UniProtKB - P0AC23 (FOCA_ECOLI)
Protein
Probable formate transporter 1
Gene
focA
Organism
Escherichia coli (strain K12)
Status
Functioni
Involved in the bidirectional transport of formate.
GO - Molecular functioni
- formate transmembrane transporter activity Source: EcoCyc
- identical protein binding Source: EcoCyc
GO - Biological processi
- formate transport Source: EcoCyc
- mixed acid fermentation Source: EcoCyc
- response to acidic pH Source: EcoCyc
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:FOCA-MONOMER MetaCyc:FOCA-MONOMER |
Protein family/group databases
TCDBi | 1.A.16.1.1, the formate-nitrite transporter (fnt) family |
Names & Taxonomyi
Protein namesi | Recommended name: Probable formate transporter 1Alternative name(s): Formate channel 1 |
Gene namesi | Name:focA Synonyms:ycaE Ordered Locus Names:b0904, JW0887 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane 1 Publication; Multi-pass membrane protein 1 Publication
Plasma Membrane
- integral component of plasma membrane Source: EcoCyc
- plasma membrane Source: EcoCyc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 36 | CytoplasmicSequence analysisAdd BLAST | 36 | |
Transmembranei | 37 – 53 | HelicalSequence analysisAdd BLAST | 17 | |
Topological domaini | 54 – 68 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 69 – 85 | HelicalSequence analysisAdd BLAST | 17 | |
Topological domaini | 86 – 116 | CytoplasmicSequence analysisAdd BLAST | 31 | |
Transmembranei | 117 – 133 | HelicalSequence analysisAdd BLAST | 17 | |
Topological domaini | 134 – 164 | ExtracellularSequence analysisAdd BLAST | 31 | |
Transmembranei | 165 – 183 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 184 – 191 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 192 – 207 | HelicalSequence analysisAdd BLAST | 16 | |
Topological domaini | 208 – 259 | ExtracellularSequence analysisAdd BLAST | 52 | |
Transmembranei | 260 – 279 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 280 – 285 | CytoplasmicSequence analysis | 6 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000094717 | 1 – 285 | Probable formate transporter 1Add BLAST | 285 |
Proteomic databases
jPOSTi | P0AC23 |
PaxDbi | P0AC23 |
PRIDEi | P0AC23 |
Interactioni
GO - Molecular functioni
- identical protein binding Source: EcoCyc
Protein-protein interaction databases
BioGRIDi | 4260836, 8 interactors |
DIPi | DIP-9670N |
IntActi | P0AC23, 1 interactor |
STRINGi | 511145.b0904 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2116, Bacteria |
HOGENOMi | CLU_036896_3_0_6 |
InParanoidi | P0AC23 |
PhylomeDBi | P0AC23 |
Family and domain databases
Gene3Di | 1.20.1080.10, 1 hit |
InterProi | View protein in InterPro IPR023271, Aquaporin-like IPR000292, For/NO2_transpt IPR024002, For/NO2_transpt_CS IPR023999, Formate_transptr_FocA_put |
PANTHERi | PTHR30520, PTHR30520, 1 hit |
Pfami | View protein in Pfam PF01226, Form_Nir_trans, 1 hit |
TIGRFAMsi | TIGR00790, fnt, 1 hit TIGR04060, formate_focA, 1 hit |
PROSITEi | View protein in PROSITE PS01005, FORMATE_NITRITE_TP_1, 1 hit PS01006, FORMATE_NITRITE_TP_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P0AC23-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKADNPFDLL LPAAMAKVAE EAGVYKATKH PLKTFYLAIT AGVFISIAFV
60 70 80 90 100
FYITATTGTG TMPFGMAKLV GGICFSLGLI LCVVCGADLF TSTVLIVVAK
110 120 130 140 150
ASGRITWGQL AKNWLNVYFG NLVGALLFVL LMWLSGEYMT ANGQWGLNVL
160 170 180 190 200
QTADHKVHHT FIEAVCLGIL ANLMVCLAVW MSYSGRSLMD KAFIMVLPVA
210 220 230 240 250
MFVASGFEHS IANMFMIPMG IVIRDFASPE FWTAVGSAPE NFSHLTVMNF
260 270 280
ITDNLIPVTI GNIIGGGLLV GLTYWVIYLR ENDHH
Sequence cautioni
The sequence AAA20390 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP009048 Genomic DNA Translation: BAA35639.1 M26413 Genomic DNA Translation: AAA20390.1 Different initiation. U00096 Genomic DNA Translation: AAC73990.1 |
PIRi | A32305 |
RefSeqi | NP_415424.1, NC_000913.3 WP_000642546.1, NZ_SSZK01000002.1 |
Genome annotation databases
EnsemblBacteriai | AAC73990; AAC73990; b0904 BAA35639; BAA35639; BAA35639 |
GeneIDi | 57728315 945513 |
KEGGi | ecj:JW0887 eco:b0904 |
PATRICi | fig|1411691.4.peg.1372 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP009048 Genomic DNA Translation: BAA35639.1 M26413 Genomic DNA Translation: AAA20390.1 Different initiation. U00096 Genomic DNA Translation: AAC73990.1 |
PIRi | A32305 |
RefSeqi | NP_415424.1, NC_000913.3 WP_000642546.1, NZ_SSZK01000002.1 |
3D structure databases
SMRi | P0AC23 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4260836, 8 interactors |
DIPi | DIP-9670N |
IntActi | P0AC23, 1 interactor |
STRINGi | 511145.b0904 |
Protein family/group databases
TCDBi | 1.A.16.1.1, the formate-nitrite transporter (fnt) family |
Proteomic databases
jPOSTi | P0AC23 |
PaxDbi | P0AC23 |
PRIDEi | P0AC23 |
Genome annotation databases
EnsemblBacteriai | AAC73990; AAC73990; b0904 BAA35639; BAA35639; BAA35639 |
GeneIDi | 57728315 945513 |
KEGGi | ecj:JW0887 eco:b0904 |
PATRICi | fig|1411691.4.peg.1372 |
Organism-specific databases
EchoBASEi | EB1238 |
Phylogenomic databases
eggNOGi | COG2116, Bacteria |
HOGENOMi | CLU_036896_3_0_6 |
InParanoidi | P0AC23 |
PhylomeDBi | P0AC23 |
Enzyme and pathway databases
BioCyci | EcoCyc:FOCA-MONOMER MetaCyc:FOCA-MONOMER |
Miscellaneous databases
PROi | PR:P0AC23 |
Family and domain databases
Gene3Di | 1.20.1080.10, 1 hit |
InterProi | View protein in InterPro IPR023271, Aquaporin-like IPR000292, For/NO2_transpt IPR024002, For/NO2_transpt_CS IPR023999, Formate_transptr_FocA_put |
PANTHERi | PTHR30520, PTHR30520, 1 hit |
Pfami | View protein in Pfam PF01226, Form_Nir_trans, 1 hit |
TIGRFAMsi | TIGR00790, fnt, 1 hit TIGR04060, formate_focA, 1 hit |
PROSITEi | View protein in PROSITE PS01005, FORMATE_NITRITE_TP_1, 1 hit PS01006, FORMATE_NITRITE_TP_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FOCA_ECOLI | |
Accessioni | P0AC23Primary (citable) accession number: P0AC23 Secondary accession number(s): P21501 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2005 |
Last sequence update: | November 8, 2005 | |
Last modified: | February 10, 2021 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families