UniProtKB - P0ABY2 (FLIT_ECOLI)
Protein
Flagellar protein FliT
Gene
fliT
Organism
Escherichia coli (strain K12)
Status
Functioni
Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD. As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus.UniRule annotation
GO - Biological processi
- bacterial-type flagellum-dependent cell motility Source: EcoCyc
- bacterial-type flagellum organization Source: UniProtKB-KW
- negative regulation of bacterial-type flagellum assembly Source: UniProtKB-UniRule
- protein folding Source: UniProtKB-UniRule
Keywordsi
Molecular function | Chaperone, Repressor |
Biological process | Bacterial flagellum biogenesis, Transcription, Transcription regulation |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11389-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Flagellar protein FliTUniRule annotation |
Gene namesi | Name:fliTUniRule annotation Ordered Locus Names:b1926, JW1911 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- cytosol Curated
Cytosol
- cytosol Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000180974 | 1 – 121 | Flagellar protein FliTAdd BLAST | 121 |
Proteomic databases
PaxDbi | P0ABY2 |
PRIDEi | P0ABY2 |
Interactioni
Subunit structurei
Homodimer.
Interacts with FliD and FlhC.
UniRule annotationBinary interactionsi
P0ABY2
With | #Exp. | IntAct |
---|---|---|
fliD [P24216] | 4 | EBI-1114780,EBI-1126352 |
Protein-protein interaction databases
BioGRIDi | 4260367, 21 interactors 850790, 4 interactors |
IntActi | P0ABY2, 21 interactors |
STRINGi | 511145.b1926 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 50 | Required for homodimerizationUniRule annotationAdd BLAST | 50 | |
Regioni | 60 – 98 | FliD bindingUniRule annotationAdd BLAST | 39 |
Sequence similaritiesi
Belongs to the FliT family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG5032ZV7, Bacteria |
HOGENOMi | CLU_155793_1_1_6 |
Family and domain databases
HAMAPi | MF_01180, FliT, 1 hit |
InterProi | View protein in InterPro IPR008622, FliT |
Pfami | View protein in Pfam PF05400, FliT, 1 hit |
i Sequence
Sequence statusi: Complete.
P0ABY2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNHAPHLYFA WQQLVEKSQL MLRLATEEQW DELIASEMAY VNAVQEIAHL
60 70 80 90 100
TEEVDPSTTM QEQLRPMLRL ILDNESKVKQ LLQIRMDELA KLVGQSSVQK
110 120
SVLSAYGDQG GFVLAPQDNL F
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M85240 Genomic DNA Translation: AAA23792.1 U00096 Genomic DNA Translation: AAC74993.1 AP009048 Genomic DNA Translation: BAA15754.1 |
PIRi | C64956 |
RefSeqi | NP_416436.1, NC_000913.3 WP_001015033.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC74993; AAC74993; b1926 BAA15754; BAA15754; BAA15754 |
GeneIDi | 946433 |
KEGGi | ecj:JW1911 eco:b1926 |
PATRICi | fig|1411691.4.peg.323 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M85240 Genomic DNA Translation: AAA23792.1 U00096 Genomic DNA Translation: AAC74993.1 AP009048 Genomic DNA Translation: BAA15754.1 |
PIRi | C64956 |
RefSeqi | NP_416436.1, NC_000913.3 WP_001015033.1, NZ_LN832404.1 |
3D structure databases
SMRi | P0ABY2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4260367, 21 interactors 850790, 4 interactors |
IntActi | P0ABY2, 21 interactors |
STRINGi | 511145.b1926 |
Proteomic databases
PaxDbi | P0ABY2 |
PRIDEi | P0ABY2 |
Genome annotation databases
EnsemblBacteriai | AAC74993; AAC74993; b1926 BAA15754; BAA15754; BAA15754 |
GeneIDi | 946433 |
KEGGi | ecj:JW1911 eco:b1926 |
PATRICi | fig|1411691.4.peg.323 |
Organism-specific databases
EchoBASEi | EB1362 |
Phylogenomic databases
eggNOGi | ENOG5032ZV7, Bacteria |
HOGENOMi | CLU_155793_1_1_6 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11389-MONOMER |
Miscellaneous databases
PROi | PR:P0ABY2 |
Family and domain databases
HAMAPi | MF_01180, FliT, 1 hit |
InterProi | View protein in InterPro IPR008622, FliT |
Pfami | View protein in Pfam PF05400, FliT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FLIT_ECOLI | |
Accessioni | P0ABY2Primary (citable) accession number: P0ABY2 Secondary accession number(s): P26610 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 25, 2005 |
Last sequence update: | October 25, 2005 | |
Last modified: | December 2, 2020 | |
This is version 104 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families