Anaerobic C4-dicarboxylate transporter DcuC

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• succinate:fumarate antiporter activity Source: EcoCyc <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.6

    "Functioning of DcuC as the C4-dicarboxylate carrier during glucose fermentation by Escherichia coli."
    Zientz E., Janausch I.G., Six S., Unden G.
    J. Bacteriol. 181:3716-3720(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.

GO - Biological processⁱ

• C4-dicarboxylate transport Source: EcoliWiki <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • Ref.1

    "Identification of a third secondary carrier (DcuC) for anaerobic C4-dicarboxylate transport in Escherichia coli: roles of the three Dcu carriers in uptake and exchange."
    Zientz E., Six S., Unden G.
    J. Bacteriol. 178:7241-7247(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
• mixed acid fermentation Source: EcoCyc <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • Ref.6

    "Functioning of DcuC as the C4-dicarboxylate carrier during glucose fermentation by Escherichia coli."
    Zientz E., Janausch I.G., Six S., Unden G.
    J. Bacteriol. 181:3716-3720(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

GO - Cellular componentⁱ

• integral component of plasma membrane Source: EcoCycInferred from sequence modelⁱ
  • "The dcuD (former yhcL) gene product of Escherichia coli as a member of the DcuC family of C4-dicarboxylate carriers: lack of evident expression."
    Janausch I.G., Unden G.
    Arch. Microbiol. 172:219-226(1999) [PubMed] [Europe PMC] [Abstract]
• plasma membrane Source: EcoCycInferred from direct assayⁱ
  • Ref.7

    "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: SUBCELLULAR LOCATION.
  • "Comparison of SDS- and methanol-assisted protein solubilization and digestion methods for Escherichia coli membrane proteome analysis by 2-D LC-MS/MS."
    Zhang N., Chen R., Young N., Wishart D., Winter P., Weiner J.H., Li L.
    Proteomics 7:484-493(2007) [PubMed] [Europe PMC] [Abstract]

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MLTFIELLIG VVVIVGVARY IIKGYSATGV LFVGGLLLLI ISAIMGHKVL 
        60         70         80         90        100
PSSQASTGYS ATDIVEYVKI LLMSRGGDLG MMIMMLCGFA AYMTHIGAND 
       110        120        130        140        150
MVVKLASKPL QYINSPYLLM IAAYFVACLM SLAVSSATGL GVLLMATLFP 
       160        170        180        190        200
VMVNVGISRG AAAAICASPA AIILAPTSGD VVLAAQASEM SLIDFAFKTT 
       210        220        230        240        250
LPISIAAIIG MAIAHFFWQR YLDKKEHISH EMLDVSEITT TAPAFYAILP 
       260        270        280        290        300
FTPIIGVLIF DGKWGPQLHI ITILVICMLI ASILEFLRSF NTQKVFSGLE 
       310        320        330        340        350
VAYRGMADAF ANVVMLLVAA GVFAQGLSTI GFIQSLISIA TSFGSASIIL 
       360        370        380        390        400
MLVLVILTML AAVTTGSGNA PFYAFVEMIP KLAHSSGINP AYLTIPMLQA 
       410        420        430        440        450
SNLGRTLSPV SGVVVAVAGM AKISPFEVVK RTSVPVLVGL VIVIVATELM 
       460 
VPGTAAAVTG K                                           

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. Escherichia coli
   Escherichia coli (strain K12): entries and cross-references to EcoGene