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Protein

Redox-sensitive transcriptional activator SoxR

Gene

soxR

Organism
Shigella flexneri
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron-sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster is employed in vivo to modulate the transcriptional activity of SoxR in response to specific types of oxidative stress. Upon reduction of 2Fe-2S cluster, SoxR reversibly loses its transcriptional activity, but retains its DNA binding affinity (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi119Iron-sulfur (2Fe-2S)By similarity1
Metal bindingi122Iron-sulfur (2Fe-2S)By similarity1
Metal bindingi124Iron-sulfur (2Fe-2S)By similarity1
Metal bindingi130Iron-sulfur (2Fe-2S)By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi14 – 33H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
Ligand2Fe-2S, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Redox-sensitive transcriptional activator SoxR
Gene namesi
Name:soxR
Ordered Locus Names:SF4123, S3590
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000981541 – 154Redox-sensitive transcriptional activator SoxRAdd BLAST154

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP0ACS4
SMRiP0ACS4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 79HTH merR-typePROSITE-ProRule annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni119 – 130Might be part of a sensor regionBy similarityAdd BLAST12

Phylogenomic databases

eggNOGiENOG4108Z4X Bacteria
COG0789 LUCA
HOGENOMiHOG000266085
KOiK13639
OMAiNGNQRRY

Family and domain databases

CDDicd01110 HTH_SoxR, 1 hit
InterProiView protein in InterPro
IPR009061 DNA-bd_dom_put_sf
IPR000551 MerR-type_HTH_dom
IPR010211 Redox-sen_tscrpt-act_SoxR
IPR015358 Tscrpt_reg_MerR_DNA-bd
PANTHERiPTHR30204:SF0 PTHR30204:SF0, 1 hit
PfamiView protein in Pfam
PF00376 MerR, 1 hit
PF09278 MerR-DNA-bind, 1 hit
PRINTSiPR00040 HTHMERR
SMARTiView protein in SMART
SM00422 HTH_MERR, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
TIGRFAMsiTIGR01950 SoxR, 1 hit
PROSITEiView protein in PROSITE
PS00552 HTH_MERR_1, 1 hit
PS50937 HTH_MERR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0ACS4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKKLPRIKA LLTPGEVAKR SGVAVSALHF YESKGLITSI RNSGNQRRYK
60 70 80 90 100
RDVLRYVAII KIAQRIGIPL ATIGEAFGVL PEGHTLSAKE WKQLSSQWRE
110 120 130 140 150
ELDRRIHTLV ALRDELDGCI GCGCLSRSDC PLRNPGDRLG EEGTGARLLE

DEQN
Length:154
Mass (Da):17,150
Last modified:November 22, 2005 - v1
Checksum:i9A715120860EEC9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA Translation: AAN45547.1
AE014073 Genomic DNA Translation: AAP18635.1
RefSeqiNP_709840.1, NC_004337.2
WP_000412428.1, NZ_PUHH01000144.1

Genome annotation databases

EnsemblBacteriaiAAN45547; AAN45547; SF4123
AAP18635; AAP18635; S3590
GeneIDi1026084
KEGGisfl:SF4123
sfx:S3590
PATRICifig|198214.7.peg.4862

Similar proteinsi

Entry informationi

Entry nameiSOXR_SHIFL
AccessioniPrimary (citable) accession number: P0ACS4
Secondary accession number(s): P22538, Q53442
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: July 18, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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