UniProtKB - P0ACB0 (DNAB_ECOLI)
Protein
Replicative DNA helicase
Gene
dnaB
Organism
Escherichia coli (strain K12)
Status
Functioni
Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.
Catalytic activityi
- EC:3.6.4.12
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 231 – 238 | ATPCurated | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- DNA binding Source: UniProtKB-KW
- DNA helicase activity Source: EcoCyc
- helicase activity Source: EcoCyc
- identical protein binding Source: IntAct
GO - Biological processi
- DNA replication Source: EcoCyc
- DNA replication, synthesis of RNA primer Source: UniProtKB-KW
- DNA unwinding involved in DNA replication Source: EcoCyc
- response to ionizing radiation Source: EcoCyc
Keywordsi
Molecular function | DNA-binding, Helicase, Hydrolase |
Biological process | DNA replication |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10236-MONOMER ECOL316407:JW4012-MONOMER MetaCyc:EG10236-MONOMER |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:dnaB Synonyms:groP, grpA Ordered Locus Names:b4052, JW4012 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
GO - Cellular componenti
- cytosol Source: EcoCyc
- primosome complex Source: UniProtKB-KW
Keywords - Cellular componenti
PrimosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000102019 | 1 – 471 | Replicative DNA helicaseAdd BLAST | 471 |
Proteomic databases
EPDi | P0ACB0 |
jPOSTi | P0ACB0 |
PaxDbi | P0ACB0 |
PRIDEi | P0ACB0 |
2D gel databases
SWISS-2DPAGEi | P0ACB0 |
Expressioni
Inductioni
Slightly induced by hydroxyurea.1 Publication
Interactioni
Subunit structurei
Homohexamer.
Binary interactionsi
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGridi | 4261652, 171 interactors 852849, 4 interactors |
ComplexPortali | CPX-1933 DnaB-DnaG complex CPX-1934 DnaB-DnaC complex CPX-1935 DnaA-DnaB complex CPX-1946 DnaB helicase complex CPX-1950 DnaA-DnaB-DnaC complex CPX-1951 DnaB-DnaC-DnaT-PriA-PriB complex CPX-1952 DnaB-DnaC-DnaT-PriA-PriC complex CPX-1953 DnaB-DnaC-Rep-PriC complex |
DIPi | DIP-9456N |
IntActi | P0ACB0, 39 interactors |
MINTi | P0ACB0 |
STRINGi | 511145.b4052 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0ACB0 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P0ACB0 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 200 – 467 | SF4 helicasePROSITE-ProRule annotationAdd BLAST | 268 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG4105CDU Bacteria COG0305 LUCA |
HOGENOMi | HOG000113196 |
InParanoidi | P0ACB0 |
KOi | K02314 |
PhylomeDBi | P0ACB0 |
Family and domain databases
CDDi | cd00984 DnaB_C, 1 hit |
Gene3Di | 1.10.860.10, 1 hit |
InterProi | View protein in InterPro IPR003593 AAA+_ATPase IPR036185 DNA_heli_DnaB-like_N_sf IPR007692 DNA_helicase_DnaB IPR007694 DNA_helicase_DnaB-like_C IPR007693 DNA_helicase_DnaB-like_N IPR016136 DNA_helicase_N/primase_C IPR027417 P-loop_NTPase |
Pfami | View protein in Pfam PF00772 DnaB, 1 hit PF03796 DnaB_C, 1 hit |
SMARTi | View protein in SMART SM00382 AAA, 1 hit |
SUPFAMi | SSF48024 SSF48024, 1 hit SSF52540 SSF52540, 1 hit |
TIGRFAMsi | TIGR00665 DnaB, 1 hit |
PROSITEi | View protein in PROSITE PS51199 SF4_HELICASE, 1 hit |
i Sequence
Sequence statusi: Complete.
P0ACB0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGNKPFNKQ QAEPRERDPQ VAGLKVPPHS IEAEQSVLGG LMLDNERWDD
60 70 80 90 100
VAERVVADDF YTRPHRHIFT EMARLQESGS PIDLITLAES LERQGQLDSV
110 120 130 140 150
GGFAYLAELS KNTPSAANIS AYADIVRERA VVREMISVAN EIAEAGFDPQ
160 170 180 190 200
GRTSEDLLDL AESRVFKIAE SRANKDEGPK NIADVLDATV ARIEQLFQQP
210 220 230 240 250
HDGVTGVNTG YDDLNKKTAG LQPSDLIIVA ARPSMGKTTF AMNLVENAAM
260 270 280 290 300
LQDKPVLIFS LEMPSEQIMM RSLASLSRVD QTKIRTGQLD DEDWARISGT
310 320 330 340 350
MGILLEKRNI YIDDSSGLTP TEVRSRARRI AREHGGIGLI MIDYLQLMRV
360 370 380 390 400
PALSDNRTLE IAEISRSLKA LAKELNVPVV ALSQLNRSLE QRADKRPVNS
410 420 430 440 450
DLRESGSIEQ DADLIMFIYR DEVYHENSDL KGIAEIIIGK QRNGPIGTVR
460 470
LTFNGQWSRF DNYAGPQYDD E
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K01174 Genomic DNA Translation: AAA23689.1 L02312 Genomic DNA Translation: AAA23690.1 U00006 Genomic DNA Translation: AAC43146.1 U00096 Genomic DNA Translation: AAC77022.1 AP009048 Genomic DNA Translation: BAE78054.1 |
PIRi | C65213 IQECDB |
RefSeqi | NP_418476.1, NC_000913.3 WP_000918363.1, NZ_STEB01000022.1 |
Genome annotation databases
EnsemblBacteriai | AAC77022; AAC77022; b4052 BAE78054; BAE78054; BAE78054 |
GeneIDi | 948555 |
KEGGi | ecj:JW4012 eco:b4052 |
PATRICi | fig|1411691.4.peg.2655 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K01174 Genomic DNA Translation: AAA23689.1 L02312 Genomic DNA Translation: AAA23690.1 U00006 Genomic DNA Translation: AAC43146.1 U00096 Genomic DNA Translation: AAC77022.1 AP009048 Genomic DNA Translation: BAE78054.1 |
PIRi | C65213 IQECDB |
RefSeqi | NP_418476.1, NC_000913.3 WP_000918363.1, NZ_STEB01000022.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1B79 | X-ray | 2.30 | A/B/C/D | 16-129 | [»] | |
1JWE | NMR | - | A | 24-137 | [»] | |
6BBM | electron microscopy | 4.10 | A/B/C/D/E/F | 1-471 | [»] | |
6QEL | electron microscopy | 3.90 | A/B/C/D/E/F | 1-471 | [»] | |
6QEM | electron microscopy | 3.40 | A/B/C/D/E/F | 1-471 | [»] | |
SMRi | P0ACB0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGridi | 4261652, 171 interactors 852849, 4 interactors |
ComplexPortali | CPX-1933 DnaB-DnaG complex CPX-1934 DnaB-DnaC complex CPX-1935 DnaA-DnaB complex CPX-1946 DnaB helicase complex CPX-1950 DnaA-DnaB-DnaC complex CPX-1951 DnaB-DnaC-DnaT-PriA-PriB complex CPX-1952 DnaB-DnaC-DnaT-PriA-PriC complex CPX-1953 DnaB-DnaC-Rep-PriC complex |
DIPi | DIP-9456N |
IntActi | P0ACB0, 39 interactors |
MINTi | P0ACB0 |
STRINGi | 511145.b4052 |
2D gel databases
SWISS-2DPAGEi | P0ACB0 |
Proteomic databases
EPDi | P0ACB0 |
jPOSTi | P0ACB0 |
PaxDbi | P0ACB0 |
PRIDEi | P0ACB0 |
Genome annotation databases
EnsemblBacteriai | AAC77022; AAC77022; b4052 BAE78054; BAE78054; BAE78054 |
GeneIDi | 948555 |
KEGGi | ecj:JW4012 eco:b4052 |
PATRICi | fig|1411691.4.peg.2655 |
Organism-specific databases
EchoBASEi | EB0232 |
Phylogenomic databases
eggNOGi | ENOG4105CDU Bacteria COG0305 LUCA |
HOGENOMi | HOG000113196 |
InParanoidi | P0ACB0 |
KOi | K02314 |
PhylomeDBi | P0ACB0 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10236-MONOMER ECOL316407:JW4012-MONOMER MetaCyc:EG10236-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P0ACB0 |
PROi | PR:P0ACB0 |
Family and domain databases
CDDi | cd00984 DnaB_C, 1 hit |
Gene3Di | 1.10.860.10, 1 hit |
InterProi | View protein in InterPro IPR003593 AAA+_ATPase IPR036185 DNA_heli_DnaB-like_N_sf IPR007692 DNA_helicase_DnaB IPR007694 DNA_helicase_DnaB-like_C IPR007693 DNA_helicase_DnaB-like_N IPR016136 DNA_helicase_N/primase_C IPR027417 P-loop_NTPase |
Pfami | View protein in Pfam PF00772 DnaB, 1 hit PF03796 DnaB_C, 1 hit |
SMARTi | View protein in SMART SM00382 AAA, 1 hit |
SUPFAMi | SSF48024 SSF48024, 1 hit SSF52540 SSF52540, 1 hit |
TIGRFAMsi | TIGR00665 DnaB, 1 hit |
PROSITEi | View protein in PROSITE PS51199 SF4_HELICASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DNAB_ECOLI | |
Accessioni | P0ACB0Primary (citable) accession number: P0ACB0 Secondary accession number(s): P03005, Q2M6Q2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | August 13, 1987 | |
Last modified: | November 13, 2019 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene - PDB cross-references
Index of Protein Data Bank (PDB) cross-references