UniProtKB - P0ABZ6 (SURA_ECOLI)
Protein
Chaperone SurA
Gene
surA
Organism
Escherichia coli (strain K12)
Status
Functioni
Chaperone involved in the correct folding and assembly of outer membrane proteins, such as OmpA, OmpF and LamB. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. Essential for the survival of E.coli in stationary phase. Required for pilus biogenesis.3 Publications
Catalytic activityi
- EC:5.2.1.8
GO - Molecular functioni
- peptide binding Source: EcoCyc
- peptidyl-prolyl cis-trans isomerase activity Source: EcoCyc
- unfolded protein binding Source: EcoCyc
GO - Biological processi
- chaperone-mediated protein folding Source: EcoCyc
- Gram-negative-bacterium-type cell outer membrane assembly Source: EcoliWiki
- maintenance of stationary phase Source: EcoliWiki
- protein folding Source: EcoCyc
- protein stabilization Source: EcoCyc
Keywordsi
Molecular function | Chaperone, Isomerase, Rotamase |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10985-MONOMER MetaCyc:EG10985-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Chaperone SurAAlternative name(s): Rotamase SurA Survival protein A |
Gene namesi | Name:surA Ordered Locus Names:b0053, JW0052 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Other locations
Note: Is capable of associating with the outer membrane.
Other locations
- outer membrane-bounded periplasmic space Source: EcoCyc
Keywords - Cellular componenti
PeriplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | 3 PublicationsAdd BLAST | 20 | |
ChainiPRO_0000025542 | 21 – 428 | Chaperone SurAAdd BLAST | 408 |
Proteomic databases
jPOSTi | P0ABZ6 |
PaxDbi | P0ABZ6 |
PRIDEi | P0ABZ6 |
2D gel databases
SWISS-2DPAGEi | P0ABZ6 |
Interactioni
Binary interactionsi
P0ABZ6
With | #Exp. | IntAct |
---|---|---|
bamB [P77774] | 2 | EBI-558651,EBI-907297 |
GO - Molecular functioni
- unfolded protein binding Source: EcoCyc
Protein-protein interaction databases
BioGRIDi | 4261014, 418 interactors |
DIPi | DIP-35827N |
IntActi | P0ABZ6, 10 interactors |
STRINGi | 511145.b0053 |
Chemistry databases
BindingDBi | P0ABZ6 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0ABZ6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P0ABZ6 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 171 – 272 | PpiC 1Add BLAST | 102 | |
Domaini | 282 – 382 | PpiC 2Add BLAST | 101 |
Domaini
The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA function as a SurA protein with a deletion of the parvulin domains is almost completely functional in vivo. The N-terminal region and the C-terminal tail are also required for porin recognition.1 Publication
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | COG0760, Bacteria |
HOGENOMi | CLU_034646_11_0_6 |
InParanoidi | P0ABZ6 |
PhylomeDBi | P0ABZ6 |
Family and domain databases
HAMAPi | MF_01183, Chaperone_SurA, 1 hit |
InterProi | View protein in InterPro IPR000297, PPIase_PpiC IPR023058, PPIase_PpiC_CS IPR023034, PPIase_SurA IPR015391, SurA_N IPR027304, Trigger_fact/SurA_dom_sf |
Pfami | View protein in Pfam PF00639, Rotamase, 1 hit PF09312, SurA_N, 1 hit |
SUPFAMi | SSF109998, SSF109998, 1 hit |
PROSITEi | View protein in PROSITE PS01096, PPIC_PPIASE_1, 2 hits PS50198, PPIC_PPIASE_2, 2 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P0ABZ6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKNWKTLLLG IAMIANTSFA APQVVDKVAA VVNNGVVLES DVDGLMQSVK
60 70 80 90 100
LNAAQARQQL PDDATLRHQI MERLIMDQII LQMGQKMGVK ISDEQLDQAI
110 120 130 140 150
ANIAKQNNMT LDQMRSRLAY DGLNYNTYRN QIRKEMIISE VRNNEVRRRI
160 170 180 190 200
TILPQEVESL AQQVGNQNDA STELNLSHIL IPLPENPTSD QVNEAESQAR
210 220 230 240 250
AIVDQARNGA DFGKLAIAHS ADQQALNGGQ MGWGRIQELP GIFAQALSTA
260 270 280 290 300
KKGDIVGPIR SGVGFHILKV NDLRGESKNI SVTEVHARHI LLKPSPIMTD
310 320 330 340 350
EQARVKLEQI AADIKSGKTT FAAAAKEFSQ DPGSANQGGD LGWATPDIFD
360 370 380 390 400
PAFRDALTRL NKGQMSAPVH SSFGWHLIEL LDTRNVDKTD AAQKDRAYRM
410 420
LMNRKFSEEA ASWMQEQRAS AYVKILSN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 25 | V → D (Ref. 1) Curated | 1 | |
Sequence conflicti | 116 | S → T (Ref. 1) Curated | 1 | |
Sequence conflicti | 213 | G → GFG (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC73164.1 AP009048 Genomic DNA Translation: BAB96620.2 M68521 Genomic DNA Translation: AAA24304.1 AB013134 Genomic DNA Translation: BAA34131.1 |
PIRi | E64726 |
RefSeqi | NP_414595.1, NC_000913.3 WP_000800457.1, NZ_STEB01000010.1 |
Genome annotation databases
EnsemblBacteriai | AAC73164; AAC73164; b0053 BAB96620; BAB96620; BAB96620 |
GeneIDi | 58460807 944812 |
KEGGi | ecj:JW0052 eco:b0053 |
PATRICi | fig|1411691.4.peg.2230 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC73164.1 AP009048 Genomic DNA Translation: BAB96620.2 M68521 Genomic DNA Translation: AAA24304.1 AB013134 Genomic DNA Translation: BAA34131.1 |
PIRi | E64726 |
RefSeqi | NP_414595.1, NC_000913.3 WP_000800457.1, NZ_STEB01000010.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1M5Y | X-ray | 3.00 | A/B/C/D | 21-428 | [»] | |
2PV1 | X-ray | 1.30 | A | 172-274 | [»] | |
2PV2 | X-ray | 1.30 | A/B/C/D | 172-274 | [»] | |
2PV3 | X-ray | 3.39 | A/B | 21-428 | [»] | |
SMRi | P0ABZ6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4261014, 418 interactors |
DIPi | DIP-35827N |
IntActi | P0ABZ6, 10 interactors |
STRINGi | 511145.b0053 |
Chemistry databases
BindingDBi | P0ABZ6 |
ChEMBLi | CHEMBL4295570 |
2D gel databases
SWISS-2DPAGEi | P0ABZ6 |
Proteomic databases
jPOSTi | P0ABZ6 |
PaxDbi | P0ABZ6 |
PRIDEi | P0ABZ6 |
Genome annotation databases
EnsemblBacteriai | AAC73164; AAC73164; b0053 BAB96620; BAB96620; BAB96620 |
GeneIDi | 58460807 944812 |
KEGGi | ecj:JW0052 eco:b0053 |
PATRICi | fig|1411691.4.peg.2230 |
Organism-specific databases
EchoBASEi | EB0978 |
Phylogenomic databases
eggNOGi | COG0760, Bacteria |
HOGENOMi | CLU_034646_11_0_6 |
InParanoidi | P0ABZ6 |
PhylomeDBi | P0ABZ6 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10985-MONOMER MetaCyc:EG10985-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P0ABZ6 |
PROi | PR:P0ABZ6 |
Family and domain databases
HAMAPi | MF_01183, Chaperone_SurA, 1 hit |
InterProi | View protein in InterPro IPR000297, PPIase_PpiC IPR023058, PPIase_PpiC_CS IPR023034, PPIase_SurA IPR015391, SurA_N IPR027304, Trigger_fact/SurA_dom_sf |
Pfami | View protein in Pfam PF00639, Rotamase, 1 hit PF09312, SurA_N, 1 hit |
SUPFAMi | SSF109998, SSF109998, 1 hit |
PROSITEi | View protein in PROSITE PS01096, PPIC_PPIASE_1, 2 hits PS50198, PPIC_PPIASE_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SURA_ECOLI | |
Accessioni | P0ABZ6Primary (citable) accession number: P0ABZ6 Secondary accession number(s): P21202 Q8KMY0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2005 |
Last sequence update: | November 8, 2005 | |
Last modified: | April 7, 2021 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references