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UniProtKB - P0AC23 (FOCA_ECOLI)

Entry version 112 (10 Feb 2021)
Sequence version 1 (08 Nov 2005)
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Protein

Probable formate transporter 1

Gene

focA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the bidirectional transport of formate.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:FOCA-MONOMER
MetaCyc:FOCA-MONOMER

Protein family/group databases

Transport Classification Database

More...TCDBi		1.A.16.1.1, the formate-nitrite transporter (fnt) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable formate transporter 1
Alternative name(s):
Formate channel 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:focA
Synonyms:ycaE
Ordered Locus Names:b0904, JW0887
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei37 – 53HelicalSequence analysisAdd BLAST17
Topological domaini54 – 68ExtracellularSequence analysisAdd BLAST15
Transmembranei69 – 85HelicalSequence analysisAdd BLAST17
Topological domaini86 – 116CytoplasmicSequence analysisAdd BLAST31
Transmembranei117 – 133HelicalSequence analysisAdd BLAST17
Topological domaini134 – 164ExtracellularSequence analysisAdd BLAST31
Transmembranei165 – 183HelicalSequence analysisAdd BLAST19
Topological domaini184 – 191CytoplasmicSequence analysis8
Transmembranei192 – 207HelicalSequence analysisAdd BLAST16
Topological domaini208 – 259ExtracellularSequence analysisAdd BLAST52
Transmembranei260 – 279HelicalSequence analysisAdd BLAST20
Topological domaini280 – 285CytoplasmicSequence analysis6

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000947171 – 285Probable formate transporter 1Add BLAST285

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P0AC23

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P0AC23

PRoteomics IDEntifications database

More...PRIDEi		P0AC23

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4260836, 8 interactors

Database of interacting proteins

More...DIPi		DIP-9670N

Protein interaction database and analysis system

More...IntActi		P0AC23, 1 interactor

STRING: functional protein association networks

More...STRINGi		511145.b0904

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P0AC23

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FNT transporter (TC 2.A.44) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG2116, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_036896_3_0_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P0AC23

Database for complete collections of gene phylogenies

More...PhylomeDBi		P0AC23

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1080.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR023271, Aquaporin-like
IPR000292, For/NO2_transpt
IPR024002, For/NO2_transpt_CS
IPR023999, Formate_transptr_FocA_put

The PANTHER Classification System

More...PANTHERi		PTHR30520, PTHR30520, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01226, Form_Nir_trans, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00790, fnt, 1 hit
TIGR04060, formate_focA, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01005, FORMATE_NITRITE_TP_1, 1 hit
PS01006, FORMATE_NITRITE_TP_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0AC23-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKADNPFDLL LPAAMAKVAE EAGVYKATKH PLKTFYLAIT AGVFISIAFV 
        60         70         80         90        100
FYITATTGTG TMPFGMAKLV GGICFSLGLI LCVVCGADLF TSTVLIVVAK 
       110        120        130        140        150
ASGRITWGQL AKNWLNVYFG NLVGALLFVL LMWLSGEYMT ANGQWGLNVL 
       160        170        180        190        200
QTADHKVHHT FIEAVCLGIL ANLMVCLAVW MSYSGRSLMD KAFIMVLPVA 
       210        220        230        240        250
MFVASGFEHS IANMFMIPMG IVIRDFASPE FWTAVGSAPE NFSHLTVMNF 
       260        270        280 
ITDNLIPVTI GNIIGGGLLV GLTYWVIYLR ENDHH
Length:285
Mass (Da):30,991
Last modified:November 8, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE0B06FFFC362DE16
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA20390 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AP009048 Genomic DNA Translation: BAA35639.1
M26413 Genomic DNA Translation: AAA20390.1 Different initiation.
U00096 Genomic DNA Translation: AAC73990.1

Protein sequence database of the Protein Information Resource

More...PIRi		A32305

NCBI Reference Sequences

More...RefSeqi		NP_415424.1, NC_000913.3
WP_000642546.1, NZ_SSZK01000002.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC73990; AAC73990; b0904
BAA35639; BAA35639; BAA35639

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57728315
945513

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW0887
eco:b0904

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.1372

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009048 Genomic DNA Translation: BAA35639.1
M26413 Genomic DNA Translation: AAA20390.1 Different initiation.
U00096 Genomic DNA Translation: AAC73990.1
PIRiA32305
RefSeqiNP_415424.1, NC_000913.3
WP_000642546.1, NZ_SSZK01000002.1

3D structure databases

SMRiP0AC23
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4260836, 8 interactors
DIPiDIP-9670N
IntActiP0AC23, 1 interactor
STRINGi511145.b0904

Protein family/group databases

TCDBi1.A.16.1.1, the formate-nitrite transporter (fnt) family

Proteomic databases

jPOSTiP0AC23
PaxDbiP0AC23
PRIDEiP0AC23

Genome annotation databases

EnsemblBacteriaiAAC73990; AAC73990; b0904
BAA35639; BAA35639; BAA35639
GeneIDi57728315
945513
KEGGiecj:JW0887
eco:b0904
PATRICifig|1411691.4.peg.1372

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB1238

Phylogenomic databases

eggNOGiCOG2116, Bacteria
HOGENOMiCLU_036896_3_0_6
InParanoidiP0AC23
PhylomeDBiP0AC23

Enzyme and pathway databases

BioCyciEcoCyc:FOCA-MONOMER
MetaCyc:FOCA-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P0AC23

Family and domain databases

Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271, Aquaporin-like
IPR000292, For/NO2_transpt
IPR024002, For/NO2_transpt_CS
IPR023999, Formate_transptr_FocA_put
PANTHERiPTHR30520, PTHR30520, 1 hit
PfamiView protein in Pfam
PF01226, Form_Nir_trans, 1 hit
TIGRFAMsiTIGR00790, fnt, 1 hit
TIGR04060, formate_focA, 1 hit
PROSITEiView protein in PROSITE
PS01005, FORMATE_NITRITE_TP_1, 1 hit
PS01006, FORMATE_NITRITE_TP_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFOCA_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0AC23
Secondary accession number(s): P21501
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: February 10, 2021
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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