UniProtKB - P0ABP3 (DCUC_ECOLI)
Protein
Anaerobic C4-dicarboxylate transporter DcuC
Gene
dcuC
Organism
Escherichia coli (strain K12)
Status
Functioni
Responsible for the transport of C4-dicarboxylates during anaerobic growth.1 Publication
Caution
PubMed:8905232 and PubMed:16738553 sequences differ from that shown due to the presence of an IS5 insertion element between codons 327 and 328. Strain W3110A but not W3110B harbors this IS5 insertion.Curated
GO - Molecular functioni
- succinate:fumarate antiporter activity Source: EcoCyc
GO - Biological processi
- C4-dicarboxylate transport Source: EcoliWiki
- mixed acid fermentation Source: EcoCyc
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:DCUC-MONOMER ECOL316407:JW0613-MONOMER ECOL316407:JW0616-MONOMER MetaCyc:DCUC-MONOMER |
Protein family/group databases
TCDBi | 2.A.61.1.1 the c4-dicarboxylate uptake c (dcuc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Anaerobic C4-dicarboxylate transporter DcuC |
Gene namesi | Name:dcuC Ordered Locus Names:b0621, JW0613/JW0616 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Cell inner membrane 1 Publication; Multi-pass membrane protein 1 Publication
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 2 – 22 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 26 – 46 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 79 – 99 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 116 – 136 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 137 – 157 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 164 – 184 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 199 – 219 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 240 – 260 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 267 – 287 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 313 – 333 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 343 – 363 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 436 – 456 | HelicalSequence analysisAdd BLAST | 21 |
GO - Cellular componenti
- integral component of plasma membrane Source: EcoCyc
- plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000201627 | 1 – 461 | Anaerobic C4-dicarboxylate transporter DcuCAdd BLAST | 461 |
Proteomic databases
PaxDbi | P0ABP3 |
PRIDEi | P0ABP3 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG4105CEE Bacteria COG3069 LUCA |
HOGENOMi | HOG000274996 |
KOi | K03326 |
Family and domain databases
InterProi | View protein in InterPro IPR004669 C4_dicarb_anaerob_car IPR018385 C4_dicarb_anaerob_car-like |
PANTHERi | PTHR42002 PTHR42002, 1 hit |
Pfami | View protein in Pfam PF03606 DcuC, 1 hit |
TIGRFAMsi | TIGR00771 DcuC, 1 hit |
i Sequence
Sequence statusi: Complete.
P0ABP3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLTFIELLIG VVVIVGVARY IIKGYSATGV LFVGGLLLLI ISAIMGHKVL
60 70 80 90 100
PSSQASTGYS ATDIVEYVKI LLMSRGGDLG MMIMMLCGFA AYMTHIGAND
110 120 130 140 150
MVVKLASKPL QYINSPYLLM IAAYFVACLM SLAVSSATGL GVLLMATLFP
160 170 180 190 200
VMVNVGISRG AAAAICASPA AIILAPTSGD VVLAAQASEM SLIDFAFKTT
210 220 230 240 250
LPISIAAIIG MAIAHFFWQR YLDKKEHISH EMLDVSEITT TAPAFYAILP
260 270 280 290 300
FTPIIGVLIF DGKWGPQLHI ITILVICMLI ASILEFLRSF NTQKVFSGLE
310 320 330 340 350
VAYRGMADAF ANVVMLLVAA GVFAQGLSTI GFIQSLISIA TSFGSASIIL
360 370 380 390 400
MLVLVILTML AAVTTGSGNA PFYAFVEMIP KLAHSSGINP AYLTIPMLQA
410 420 430 440 450
SNLGRTLSPV SGVVVAVAGM AKISPFEVVK RTSVPVLVGL VIVIVATELM
460
VPGTAAAVTG K
Sequence cautioni
The sequence BAA35263 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X99112 Genomic DNA Translation: CAA67561.1 U82598 Genomic DNA Translation: AAB40821.1 U00096 Genomic DNA Translation: AAC73722.1 AP009048 Genomic DNA Translation: BAA35264.1 Different termination. AP009048 Genomic DNA Translation: BAA35263.1 Different initiation. |
PIRi | C64796 |
RefSeqi | NP_415154.1, NC_000913.3 WP_000955063.1, NZ_STEB01000031.1 |
Genome annotation databases
EnsemblBacteriai | AAC73722; AAC73722; b0621 BAA35263; BAA35263; BAA35263 BAA35264; BAA35264; BAA35264 |
GeneIDi | 945000 |
KEGGi | ecj:JW0613 ecj:JW0616 eco:b0621 |
PATRICi | fig|1411691.4.peg.1647 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X99112 Genomic DNA Translation: CAA67561.1 U82598 Genomic DNA Translation: AAB40821.1 U00096 Genomic DNA Translation: AAC73722.1 AP009048 Genomic DNA Translation: BAA35264.1 Different termination. AP009048 Genomic DNA Translation: BAA35263.1 Different initiation. |
PIRi | C64796 |
RefSeqi | NP_415154.1, NC_000913.3 WP_000955063.1, NZ_STEB01000031.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 511145.b0621 |
Protein family/group databases
TCDBi | 2.A.61.1.1 the c4-dicarboxylate uptake c (dcuc) family |
Proteomic databases
PaxDbi | P0ABP3 |
PRIDEi | P0ABP3 |
Genome annotation databases
EnsemblBacteriai | AAC73722; AAC73722; b0621 BAA35263; BAA35263; BAA35263 BAA35264; BAA35264; BAA35264 |
GeneIDi | 945000 |
KEGGi | ecj:JW0613 ecj:JW0616 eco:b0621 |
PATRICi | fig|1411691.4.peg.1647 |
Organism-specific databases
EchoBASEi | EB3315 |
Phylogenomic databases
eggNOGi | ENOG4105CEE Bacteria COG3069 LUCA |
HOGENOMi | HOG000274996 |
KOi | K03326 |
Enzyme and pathway databases
BioCyci | EcoCyc:DCUC-MONOMER ECOL316407:JW0613-MONOMER ECOL316407:JW0616-MONOMER MetaCyc:DCUC-MONOMER |
Miscellaneous databases
PROi | PR:P0ABP3 |
Family and domain databases
InterProi | View protein in InterPro IPR004669 C4_dicarb_anaerob_car IPR018385 C4_dicarb_anaerob_car-like |
PANTHERi | PTHR42002 PTHR42002, 1 hit |
Pfami | View protein in Pfam PF03606 DcuC, 1 hit |
TIGRFAMsi | TIGR00771 DcuC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DCUC_ECOLI | |
Accessioni | P0ABP3Primary (citable) accession number: P0ABP3 Secondary accession number(s): Q47134, Q9ZBC9, Q9ZBD0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2005 |
Last sequence update: | November 8, 2005 | |
Last modified: | November 13, 2019 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene