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Protein

HTH-type transcriptional regulator RpiR

Gene

rpiR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory protein involved in rpiB gene repression. Also involved in als operon repression.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi50 – 69H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:G7821-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator RpiR
Alternative name(s):
Als operon repressor
Gene namesi
Name:rpiR
Synonyms:alsR, yjcY
Ordered Locus Names:b4089, JW4050
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12459 rpiR

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000686201 – 296HTH-type transcriptional regulator RpiRAdd BLAST296

Proteomic databases

PaxDbiP0ACS7
PRIDEiP0ACS7

Interactioni

Protein-protein interaction databases

BioGridi4262682, 11 interactors
IntActiP0ACS7, 5 interactors
STRINGi316385.ECDH10B_4280

Structurei

3D structure databases

ProteinModelPortaliP0ACS7
SMRiP0ACS7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 90HTH rpiR-typePROSITE-ProRule annotationAdd BLAST77
Domaini134 – 274SISPROSITE-ProRule annotationAdd BLAST141

Phylogenomic databases

eggNOGiENOG4105NYY Bacteria
COG1737 LUCA
HOGENOMiHOG000027157
InParanoidiP0ACS7
OMAiNYAESPI
PhylomeDBiP0ACS7

Family and domain databases

CDDicd05013 SIS_RpiR, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR000281 HTH_RpiR
IPR035472 RpiR-like_SIS
IPR001347 SIS
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF01418 HTH_6, 1 hit
PF01380 SIS, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51071 HTH_RPIR, 1 hit
PS51464 SIS, 1 hit

Sequencei

Sequence statusi: Complete.

P0ACS7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQSEFDSAL PNGIGLAPYL RMKQEGMTEN ESRIVEWLLK PGNLSCAPAI
60 70 80 90 100
KDVAEALAVS EAMIVKVSKL LGFSGFRNLR SALEDYFSQS EQVLPSELAF
110 120 130 140 150
DEAPQDVVNK VFNITLRTIM EGQSIVNVDE IHRAARFFYQ ARQRDLYGAG
160 170 180 190 200
GSNAICADVQ HKFLRIGVRC QAYPDAHIMM MSASLLQEGD VVLVVTHSGR
210 220 230 240 250
TSDVKAAVEL AKKNGAKIIC ITHSYHSPIA KLADYIICSP APETPLLGRN
260 270 280 290
ASARILQLTL LDAFFVSVAQ LNIEQANINM QKTGAIVDFF SPGALK
Length:296
Mass (Da):32,362
Last modified:November 22, 2005 - v1
Checksum:i7946848F0798E200
GO

Sequence cautioni

The sequence AAA96988 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82203 Genomic DNA Translation: CAA57687.1
U14003 Genomic DNA Translation: AAA96988.1 Different initiation.
U00096 Genomic DNA Translation: AAC77050.2
AP009048 Genomic DNA Translation: BAE78092.1
PIRiS56317
RefSeqiNP_418513.4, NC_000913.3
WP_000083216.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77050; AAC77050; b4089
BAE78092; BAE78092; BAE78092
GeneIDi948603
KEGGiecj:JW4050
eco:b4089
PATRICifig|511145.12.peg.4216

Similar proteinsi

Entry informationi

Entry nameiRPIR_ECOLI
AccessioniPrimary (citable) accession number: P0ACS7
Secondary accession number(s): P39266, P76791, Q2M6L4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: September 12, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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