UniProtKB - P0ACL9 (PDHR_ECOLI)
Protein
Pyruvate dehydrogenase complex repressor
Gene
pdhR
Organism
Escherichia coli (strain K12)
Status
Functioni
Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 37 – 56 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 20 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: EcoCyc
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: EcoCyc
- positive regulation of transcription, DNA-templated Source: EcoCyc
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11088-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Pyruvate dehydrogenase complex repressor |
Gene namesi | Name:pdhR Synonyms:aceC, genA, yacB Ordered Locus Names:b0113, JW0109 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050662 | 1 – 254 | Pyruvate dehydrogenase complex repressorAdd BLAST | 254 |
Proteomic databases
jPOSTi | P0ACL9 |
PaxDbi | P0ACL9 |
PRIDEi | P0ACL9 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260661, 9 interactors 849227, 1 interactor |
IntActi | P0ACL9, 8 interactors |
STRINGi | 511145.b0113 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0ACL9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 77 | HTH gntR-typePROSITE-ProRule annotationAdd BLAST | 69 |
Phylogenomic databases
eggNOGi | COG2186, Bacteria |
HOGENOMi | CLU_017584_9_5_6 |
InParanoidi | P0ACL9 |
PhylomeDBi | P0ACL9 |
Family and domain databases
CDDi | cd07377, WHTH_GntR, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 1.20.120.530, 1 hit |
InterProi | View protein in InterPro IPR011711, GntR_C IPR008920, TF_FadR/GntR_C IPR000524, Tscrpt_reg_HTH_GntR IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF07729, FCD, 1 hit PF00392, GntR, 1 hit |
PRINTSi | PR00035, HTHGNTR |
SMARTi | View protein in SMART SM00895, FCD, 1 hit SM00345, HTH_GNTR, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF48008, SSF48008, 1 hit |
PROSITEi | View protein in PROSITE PS50949, HTH_GNTR, 1 hit |
i Sequence
Sequence statusi: Complete.
P0ACL9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAYSKIRQPK LSDVIEQQLE FLILEGTLRP GEKLPPEREL AKQFDVSRPS
60 70 80 90 100
LREAIQRLEA KGLLLRRQGG GTFVQSSLWQ SFSDPLVELL SDHPESQYDL
110 120 130 140 150
LETRHALEGI AAYYAALRST DEDKERIREL HHAIELAQQS GDLDAESNAV
160 170 180 190 200
LQYQIAVTEA AHNVVLLHLL RCMEPMLAQN VRQNFELLYS RREMLPLVSS
210 220 230 240 250
HRTRIFEAIM AGKPEEAREA SHRHLAFIEE ILLDRSREES RRERSLRRLE
QRKN
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 118 | R → C in ACEC816; constitutively activated. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V01498 Genomic DNA Translation: CAA24739.1 U00096 Genomic DNA Translation: AAC73224.1 AP009048 Genomic DNA Translation: BAB96683.2 S67363 Genomic DNA Translation: AAB29356.1 |
PIRi | A64734, BVECA |
RefSeqi | NP_414655.1, NC_000913.3 WP_000331776.1, NZ_STEB01000010.1 |
Genome annotation databases
EnsemblBacteriai | AAC73224; AAC73224; b0113 BAB96683; BAB96683; BAB96683 |
GeneIDi | 58461989 944827 |
KEGGi | ecj:JW0109 eco:b0113 |
PATRICi | fig|1411691.4.peg.2169 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V01498 Genomic DNA Translation: CAA24739.1 U00096 Genomic DNA Translation: AAC73224.1 AP009048 Genomic DNA Translation: BAB96683.2 S67363 Genomic DNA Translation: AAB29356.1 |
PIRi | A64734, BVECA |
RefSeqi | NP_414655.1, NC_000913.3 WP_000331776.1, NZ_STEB01000010.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5KVR | X-ray | 1.36 | A | 1-75 | [»] | |
5TPM | X-ray | 2.80 | A/B/C/D | 99-254 | [»] | |
SMRi | P0ACL9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4260661, 9 interactors 849227, 1 interactor |
IntActi | P0ACL9, 8 interactors |
STRINGi | 511145.b0113 |
Proteomic databases
jPOSTi | P0ACL9 |
PaxDbi | P0ACL9 |
PRIDEi | P0ACL9 |
Genome annotation databases
EnsemblBacteriai | AAC73224; AAC73224; b0113 BAB96683; BAB96683; BAB96683 |
GeneIDi | 58461989 944827 |
KEGGi | ecj:JW0109 eco:b0113 |
PATRICi | fig|1411691.4.peg.2169 |
Organism-specific databases
EchoBASEi | EB1080 |
Phylogenomic databases
eggNOGi | COG2186, Bacteria |
HOGENOMi | CLU_017584_9_5_6 |
InParanoidi | P0ACL9 |
PhylomeDBi | P0ACL9 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11088-MONOMER |
Miscellaneous databases
PROi | PR:P0ACL9 |
Gene expression databases
CollecTFi | EXPREG_00000860 |
Family and domain databases
CDDi | cd07377, WHTH_GntR, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 1.20.120.530, 1 hit |
InterProi | View protein in InterPro IPR011711, GntR_C IPR008920, TF_FadR/GntR_C IPR000524, Tscrpt_reg_HTH_GntR IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF07729, FCD, 1 hit PF00392, GntR, 1 hit |
PRINTSi | PR00035, HTHGNTR |
SMARTi | View protein in SMART SM00895, FCD, 1 hit SM00345, HTH_GNTR, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF48008, SSF48008, 1 hit |
PROSITEi | View protein in PROSITE PS50949, HTH_GNTR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PDHR_ECOLI | |
Accessioni | P0ACL9Primary (citable) accession number: P0ACL9 Secondary accession number(s): P06957, Q53381, Q8KMZ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1988 |
Last sequence update: | November 22, 2005 | |
Last modified: | April 7, 2021 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references