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Protein

Dihydroneopterin aldolase

Gene

folB

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6-hydroxymethyldihydropterin, but it can also catalyze the epimerization of carbon 2' of dihydroneopterin to dihydromonapterin at appreciable velocity.By similarity

Catalytic activityi

7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde.By similarity
7,8-dihydroneopterin = 7,8-dihydromonapterin.By similarity

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Dihydroneopterin aldolase (folB)
  4. no protein annotated in this organism
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei21SubstrateBy similarity1
Binding sitei53SubstrateBy similarity1
Active sitei98Proton donor/acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Lyase
Biological processFolate biosynthesis

Enzyme and pathway databases

UniPathwayi
UPA00077;UER00154

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroneopterin aldolase (EC:4.1.2.25By similarity)
Short name:
DHNA
Alternative name(s):
7,8-dihydroneopterin 2'-epimerase
7,8-dihydroneopterin aldolase
7,8-dihydroneopterin epimerase (EC:5.1.99.8By similarity)
Dihydroneopterin epimerase
Gene namesi
Name:folB
Ordered Locus Names:c3808
OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Taxonomic identifieri199310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000001410 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001682701 – 122Dihydroneopterin aldolaseAdd BLAST122

Interactioni

Subunit structurei

Homooctamer.By similarity

Protein-protein interaction databases

STRINGi199310.c3808

Structurei

3D structure databases

ProteinModelPortaliP0AC17
SMRiP0AC17
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni72 – 73Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the DHNA family.Curated

Phylogenomic databases

eggNOGiENOG4107ZVW Bacteria
COG1539 LUCA
HOGENOMiHOG000217627
KOiK01633
OMAiGIYEWEK

Family and domain databases

CDDicd00534 DHNA_DHNTPE, 1 hit
InterProiView protein in InterPro
IPR006156 Dihydroneopterin_aldolase
IPR006157 FolB_dom
PfamiView protein in Pfam
PF02152 FolB, 1 hit
SMARTiView protein in SMART
SM00905 FolB, 1 hit
TIGRFAMsiTIGR00525 folB, 1 hit
TIGR00526 folB_dom, 1 hit

Sequencei

Sequence statusi: Complete.

P0AC17-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDIVFIEQLS VITTIGVYDW EQTIEQKLVF DIEMAWDNRK AAKSDDVADC
60 70 80 90 100
LSYADIAETV VSHVEGARFA LVERVAEEVA ELLLARFNSP WVRIKLSKPG
110 120
AVARAANVGV IIERGNNLKE NN
Length:122
Mass (Da):13,620
Last modified:November 8, 2005 - v1
Checksum:iBEA82C1E0AA38A55
GO

Sequence cautioni

The sequence AAN82253 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014075 Genomic DNA Translation: AAN82253.1 Different initiation.
RefSeqiWP_001295541.1, NC_004431.1

Genome annotation databases

EnsemblBacteriaiAAN82253; AAN82253; c3808
KEGGiecc:c3808

Similar proteinsi

Entry informationi

Entry nameiFOLB_ECOL6
AccessioniPrimary (citable) accession number: P0AC17
Secondary accession number(s): P31055, P76659
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: May 23, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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