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Protein

Flagellar motor switch protein FliG

Gene

fliG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei160Part of the EHPQR-motif1

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • motor activity Source: InterPro

GO - Biological processi

  • bacterial-type flagellum assembly Source: EcoCyc
  • bacterial-type flagellum-dependent cell motility Source: EcoCyc
  • chemotaxis Source: UniProtKB-KW

Keywordsi

Biological processChemotaxis, Flagellar rotation

Enzyme and pathway databases

BioCyciEcoCyc:FLIG-FLAGELLAR-SWITCH-PROTEIN

Names & Taxonomyi

Protein namesi
Recommended name:
Flagellar motor switch protein FliG
Gene namesi
Name:fliG
Synonyms:fla AII.2, fla BII
Ordered Locus Names:b1939, JW1923
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11654 fliG

Subcellular locationi

GO - Cellular componenti

  • bacterial-type flagellum basal body Source: UniProtKB-SubCell
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Bacterial flagellum, Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi252Q → W: Decreases binding to YcgR, significantly improves motility in a pdeH disruption mutant. 1 Publication1
Mutagenesisi284D → W: Slightly improves motility in a pdeH disruption mutant. 1 Publication1
Mutagenesisi292N → W: Decreases binding to YcgR, significantly improves motility in a pdeH disruption mutant. 1 Publication1
Mutagenesisi295P → W: Decreases binding to YcgR, significantly improves motility in a pdeH disruption mutant. 1 Publication1
Mutagenesisi298L → W: Slightly improves motility in a pdeH disruption mutant. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001840891 – 331Flagellar motor switch protein FliGAdd BLAST331

Proteomic databases

PaxDbiP0ABZ1
PRIDEiP0ABZ1

Interactioni

Subunit structurei

Forms dimers and other homooligomers. Interacts with MotA via residues in its C-terminus. Interacts with flagellar brake protein YcgR.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi4260384, 25 interactors
ComplexPortaliCPX-1082 Flagellar Motor Switch Complex, CW variant
CPX-1085 Flagellar Motor Switch Complex, CCW variant
DIPiDIP-408N
IntActiP0ABZ1, 26 interactors
MINTiP0ABZ1
STRINGi316385.ECDH10B_2081

Structurei

3D structure databases

ProteinModelPortaliP0ABZ1
SMRiP0ABZ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi125 – 128Part of the EHPQR-motif4

Sequence similaritiesi

Belongs to the FliG family.Curated

Phylogenomic databases

eggNOGiENOG4105CS3 Bacteria
COG1536 LUCA
HOGENOMiHOG000257647
InParanoidiP0ABZ1
KOiK02410
OMAiKNMSQRA
PhylomeDBiP0ABZ1

Family and domain databases

InterProiView protein in InterPro
IPR000090 Flg_Motor_Flig
IPR023087 Flg_Motor_Flig_C
IPR011002 FliG_a-hlx
IPR032779 FliG_M
IPR028263 FliG_N
PANTHERiPTHR30534 PTHR30534, 1 hit
PfamiView protein in Pfam
PF01706 FliG_C, 1 hit
PF14841 FliG_M, 1 hit
PF14842 FliG_N, 1 hit
PIRSFiPIRSF003161 FliG, 1 hit
PRINTSiPR00954 FLGMOTORFLIG
SUPFAMiSSF48029 SSF48029, 2 hits
TIGRFAMsiTIGR00207 fliG, 1 hit

Sequencei

Sequence statusi: Complete.

P0ABZ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNLTGTDKS VILLMTIGED RAAEVFKHLS QREVQTLSAA MANVTQISNK
60 70 80 90 100
QLTDVLAEFE QEAEQFAALN INANDYLRSV LVKALGEERA ASLLEDILET
110 120 130 140 150
RDTASGIETL NFMEPQSAAD LIRDEHPQII ATILVHLKRA QAADILALFD
160 170 180 190 200
ERLRHDVMLR IATFGGVQPA ALAELTEVLN GLLDGQNLKR SKMGGVRTAA
210 220 230 240 250
EIINLMKTQQ EEAVITAVRE FDGELAQKII DEMFLFENLV DVDDRSIQRL
260 270 280 290 300
LQEVDSESLL IALKGAEQPL REKFLRNMSQ RAADILRDDL ANRGPVRLSQ
310 320 330
VENEQKAILL IVRRLAETGE MVIGSGEDTY V
Length:331
Mass (Da):36,776
Last modified:October 25, 2005 - v1
Checksum:iE5CB4C0415C6E178
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159 – 170LRIAT…GVQPA → FVSHLWRRAPS in AAA75241 (PubMed:8224881).CuratedAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13243 Genomic DNA Translation: AAA75241.1
U46011 Genomic DNA Translation: AAB60186.1
U00096 Genomic DNA Translation: AAC75006.1
AP009048 Genomic DNA Translation: BAA15764.1
D89826 Genomic DNA Translation: BAA14030.1
PIRiH64957
RefSeqiNP_416449.1, NC_000913.3
WP_000067950.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75006; AAC75006; b1939
BAA15764; BAA15764; BAA15764
GeneIDi946451
KEGGiecj:JW1923
eco:b1939
PATRICifig|1411691.4.peg.312

Similar proteinsi

Entry informationi

Entry nameiFLIG_ECOLI
AccessioniPrimary (citable) accession number: P0ABZ1
Secondary accession number(s): P31067, P76915
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: June 20, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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