UniProtKB - P0AC65 (NRDH_ECOLI)
Protein
Glutaredoxin-like protein NrdH
Gene
nrdH
Organism
Escherichia coli (strain K12)
Status
Functioni
Electron transport system for the ribonucleotide reductase system NrdEF.
GO - Molecular functioni
- electron transfer activity Source: EcoCyc
- protein disulfide oxidoreductase activity Source: InterPro
GO - Biological processi
- cell redox homeostasis Source: EcoCyc
- positive regulation of oxidoreductase activity Source: EcoCyc
Keywordsi
Biological process | Electron transport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:G7401-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Glutaredoxin-like protein NrdH |
Gene namesi | Name:nrdH Synonyms:ygaN Ordered Locus Names:b2673, JW2648 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000141638 | 1 – 81 | Glutaredoxin-like protein NrdHAdd BLAST | 81 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 11 ↔ 14 | Redox-active |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | P0AC65 |
PRIDEi | P0AC65 |
Expressioni
Inductioni
Induced 2-fold by hydroxyurea.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260693, 13 interactors 851493, 2 interactors |
DIPi | DIP-48164N |
IntActi | P0AC65, 7 interactors |
STRINGi | 511145.b2673 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0AC65 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P0AC65 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 81 | GlutaredoxinPROSITE-ProRule annotationAdd BLAST | 81 |
Sequence similaritiesi
Belongs to the glutaredoxin family.Curated
Keywords - Domaini
Redox-active centerPhylogenomic databases
eggNOGi | COG0695, Bacteria |
HOGENOMi | CLU_026126_9_0_6 |
InParanoidi | P0AC65 |
PhylomeDBi | P0AC65 |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR011909, GlrX_NrdH IPR002109, Glutaredoxin IPR036249, Thioredoxin-like_sf |
Pfami | View protein in Pfam PF00462, Glutaredoxin, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
TIGRFAMsi | TIGR02194, GlrX_NrdH, 1 hit |
PROSITEi | View protein in PROSITE PS51354, GLUTAREDOXIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P0AC65-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRITIYTRND CVQCHATKRA MENRGFDFEM INVDRVPEAA EALRAQGFRQ
60 70 80
LPVVIAGDLS WSGFRPDMIN RLHPAPHAAS A
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X79787 Genomic DNA Translation: CAA56184.1 U00096 Genomic DNA Translation: AAC75720.1 AP009048 Genomic DNA Translation: BAE76782.1 |
PIRi | S70891 |
RefSeqi | NP_417159.1, NC_000913.3 WP_001223227.1, NZ_STEB01000042.1 |
Genome annotation databases
EnsemblBacteriai | AAC75720; AAC75720; b2673 BAE76782; BAE76782; BAE76782 |
GeneIDi | 58389148 947161 |
KEGGi | ecj:JW2648 eco:b2673 |
PATRICi | fig|1411691.4.peg.4068 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X79787 Genomic DNA Translation: CAA56184.1 U00096 Genomic DNA Translation: AAC75720.1 AP009048 Genomic DNA Translation: BAE76782.1 |
PIRi | S70891 |
RefSeqi | NP_417159.1, NC_000913.3 WP_001223227.1, NZ_STEB01000042.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1H75 | X-ray | 1.70 | A | 1-81 | [»] | |
SMRi | P0AC65 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4260693, 13 interactors 851493, 2 interactors |
DIPi | DIP-48164N |
IntActi | P0AC65, 7 interactors |
STRINGi | 511145.b2673 |
Proteomic databases
PaxDbi | P0AC65 |
PRIDEi | P0AC65 |
Genome annotation databases
EnsemblBacteriai | AAC75720; AAC75720; b2673 BAE76782; BAE76782; BAE76782 |
GeneIDi | 58389148 947161 |
KEGGi | ecj:JW2648 eco:b2673 |
PATRICi | fig|1411691.4.peg.4068 |
Organism-specific databases
EchoBASEi | EB3071 |
Phylogenomic databases
eggNOGi | COG0695, Bacteria |
HOGENOMi | CLU_026126_9_0_6 |
InParanoidi | P0AC65 |
PhylomeDBi | P0AC65 |
Enzyme and pathway databases
BioCyci | EcoCyc:G7401-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P0AC65 |
PROi | PR:P0AC65 |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR011909, GlrX_NrdH IPR002109, Glutaredoxin IPR036249, Thioredoxin-like_sf |
Pfami | View protein in Pfam PF00462, Glutaredoxin, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
TIGRFAMsi | TIGR02194, GlrX_NrdH, 1 hit |
PROSITEi | View protein in PROSITE PS51354, GLUTAREDOXIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NRDH_ECOLI | |
Accessioni | P0AC65Primary (citable) accession number: P0AC65 Secondary accession number(s): Q2MAC4, Q47414 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2005 |
Last sequence update: | November 8, 2005 | |
Last modified: | April 7, 2021 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families