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UniProtKB - P0ABP3 (DCUC_ECOLI)

Entry version 99 (02 Jun 2021)
Sequence version 1 (08 Nov 2005)
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Protein

Anaerobic C4-dicarboxylate transporter DcuC

Gene

dcuC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Responsible for the transport of C4-dicarboxylates during anaerobic growth.

1 Publication

Caution

PubMed:8905232 and PubMed:16738553 sequences differ from that shown due to the presence of an IS5 insertion element between codons 327 and 328. Strain W3110A but not W3110B harbors this IS5 insertion.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

  • C4-dicarboxylate transport Source: EcoliWiki
  • mixed acid fermentation Source: EcoCyc
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:DCUC-MONOMER
MetaCyc:DCUC-MONOMER

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.61.1.1, the c4-dicarboxylate uptake c (dcuc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Anaerobic C4-dicarboxylate transporter DcuC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dcuC
Ordered Locus Names:b0621, JW0613/JW0616
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Transmembranei26 – 46HelicalSequence analysisAdd BLAST21
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Transmembranei267 – 287HelicalSequence analysisAdd BLAST21
Transmembranei313 – 333HelicalSequence analysisAdd BLAST21
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21
Transmembranei436 – 456HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002016271 – 461Anaerobic C4-dicarboxylate transporter DcuCAdd BLAST461

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P0ABP3

PRoteomics IDEntifications database

More...PRIDEi		P0ABP3

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		511145.b0621

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DcuC/DcuD transporter (TC 2.A.61) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG3069, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_030262_2_0_6

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004669, C4_dicarb_anaerob_car
IPR018385, C4_dicarb_anaerob_car-like

The PANTHER Classification System

More...PANTHERi		PTHR42002, PTHR42002, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03606, DcuC, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00771, DcuC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0ABP3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTFIELLIG VVVIVGVARY IIKGYSATGV LFVGGLLLLI ISAIMGHKVL 
        60         70         80         90        100
PSSQASTGYS ATDIVEYVKI LLMSRGGDLG MMIMMLCGFA AYMTHIGAND 
       110        120        130        140        150
MVVKLASKPL QYINSPYLLM IAAYFVACLM SLAVSSATGL GVLLMATLFP 
       160        170        180        190        200
VMVNVGISRG AAAAICASPA AIILAPTSGD VVLAAQASEM SLIDFAFKTT 
       210        220        230        240        250
LPISIAAIIG MAIAHFFWQR YLDKKEHISH EMLDVSEITT TAPAFYAILP 
       260        270        280        290        300
FTPIIGVLIF DGKWGPQLHI ITILVICMLI ASILEFLRSF NTQKVFSGLE 
       310        320        330        340        350
VAYRGMADAF ANVVMLLVAA GVFAQGLSTI GFIQSLISIA TSFGSASIIL 
       360        370        380        390        400
MLVLVILTML AAVTTGSGNA PFYAFVEMIP KLAHSSGINP AYLTIPMLQA 
       410        420        430        440        450
SNLGRTLSPV SGVVVAVAGM AKISPFEVVK RTSVPVLVGL VIVIVATELM 
       460 
VPGTAAAVTG K
Length:461
Mass (Da):48,412
Last modified:November 8, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD4042FBFE9F562ED
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA35263 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X99112 Genomic DNA Translation: CAA67561.1
U82598 Genomic DNA Translation: AAB40821.1
U00096 Genomic DNA Translation: AAC73722.1
AP009048 Genomic DNA Translation: BAA35264.1 Different termination.
AP009048 Genomic DNA Translation: BAA35263.1 Different initiation.

Protein sequence database of the Protein Information Resource

More...PIRi		C64796

NCBI Reference Sequences

More...RefSeqi		NP_415154.1, NC_000913.3
WP_000955063.1, NZ_STEB01000031.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC73722; AAC73722; b0621
BAA35263; BAA35263; BAA35263
BAA35264; BAA35264; BAA35264

Database of genes from NCBI RefSeq genomes

More...GeneIDi		61756005
945000

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW0613
ecj:JW0616
eco:b0621

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.1647

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99112 Genomic DNA Translation: CAA67561.1
U82598 Genomic DNA Translation: AAB40821.1
U00096 Genomic DNA Translation: AAC73722.1
AP009048 Genomic DNA Translation: BAA35264.1 Different termination.
AP009048 Genomic DNA Translation: BAA35263.1 Different initiation.
PIRiC64796
RefSeqiNP_415154.1, NC_000913.3
WP_000955063.1, NZ_STEB01000031.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi511145.b0621

Protein family/group databases

TCDBi2.A.61.1.1, the c4-dicarboxylate uptake c (dcuc) family

Proteomic databases

PaxDbiP0ABP3
PRIDEiP0ABP3

Genome annotation databases

EnsemblBacteriaiAAC73722; AAC73722; b0621
BAA35263; BAA35263; BAA35263
BAA35264; BAA35264; BAA35264
GeneIDi61756005
945000
KEGGiecj:JW0613
ecj:JW0616
eco:b0621
PATRICifig|1411691.4.peg.1647

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB3315

Phylogenomic databases

eggNOGiCOG3069, Bacteria
HOGENOMiCLU_030262_2_0_6

Enzyme and pathway databases

BioCyciEcoCyc:DCUC-MONOMER
MetaCyc:DCUC-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P0ABP3

Family and domain databases

InterProiView protein in InterPro
IPR004669, C4_dicarb_anaerob_car
IPR018385, C4_dicarb_anaerob_car-like
PANTHERiPTHR42002, PTHR42002, 1 hit
PfamiView protein in Pfam
PF03606, DcuC, 1 hit
TIGRFAMsiTIGR00771, DcuC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDCUC_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0ABP3
Secondary accession number(s): Q47134, Q9ZBC9, Q9ZBD0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: June 2, 2021
This is version 99 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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