UniProtKB - P0ACN7 (CYTR_ECOLI)
Protein
HTH-type transcriptional repressor CytR
Gene
cytR
Organism
Escherichia coli (strain K12)
Status
Functioni
This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 12 – 31 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 20 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: GO_Central
- transcription regulatory region sequence-specific DNA binding Source: EcoCyc
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: EcoCyc
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
BioCyci | EcoCyc:PD04028 |
Names & Taxonomyi
Protein namesi | Recommended name: HTH-type transcriptional repressor CytR |
Gene namesi | Name:cytR Ordered Locus Names:b3934, JW3905 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000107938 | 1 – 341 | HTH-type transcriptional repressor CytRAdd BLAST | 341 |
Proteomic databases
jPOSTi | P0ACN7 |
PaxDbi | P0ACN7 |
PRIDEi | P0ACN7 |
Interactioni
Binary interactionsi
P0ACN7
With | #Exp. | IntAct |
---|---|---|
manX [P69797] | 2 | EBI-1125696,EBI-554089 |
Protein-protein interaction databases
BioGRIDi | 4262650, 18 interactors 852724, 5 interactors |
DIPi | DIP-9390N |
IntActi | P0ACN7, 6 interactors |
STRINGi | 511145.b3934 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P0ACN7 |
SMRi | P0ACN7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P0ACN7 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 10 – 64 | HTH lacI-typePROSITE-ProRule annotationAdd BLAST | 55 |
Phylogenomic databases
eggNOGi | COG1609, Bacteria |
HOGENOMi | CLU_037628_6_0_6 |
InParanoidi | P0ACN7 |
PhylomeDBi | P0ACN7 |
Family and domain databases
CDDi | cd01392, HTH_LacI, 1 hit |
Gene3Di | 1.10.260.40, 1 hit |
InterProi | View protein in InterPro IPR000843, HTH_LacI IPR010982, Lambda_DNA-bd_dom_sf IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF00356, LacI, 1 hit |
SMARTi | View protein in SMART SM00354, HTH_LACI, 1 hit |
SUPFAMi | SSF47413, SSF47413, 1 hit SSF53822, SSF53822, 1 hit |
PROSITEi | View protein in PROSITE PS00356, HTH_LACI_1, 1 hit PS50932, HTH_LACI_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P0ACN7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKAKKQETAA TMKDVALKAK VSTATVSRAL MNPDKVSQAT RNRVEKAARE
60 70 80 90 100
VGYLPQPMGR NVKRNESRTI LVIVPDICDP FFSEIIRGIE VTAANHGYLV
110 120 130 140 150
LIGDCAHQNQ QEKTFIDLII TKQIDGMLLL GSRLPFDASI EEQRNLPPMV
160 170 180 190 200
MANEFAPELE LPTVHIDNLT AAFDAVNYLY EQGHKRIGCI AGPEEMPLCH
210 220 230 240 250
YRLQGYVQAL RRCGIMVDPQ YIARGDFTFE AGSKAMQQLL DLPQPPTAVF
260 270 280 290 300
CHSDVMALGA LSQAKRQGLK VPEDLSIIGF DNIDLTQFCD PPLTTIAQPR
310 320 330 340
YEIGREAMLL LLDQMQGQHV GSGSRLMDCE LIIRGSTRAL P
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X03683 Genomic DNA Translation: CAA27318.1 L19201 Genomic DNA Translation: AAB03066.1 U00096 Genomic DNA Translation: AAC76916.1 AP009048 Genomic DNA Translation: BAE77376.1 M33293 Genomic DNA Translation: AAA24417.1 |
PIRi | A24963, RPECCT |
RefSeqi | NP_418369.1, NC_000913.3 WP_000644904.1, NZ_STEB01000017.1 |
Genome annotation databases
EnsemblBacteriai | AAC76916; AAC76916; b3934 BAE77376; BAE77376; BAE77376 |
GeneIDi | 57732225 948427 |
KEGGi | ecj:JW3905 eco:b3934 |
PATRICi | fig|1411691.4.peg.2771 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X03683 Genomic DNA Translation: CAA27318.1 L19201 Genomic DNA Translation: AAB03066.1 U00096 Genomic DNA Translation: AAC76916.1 AP009048 Genomic DNA Translation: BAE77376.1 M33293 Genomic DNA Translation: AAA24417.1 |
PIRi | A24963, RPECCT |
RefSeqi | NP_418369.1, NC_000913.3 WP_000644904.1, NZ_STEB01000017.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2LCV | NMR | - | A | 1-67 | [»] | |
BMRBi | P0ACN7 | |||||
SMRi | P0ACN7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4262650, 18 interactors 852724, 5 interactors |
DIPi | DIP-9390N |
IntActi | P0ACN7, 6 interactors |
STRINGi | 511145.b3934 |
Proteomic databases
jPOSTi | P0ACN7 |
PaxDbi | P0ACN7 |
PRIDEi | P0ACN7 |
Genome annotation databases
EnsemblBacteriai | AAC76916; AAC76916; b3934 BAE77376; BAE77376; BAE77376 |
GeneIDi | 57732225 948427 |
KEGGi | ecj:JW3905 eco:b3934 |
PATRICi | fig|1411691.4.peg.2771 |
Organism-specific databases
EchoBASEi | EB0196 |
Phylogenomic databases
eggNOGi | COG1609, Bacteria |
HOGENOMi | CLU_037628_6_0_6 |
InParanoidi | P0ACN7 |
PhylomeDBi | P0ACN7 |
Enzyme and pathway databases
BioCyci | EcoCyc:PD04028 |
Miscellaneous databases
EvolutionaryTracei | P0ACN7 |
PROi | PR:P0ACN7 |
Family and domain databases
CDDi | cd01392, HTH_LacI, 1 hit |
Gene3Di | 1.10.260.40, 1 hit |
InterProi | View protein in InterPro IPR000843, HTH_LacI IPR010982, Lambda_DNA-bd_dom_sf IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF00356, LacI, 1 hit |
SMARTi | View protein in SMART SM00354, HTH_LACI, 1 hit |
SUPFAMi | SSF47413, SSF47413, 1 hit SSF53822, SSF53822, 1 hit |
PROSITEi | View protein in PROSITE PS00356, HTH_LACI_1, 1 hit PS50932, HTH_LACI_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CYTR_ECOLI | |
Accessioni | P0ACN7Primary (citable) accession number: P0ACN7 Secondary accession number(s): P06964, Q2M8N0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1988 |
Last sequence update: | April 1, 1988 | |
Last modified: | April 7, 2021 | |
This is version 113 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references