UniProtKB - P0ACL2 (EXUR_ECOLI)
Protein
Exu regulon transcriptional regulator
Gene
exuR
Organism
Escherichia coli (strain K12)
Status
Functioni
Repressor for the exu regulon that encode genes involved in hexuronate utilization. It regulates the ExuT, UxaCA and UxuRAB operons. Binds D-tagaturonate and D-fructuronate as inducers.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 35 – 54 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 20 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: InterPro
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: EcoCyc
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
BioCyci | EcoCyc:PD03270 |
Names & Taxonomyi
Protein namesi | Recommended name: Exu regulon transcriptional regulator |
Gene namesi | Name:exuR Ordered Locus Names:b3094, JW3065 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050622 | 1 – 258 | Exu regulon transcriptional regulatorAdd BLAST | 258 |
Proteomic databases
jPOSTi | P0ACL2 |
PaxDbi | P0ACL2 |
PRIDEi | P0ACL2 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4262410, 10 interactors |
IntActi | P0ACL2, 3 interactors |
STRINGi | 511145.b3094 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 75 | HTH gntR-typePROSITE-ProRule annotationAdd BLAST | 69 |
Phylogenomic databases
eggNOGi | COG2186, Bacteria |
HOGENOMi | CLU_017584_9_5_6 |
InParanoidi | P0ACL2 |
PhylomeDBi | P0ACL2 |
Family and domain databases
CDDi | cd07377, WHTH_GntR, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 1.20.120.530, 1 hit |
InterProi | View protein in InterPro IPR011711, GntR_C IPR008920, TF_FadR/GntR_C IPR000524, Tscrpt_reg_HTH_GntR IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF07729, FCD, 1 hit PF00392, GntR, 1 hit |
PRINTSi | PR00035, HTHGNTR |
SMARTi | View protein in SMART SM00895, FCD, 1 hit SM00345, HTH_GNTR, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF48008, SSF48008, 1 hit |
PROSITEi | View protein in PROSITE PS50949, HTH_GNTR, 1 hit |
i Sequence
Sequence statusi: Complete.
P0ACL2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEITEPRRLY QQLAADLKER IEQGVYLVGD KLPAERFIAD EKNVSRTVVR
60 70 80 90 100
EAIIMLEVEG YVEVRKGSGI HVVSNQPRHQ QAADNNMEFA NYGPFELLQA
110 120 130 140 150
RQLIESNIAE FAATQVTKQD IMKLMAIQEQ ARGEQCFRDS EWDLQFHIQV
160 170 180 190 200
ALATQNSALA AIVEKMWTQR SHNPYWKKLH EHIDSRTVDN WCDDHDQILK
210 220 230 240 250
ALIRKDPHAA KLAMWQHLEN TKIMLFNETS DDFEFNADRY LFAENPVVHL
DTATSGSK
Sequence cautioni
The sequence AAA57898 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D13328 Genomic DNA Translation: BAA02589.1 U18997 Genomic DNA Translation: AAA57898.1 Different initiation. U00096 Genomic DNA Translation: AAC76129.2 AP009048 Genomic DNA Translation: BAE77144.1 |
PIRi | C65098 |
RefSeqi | NP_417565.2, NC_000913.3 WP_000406488.1, NZ_STEB01000001.1 |
Genome annotation databases
EnsemblBacteriai | AAC76129; AAC76129; b3094 BAE77144; BAE77144; BAE77144 |
GeneIDi | 48134239 947602 |
KEGGi | ecj:JW3065 eco:b3094 |
PATRICi | fig|511145.12.peg.3189 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D13328 Genomic DNA Translation: BAA02589.1 U18997 Genomic DNA Translation: AAA57898.1 Different initiation. U00096 Genomic DNA Translation: AAC76129.2 AP009048 Genomic DNA Translation: BAE77144.1 |
PIRi | C65098 |
RefSeqi | NP_417565.2, NC_000913.3 WP_000406488.1, NZ_STEB01000001.1 |
3D structure databases
SMRi | P0ACL2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4262410, 10 interactors |
IntActi | P0ACL2, 3 interactors |
STRINGi | 511145.b3094 |
Proteomic databases
jPOSTi | P0ACL2 |
PaxDbi | P0ACL2 |
PRIDEi | P0ACL2 |
Genome annotation databases
EnsemblBacteriai | AAC76129; AAC76129; b3094 BAE77144; BAE77144; BAE77144 |
GeneIDi | 48134239 947602 |
KEGGi | ecj:JW3065 eco:b3094 |
PATRICi | fig|511145.12.peg.3189 |
Organism-specific databases
EchoBASEi | EB2595 |
Phylogenomic databases
eggNOGi | COG2186, Bacteria |
HOGENOMi | CLU_017584_9_5_6 |
InParanoidi | P0ACL2 |
PhylomeDBi | P0ACL2 |
Enzyme and pathway databases
BioCyci | EcoCyc:PD03270 |
Miscellaneous databases
PROi | PR:P0ACL2 |
Family and domain databases
CDDi | cd07377, WHTH_GntR, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 1.20.120.530, 1 hit |
InterProi | View protein in InterPro IPR011711, GntR_C IPR008920, TF_FadR/GntR_C IPR000524, Tscrpt_reg_HTH_GntR IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF07729, FCD, 1 hit PF00392, GntR, 1 hit |
PRINTSi | PR00035, HTHGNTR |
SMARTi | View protein in SMART SM00895, FCD, 1 hit SM00345, HTH_GNTR, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF48008, SSF48008, 1 hit |
PROSITEi | View protein in PROSITE PS50949, HTH_GNTR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EXUR_ECOLI | |
Accessioni | P0ACL2Primary (citable) accession number: P0ACL2 Secondary accession number(s): P42608 Q8X4Y9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2005 |
Last sequence update: | November 22, 2005 | |
Last modified: | December 2, 2020 | |
This is version 109 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |