UniProtKB - P0ABY7 (FLHC_ECOLI)
Protein
Flagellar transcriptional regulator FlhC
Gene
flhC
Organism
Escherichia coli (strain K12)
Status
Functioni
Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.3 Publications
Cofactori
Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 137 | Zinc | 1 | |
Metal bindingi | 140 | Zinc | 1 | |
Metal bindingi | 157 | Zinc | 1 | |
Metal bindingi | 160 | Zinc | 1 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-UniRule
- zinc ion binding Source: UniProtKB-UniRule
GO - Biological processi
- bacterial-type flagellum organization Source: UniProtKB-KW
- positive regulation of transcription, DNA-templated Source: InterPro
- regulation of bacterial-type flagellum assembly Source: UniProtKB-UniRule
- transcription, DNA-templated Source: EcoCyc
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Bacterial flagellum biogenesis, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
BioCyci | EcoCyc:MONOMER0-2488 |
Names & Taxonomyi
Protein namesi | Recommended name: Flagellar transcriptional regulator FlhC |
Gene namesi | Name:flhC Synonyms:flaI Ordered Locus Names:b1891, JW1880 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm Curated
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000064337 | 1 – 192 | Flagellar transcriptional regulator FlhCAdd BLAST | 192 |
Proteomic databases
PaxDbi | P0ABY7 |
PRIDEi | P0ABY7 |
Expressioni
Inductioni
Expression is regulated by a large number of systems, including induction by quorum sensing via the two-component regulatory system QseB/QseC, induction by cAMP-CRP, repression by high osmolarity via OmpR and repression by H-NS.3 Publications
Interactioni
Subunit structurei
Heterohexamer composed of two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer assembles by dimerization of two heterotrimers.
1 PublicationProtein-protein interaction databases
BioGRIDi | 4262244, 9 interactors |
ComplexPortali | CPX-2508, FlhDC transcriptional regulation complex |
DIPi | DIP-9645N |
IntActi | P0ABY7, 1 interactor |
STRINGi | 511145.b1891 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0ABY7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P0ABY7 |
Family & Domainsi
Sequence similaritiesi
Belongs to the FlhC family.Curated
Phylogenomic databases
eggNOGi | ENOG502Z927, Bacteria |
HOGENOMi | CLU_122824_0_0_6 |
Family and domain databases
HAMAPi | MF_01891, FhlC, 1 hit |
InterProi | View protein in InterPro IPR007944, FlhC |
Pfami | View protein in Pfam PF05280, FlhC, 1 hit |
PIRSFi | PIRSF003159, FlhC, 1 hit |
i Sequence
Sequence statusi: Complete.
P0ABY7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSEKSIVQEA RDIQLAMELI TLGARLQMLE SETQLSRGRL IKLYKELRGS
60 70 80 90 100
PPPKGMLPFS TDWFMTWEQN VHASMFCNAW QFLLKTGLCN GVDAVIKAYR
110 120 130 140 150
LYLEQCPQAE EGPLLALTRA WTLVRFVESG LLQLSSCNCC GGNFITHAHQ
160 170 180 190
PVGSFACSLC QPPSRAVKRR KLSQNPADII PQLLDEQRVQ AV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 149 | H → D in AAA23788 (PubMed:2832369).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M19439 Genomic DNA Translation: AAA23788.1 U00096 Genomic DNA Translation: AAC74961.1 AP009048 Genomic DNA Translation: BAA15712.1 |
PIRi | C64952, XMECIF |
RefSeqi | NP_416405.1, NC_000913.3 WP_001291603.1, NZ_STEB01000026.1 |
Genome annotation databases
EnsemblBacteriai | AAC74961; AAC74961; b1891 BAA15712; BAA15712; BAA15712 |
GeneIDi | 49584358 947280 |
KEGGi | ecj:JW1880 eco:b1891 |
PATRICi | fig|1411691.4.peg.356 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M19439 Genomic DNA Translation: AAA23788.1 U00096 Genomic DNA Translation: AAC74961.1 AP009048 Genomic DNA Translation: BAA15712.1 |
PIRi | C64952, XMECIF |
RefSeqi | NP_416405.1, NC_000913.3 WP_001291603.1, NZ_STEB01000026.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2AVU | X-ray | 3.00 | E/F | 1-192 | [»] | |
SMRi | P0ABY7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4262244, 9 interactors |
ComplexPortali | CPX-2508, FlhDC transcriptional regulation complex |
DIPi | DIP-9645N |
IntActi | P0ABY7, 1 interactor |
STRINGi | 511145.b1891 |
Proteomic databases
PaxDbi | P0ABY7 |
PRIDEi | P0ABY7 |
Genome annotation databases
EnsemblBacteriai | AAC74961; AAC74961; b1891 BAA15712; BAA15712; BAA15712 |
GeneIDi | 49584358 947280 |
KEGGi | ecj:JW1880 eco:b1891 |
PATRICi | fig|1411691.4.peg.356 |
Organism-specific databases
EchoBASEi | EB0315 |
Phylogenomic databases
eggNOGi | ENOG502Z927, Bacteria |
HOGENOMi | CLU_122824_0_0_6 |
Enzyme and pathway databases
BioCyci | EcoCyc:MONOMER0-2488 |
Miscellaneous databases
EvolutionaryTracei | P0ABY7 |
PROi | PR:P0ABY7 |
Family and domain databases
HAMAPi | MF_01891, FhlC, 1 hit |
InterProi | View protein in InterPro IPR007944, FlhC |
Pfami | View protein in Pfam PF05280, FlhC, 1 hit |
PIRSFi | PIRSF003159, FlhC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FLHC_ECOLI | |
Accessioni | P0ABY7Primary (citable) accession number: P0ABY7 Secondary accession number(s): P11165, P76303 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 25, 2005 |
Last sequence update: | October 25, 2005 | |
Last modified: | December 2, 2020 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families