGAG
160 170 180 190 200
GSNAICADVQ HKFLRIGVRC QAYPDAHIMM MSASLLQEGD VVLVVTHSGR
210 220 230 240 250
TSDVKAAVEL AKKNGAKIIC ITHSYHSPIA KLADYIICSP APETPLLGRN
260 270 280 290
ASARILQLTL LDAFFVSVAQ LNIEQANINM QKTGAIVDFF SPGALK
Sequence cautioni
The sequence AAA96988 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X82203 Genomic DNA Translation: CAA57687.1 U14003 Genomic DNA Translation: AAA96988.1 Different initiation. U00096 Genomic DNA Translation: AAC77050.2 AP009048 Genomic DNA Translation: BAE78092.1 |
PIRi | S56317 |
RefSeqi | NP_418513.4, NC_000913.3 WP_000083216.1, NZ_STEB01000014.1 |
Genome annotation databases
EnsemblBacteriai | AAC77050; AAC77050; b4089 BAE78092; BAE78092; BAE78092 |
GeneIDi | 57730586 948603 |
KEGGi | ecj:JW4050 eco:b4089 |
PATRICi | fig|511145.12.peg.4216 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X82203 Genomic DNA Translation: CAA57687.1 U14003 Genomic DNA Translation: AAA96988.1 Different initiation. U00096 Genomic DNA Translation: AAC77050.2 AP009048 Genomic DNA Translation: BAE78092.1 |
PIRi | S56317 |
RefSeqi | NP_418513.4, NC_000913.3 WP_000083216.1, NZ_STEB01000014.1 |
3D structure databases
SMRi | P0ACS7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4262682, 11 interactors |
IntActi | P0ACS7, 5 interactors |
STRINGi | 511145.b4089 |
Proteomic databases
jPOSTi | P0ACS7 |
PaxDbi | P0ACS7 |
PRIDEi | P0ACS7 |
Protocols and materials databases
DNASUi | 948603 |
Genome annotation databases
EnsemblBacteriai | AAC77050; AAC77050; b4089 BAE78092; BAE78092; BAE78092 |
GeneIDi | 57730586 948603 |
KEGGi | ecj:JW4050 eco:b4089 |
PATRICi | fig|511145.12.peg.4216 |
Organism-specific databases
EchoBASEi | EB2353 |
Phylogenomic databases
eggNOGi | COG1737, Bacteria |
HOGENOMi | CLU_055769_0_5_6 |
InParanoidi | P0ACS7 |
PhylomeDBi | P0ACS7 |
Enzyme and pathway databases
BioCyci | EcoCyc:G7821-MONOMER |
Miscellaneous databases
PROi | PR:P0ACS7 |
Family and domain databases
CDDi | cd05013, SIS_RpiR, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR000281, HTH_RpiR IPR035472, RpiR-like_SIS IPR001347, SIS IPR036388, WH-like_DNA-bd_sf |
Pfami | View protein in Pfam PF01418, HTH_6, 1 hit PF01380, SIS, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS51071, HTH_RPIR, 1 hit PS51464, SIS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RPIR_ECOLI | |
Accessioni | P0ACS7Primary (citable) accession number: P0ACS7 Secondary accession number(s): P39266, P76791, Q2M6L4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2005 |
Last sequence update: | November 22, 2005 | |
Last modified: | February 10, 2021 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |