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Entry version 108 (16 Oct 2019)
Sequence version 1 (25 Oct 2005)
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Protein

Biopolymer transport protein ExbB

Gene

exbB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBacteriocin transport, Protein transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:EG10271-MONOMER
ECOL316407:JW2974-MONOMER
MetaCyc:EG10271-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.30.2.1 the h(+)- or na(+)-translocating bacterial flagellar motor/exbbd outer membrane transport energizer (mot/exb) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Biopolymer transport protein ExbB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:exbB
Ordered Locus Names:b3006, JW2974
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

Escherichia coli strain K12 genome database

More...
EcoGenei
EG10271 exbB

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 15PeriplasmicCuratedAdd BLAST15
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei16 – 39HelicalCuratedAdd BLAST24
Topological domaini40 – 127CytoplasmicCuratedAdd BLAST88
Transmembranei128 – 155HelicalCuratedAdd BLAST28
Topological domaini156 – 161PeriplasmicCurated6
Transmembranei162 – 194HelicalCuratedAdd BLAST33
Topological domaini195 – 244CytoplasmicCuratedAdd BLAST50

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001457991 – 244Biopolymer transport protein ExbBAdd BLAST244

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P0ABU7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P0ABU7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0ABU7

PRoteomics IDEntifications database

More...
PRIDEi
P0ABU7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced 2.4-fold by hydroxyurea.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The accessory proteins ExbB and ExbD seem to form a complex with TonB.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4261412, 998 interactors
849794, 2 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1083 Vitamin B12 outer membrane transporter complex
CPX-2843 Ferrichrome outer membrane transporter complex
CPX-3576 Ferric-citrate outer membrane transporter complex
CPX-3577 Ferric-catecholate outer membrane transporter complex
CPX-3578 Ferric-enterobactin outer membrane transporter complex
CPX-3579 Ferric-coprogen outer membrane transporter complex
CPX-3580 fiu outer membrane transporter complex
CPX-3585 Uncharacterized yncD-DHBS outer membrane transporter complex

Database of interacting proteins

More...
DIPi
DIP-47841N

Protein interaction database and analysis system

More...
IntActi
P0ABU7, 29 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b3006

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1244
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0ABU7

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ExbB/TolQ family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105CWK Bacteria
COG0811 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000134793

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0ABU7

KEGG Orthology (KO)

More...
KOi
K03561

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0ABU7

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002898 MotA_ExbB_proton_chnl
IPR014164 TonB_ExbB_1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01618 MotA_ExbB, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02797 exbB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0ABU7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNNLMQTDL SVWGMYQHAD IVVKCVMIGL ILASVVTWAI FFSKSVEFFN
60 70 80 90 100
QKRRLKREQQ LLAEARSLNQ ANDIAADFGS KSLSLHLLNE AQNELELSEG
110 120 130 140 150
SDDNEGIKER TSFRLERRVA AVGRQMGRGN GYLATIGAIS PFVGLFGTVW
160 170 180 190 200
GIMNSFIGIA QTQTTNLAVV APGIAEALLA TAIGLVAAIP AVVIYNVFAR
210 220 230 240
QIGGFKAMLG DVAAQVLLLQ SRDLDLEASA AAHPVRVAQK LRAG
Length:244
Mass (Da):26,287
Last modified:October 25, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCEB63893A80BA71F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti51Q → L in AAA23732 (PubMed:2670903).Curated1
Sequence conflicti236R → A in AAA23732 (PubMed:2670903).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M28819 Genomic DNA Translation: AAA23732.1
U28377 Genomic DNA Translation: AAA69173.1
U00096 Genomic DNA Translation: AAC76042.1
AP009048 Genomic DNA Translation: BAE77064.1

Protein sequence database of the Protein Information Resource

More...
PIRi
D65087 BVECXB

NCBI Reference Sequences

More...
RefSeqi
NP_417479.1, NC_000913.3
WP_000527844.1, NZ_STEB01000001.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC76042; AAC76042; b3006
BAE77064; BAE77064; BAE77064

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
945420

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW2974
eco:b3006

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.3723

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28819 Genomic DNA Translation: AAA23732.1
U28377 Genomic DNA Translation: AAA69173.1
U00096 Genomic DNA Translation: AAC76042.1
AP009048 Genomic DNA Translation: BAE77064.1
PIRiD65087 BVECXB
RefSeqiNP_417479.1, NC_000913.3
WP_000527844.1, NZ_STEB01000001.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5SV0X-ray2.60A/B/C/D/E/F/G/H/I/J1-244[»]
5SV1X-ray3.50A/B/C/D/E/F/G/H/I/J1-244[»]
5ZFPX-ray2.84A/B/C/D/E/F/G/H/I/J/K/L1-244[»]
5ZFUelectron microscopy6.70A/B/C/D/E/F1-244[»]
5ZFVelectron microscopy7.10A/B/C/D/E1-244[»]
SMRiP0ABU7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi4261412, 998 interactors
849794, 2 interactors
ComplexPortaliCPX-1083 Vitamin B12 outer membrane transporter complex
CPX-2843 Ferrichrome outer membrane transporter complex
CPX-3576 Ferric-citrate outer membrane transporter complex
CPX-3577 Ferric-catecholate outer membrane transporter complex
CPX-3578 Ferric-enterobactin outer membrane transporter complex
CPX-3579 Ferric-coprogen outer membrane transporter complex
CPX-3580 fiu outer membrane transporter complex
CPX-3585 Uncharacterized yncD-DHBS outer membrane transporter complex
DIPiDIP-47841N
IntActiP0ABU7, 29 interactors
STRINGi511145.b3006

Protein family/group databases

TCDBi1.A.30.2.1 the h(+)- or na(+)-translocating bacterial flagellar motor/exbbd outer membrane transport energizer (mot/exb) superfamily

Proteomic databases

EPDiP0ABU7
jPOSTiP0ABU7
PaxDbiP0ABU7
PRIDEiP0ABU7

Genome annotation databases

EnsemblBacteriaiAAC76042; AAC76042; b3006
BAE77064; BAE77064; BAE77064
GeneIDi945420
KEGGiecj:JW2974
eco:b3006
PATRICifig|1411691.4.peg.3723

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0267
EcoGeneiEG10271 exbB

Phylogenomic databases

eggNOGiENOG4105CWK Bacteria
COG0811 LUCA
HOGENOMiHOG000134793
InParanoidiP0ABU7
KOiK03561
PhylomeDBiP0ABU7

Enzyme and pathway databases

BioCyciEcoCyc:EG10271-MONOMER
ECOL316407:JW2974-MONOMER
MetaCyc:EG10271-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P0ABU7

Family and domain databases

InterProiView protein in InterPro
IPR002898 MotA_ExbB_proton_chnl
IPR014164 TonB_ExbB_1
PfamiView protein in Pfam
PF01618 MotA_ExbB, 1 hit
TIGRFAMsiTIGR02797 exbB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEXBB_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0ABU7
Secondary accession number(s): P18783, Q2M9J2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: October 16, 2019
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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