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Entry version 111 (02 Dec 2020)
Sequence version 1 (08 Nov 2005)
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Protein

Glycogen phosphorylase

Gene

glgP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pyridoxal 5'-phosphate

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAllosteric enzyme, Glycosyltransferase, Transferase
Biological processCarbohydrate metabolism, Glycogen metabolism
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:GLYCOPHOSPHORYL-MONOMER
MetaCyc:GLYCOPHOSPHORYL-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glycogen phosphorylase (EC:2.4.1.1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:glgP
Synonyms:glgY
Ordered Locus Names:b3428, JW3391
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001885531 – 815Glycogen phosphorylaseAdd BLAST815

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei662N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P0AC86

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0AC86

PRoteomics IDEntifications database

More...
PRIDEi
P0AC86

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4261263, 32 interactors

Database of interacting proteins

More...
DIPi
DIP-47899N

Protein interaction database and analysis system

More...
IntActi
P0AC86, 2 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b3428

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0AC86

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycogen phosphorylase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0058, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010198_1_1_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0AC86

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0AC86

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011833, Glycg_phsphrylas
IPR000811, Glyco_trans_35
IPR035090, Pyridoxal_P_attach_site

The PANTHER Classification System

More...
PANTHERi
PTHR11468, PTHR11468, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00343, Phosphorylase, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000460, Pprylas_GlgP, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02093, P_ylase, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00102, PHOSPHORYLASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0AC86-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNAPFTYSSP TLSVEALKHS IAYKLMFTIG KDPVVANKHE WLNATLFAVR
60 70 80 90 100
DRLVERWLRS NRAQLSQETR QVYYLSMEFL IGRTLSNAML SLGIYEDVQG
110 120 130 140 150
ALEAMGLNLE ELIDEENDPG LGNGGLGRLA ACFLDSLATL GLPGRGYGIR
160 170 180 190 200
YDYGMFKQNI VNGSQKESPD YWLEYGNPWE FKRHNTRYKV RFGGRIQQEG
210 220 230 240 250
KKTRWIETEE ILGVAYDQII PGYDTDATNT LRLWSAQASS EINLGKFNQG
260 270 280 290 300
DYFAAVEDKN HSENVSRVLY PDDSTYSGRE LRLRQEYFLV SSTIQDILSR
310 320 330 340 350
HYQLHKTYDN LADKIAIHLN DTHPVLSIPE MMRLLIDEHQ FSWDDAFEVC
360 370 380 390 400
CQVFSYTNHT LMSEALETWP VDMLGKILPR HLQIIFEIND YFLKTLQEQY
410 420 430 440 450
PNDTDLLGRA SIIDESNGRR VRMAWLAVVV SHKVNGVSEL HSNLMVQSLF
460 470 480 490 500
ADFAKIFPGR FTNVTNGVTP RRWLAVANPS LSAVLDEHLG RNWRTDLSLL
510 520 530 540 550
NELQQHCDFP MVNHAVHQAK LENKKRLAEY IAQQLNVVVN PKALFDVQIK
560 570 580 590 600
RIHEYKRQLM NVLHVITRYN RIKADPDAKW VPRVNIFGGK AASAYYMAKH
610 620 630 640 650
IIHLINDVAK VINNDPQIGD KLKVVFIPNY SVSLAQLIIP AADLSEQISL
660 670 680 690 700
AGTEASGTSN MKFALNGALT IGTLDGANVE MLDHVGADNI FIFGNTAEEV
710 720 730 740 750
EELRRQGYKP REYYEKDEEL HQVLTQIGSG VFSPEDPGRY RDLVDSLINF
760 770 780 790 800
GDHYQVLADY RSYVDCQDKV DELYELQEEW TAKAMLNIAN MGYFSSDRTI
810
KEYADHIWHI DPVRL
Length:815
Mass (Da):93,173
Last modified:November 8, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB8046B91D8D7B468
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA34807 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti13 – 14SV → RL (PubMed:2645169).Curated2
Sequence conflicti60S → P in AAA23875 (PubMed:2975249).Curated1
Sequence conflicti94 – 95IY → TH in AAA23875 (PubMed:2975249).Curated2
Sequence conflicti142L → W in AAA23875 (PubMed:2975249).Curated1
Sequence conflicti175Y → S in CAA34807 (PubMed:2645169).Curated1
Sequence conflicti182 – 187Missing in AAA23874 (PubMed:3047129).Curated6
Sequence conflicti191R → V in CAA34807 (PubMed:2645169).Curated1
Sequence conflicti248N → D in AAA23875 (PubMed:2975249).Curated1
Sequence conflicti280 – 281EL → DV in AAA23874 (PubMed:3047129).Curated2
Sequence conflicti280 – 281EL → DV in AAA58226 (PubMed:3047129).Curated2
Sequence conflicti280E → G in AAA23875 (PubMed:2975249).Curated1
Sequence conflicti324P → S in AAA23875 (PubMed:2975249).Curated1
Sequence conflicti377I → S in AAA23875 (PubMed:2975249).Curated1
Sequence conflicti450F → L in AAA23874 (PubMed:3047129).Curated1
Sequence conflicti487 – 488EH → GT in CAA34807 (PubMed:2645169).Curated2
Sequence conflicti520 – 521KL → NV in CAA34807 (PubMed:2645169).Curated2
Sequence conflicti729S → T in AAA23874 (PubMed:3047129).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X16931 Genomic DNA Translation: CAA34807.1 Frameshift.
J03966 Genomic DNA Translation: AAA23874.1
U18997 Genomic DNA Translation: AAA58226.1 Sequence problems.
U00096 Genomic DNA Translation: AAC76453.1
AP009048 Genomic DNA Translation: BAE77864.1
M22368 Genomic DNA Translation: AAA23875.1
D00425 Genomic DNA Translation: BAA00329.1
J02616 Genomic DNA Translation: AAA23871.1

Protein sequence database of the Protein Information Resource

More...
PIRi
G65138, PHECGG

NCBI Reference Sequences

More...
RefSeqi
NP_417886.1, NC_000913.3
WP_000993449.1, NZ_STEB01000004.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC76453; AAC76453; b3428
BAE77864; BAE77864; BAE77864

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
48727122
947931

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW3391
eco:b3428

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.3300

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16931 Genomic DNA Translation: CAA34807.1 Frameshift.
J03966 Genomic DNA Translation: AAA23874.1
U18997 Genomic DNA Translation: AAA58226.1 Sequence problems.
U00096 Genomic DNA Translation: AAC76453.1
AP009048 Genomic DNA Translation: BAE77864.1
M22368 Genomic DNA Translation: AAA23875.1
D00425 Genomic DNA Translation: BAA00329.1
J02616 Genomic DNA Translation: AAA23871.1
PIRiG65138, PHECGG
RefSeqiNP_417886.1, NC_000913.3
WP_000993449.1, NZ_STEB01000004.1

3D structure databases

SMRiP0AC86
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4261263, 32 interactors
DIPiDIP-47899N
IntActiP0AC86, 2 interactors
STRINGi511145.b3428

Proteomic databases

jPOSTiP0AC86
PaxDbiP0AC86
PRIDEiP0AC86

Genome annotation databases

EnsemblBacteriaiAAC76453; AAC76453; b3428
BAE77864; BAE77864; BAE77864
GeneIDi48727122
947931
KEGGiecj:JW3391
eco:b3428
PATRICifig|1411691.4.peg.3300

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0375

Phylogenomic databases

eggNOGiCOG0058, Bacteria
HOGENOMiCLU_010198_1_1_6
InParanoidiP0AC86
PhylomeDBiP0AC86

Enzyme and pathway databases

BioCyciEcoCyc:GLYCOPHOSPHORYL-MONOMER
MetaCyc:GLYCOPHOSPHORYL-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P0AC86

Family and domain databases

InterProiView protein in InterPro
IPR011833, Glycg_phsphrylas
IPR000811, Glyco_trans_35
IPR035090, Pyridoxal_P_attach_site
PANTHERiPTHR11468, PTHR11468, 1 hit
PfamiView protein in Pfam
PF00343, Phosphorylase, 1 hit
PIRSFiPIRSF000460, Pprylas_GlgP, 1 hit
TIGRFAMsiTIGR02093, P_ylase, 1 hit
PROSITEiView protein in PROSITE
PS00102, PHOSPHORYLASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPHSG_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0AC86
Secondary accession number(s): P13031, Q2M792
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: December 2, 2020
This is version 111 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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