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UniProtKB - P0AC35 (TTDB_ECOLI)
Protein
L(+)-tartrate dehydratase subunit beta
Gene
ttdB
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalytic activityi
- EC:4.2.1.321 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 37 | Sequence analysis | 1 |
GO - Molecular functioni
- L(+)-tartrate dehydratase activity Source: UniProtKB-EC
GO - Biological processi
- response to heat Source: EcoCyc
Keywordsi
Molecular function | Lyase |
Enzyme and pathway databases
BioCyci | EcoCyc:TTDB-MONOMER |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ttdB Synonyms:ygjB Ordered Locus Names:b3062, JW3034 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000195664 | 1 – 201 | L(+)-tartrate dehydratase subunit betaAdd BLAST | 201 |
Proteomic databases
PaxDbi | P0AC35 |
PRIDEi | P0AC35 |
Expressioni
Inductioni
Induced by tartrate, via TtdR.1 Publication
Interactioni
Subunit structurei
Heterotetramer of two alpha and two beta subunits.
1 PublicationProtein-protein interaction databases
BioGRIDi | 4261199, 429 interactors |
ComplexPortali | CPX-5912, L-tartrate dehydratase complex |
IntActi | P0AC35, 2 interactors |
STRINGi | 511145.b3062 |
Family & Domainsi
Sequence similaritiesi
Belongs to the class-I fumarase family.Curated
Phylogenomic databases
eggNOGi | COG1838, Bacteria |
HOGENOMi | CLU_098588_0_0_6 |
InParanoidi | P0AC35 |
PhylomeDBi | P0AC35 |
Family and domain databases
Gene3Di | 3.20.130.10, 1 hit |
InterProi | View protein in InterPro IPR004647, Fe-S_hydro-lyase_TtdB-typ_cat IPR036660, Fe-S_hydroAse_TtdB_cat_sf |
Pfami | View protein in Pfam PF05683, Fumerase_C, 1 hit |
SUPFAMi | SSF117457, SSF117457, 1 hit |
TIGRFAMsi | TIGR00723, ttdB_fumA_fumB, 1 hit |
i Sequence
Sequence statusi: Complete.
P0AC35-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKKILTTPIK AEDLQDIRVG DVIYLTGTLV TCRDVCHRRL IELKRPIPYD
60 70 80 90 100
LNGKAIFHAG PIVRKNGDKW EMVSVGPTTS MRMESFEREF IEQTGVKLVV
110 120 130 140 150
GKGGMGPLTE EGCQKFKALH VIFPAGCAVL AATQVEEIEE VHWTELGMPE
160 170 180 190 200
SLWVCRVKEF GPLIVSIDTH GNNLIAENKK LFAERRDPIV EEICEHVHYI
K
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 80 – 85 | SMRMES → QYAYGK (PubMed:8371115).Curated | 6 | |
Sequence conflicti | 80 – 85 | SMRMES → QYAYGK (PubMed:3297921).Curated | 6 | |
Sequence conflicti | 165 | V → A (PubMed:8371115).Curated | 1 | |
Sequence conflicti | 165 | V → A (PubMed:3297921).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L14781 Unassigned DNA Translation: AAA03062.1 M16194 Genomic DNA Translation: AAA72574.1 U28379 Genomic DNA Translation: AAA89142.1 U00096 Genomic DNA Translation: AAC76098.1 AP009048 Genomic DNA Translation: BAE77113.1 |
PIRi | D65094, QQECRZ |
RefSeqi | NP_417534.1, NC_000913.3 WP_000722957.1, NZ_STEB01000001.1 |
Genome annotation databases
EnsemblBacteriai | AAC76098; AAC76098; b3062 BAE77113; BAE77113; BAE77113 |
GeneIDi | 67414991 947568 |
KEGGi | ecj:JW3034 eco:b3062 |
PATRICi | fig|511145.12.peg.3156 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L14781 Unassigned DNA Translation: AAA03062.1 M16194 Genomic DNA Translation: AAA72574.1 U28379 Genomic DNA Translation: AAA89142.1 U00096 Genomic DNA Translation: AAC76098.1 AP009048 Genomic DNA Translation: BAE77113.1 |
PIRi | D65094, QQECRZ |
RefSeqi | NP_417534.1, NC_000913.3 WP_000722957.1, NZ_STEB01000001.1 |
3D structure databases
SMRi | P0AC35 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4261199, 429 interactors |
ComplexPortali | CPX-5912, L-tartrate dehydratase complex |
IntActi | P0AC35, 2 interactors |
STRINGi | 511145.b3062 |
Proteomic databases
PaxDbi | P0AC35 |
PRIDEi | P0AC35 |
Protocols and materials databases
DNASUi | 947568 |
Genome annotation databases
EnsemblBacteriai | AAC76098; AAC76098; b3062 BAE77113; BAE77113; BAE77113 |
GeneIDi | 67414991 947568 |
KEGGi | ecj:JW3034 eco:b3062 |
PATRICi | fig|511145.12.peg.3156 |
Organism-specific databases
EchoBASEi | EB1157 |
Phylogenomic databases
eggNOGi | COG1838, Bacteria |
HOGENOMi | CLU_098588_0_0_6 |
InParanoidi | P0AC35 |
PhylomeDBi | P0AC35 |
Enzyme and pathway databases
BioCyci | EcoCyc:TTDB-MONOMER |
Miscellaneous databases
PROi | PR:P0AC35 |
Family and domain databases
Gene3Di | 3.20.130.10, 1 hit |
InterProi | View protein in InterPro IPR004647, Fe-S_hydro-lyase_TtdB-typ_cat IPR036660, Fe-S_hydroAse_TtdB_cat_sf |
Pfami | View protein in Pfam PF05683, Fumerase_C, 1 hit |
SUPFAMi | SSF117457, SSF117457, 1 hit |
TIGRFAMsi | TIGR00723, ttdB_fumA_fumB, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TTDB_ECOLI | |
Accessioni | P0AC35Primary (citable) accession number: P0AC35 Secondary accession number(s): P05851, P33131, Q2M9E3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2005 |
Last sequence update: | November 8, 2005 | |
Last modified: | February 23, 2022 | |
This is version 101 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families