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Entry version 108 (10 Feb 2021)
Sequence version 1 (08 Nov 2005)
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Protein

Anaerobic C4-dicarboxylate transporter DcuB

Gene

dcuB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:DCUB-MONOMER
MetaCyc:DCUB-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.13.1.2, the c4-dicarboxylate uptake (dcu) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Anaerobic C4-dicarboxylate transporter DcuB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dcuB
Synonyms:genF
Ordered Locus Names:b4123, JW4084
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1 – 19HelicalBy similarityAdd BLAST19
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20CytoplasmicBy similarity1
Transmembranei21 – 39HelicalBy similarityAdd BLAST19
Topological domaini40 – 55PeriplasmicBy similarityAdd BLAST16
Transmembranei56 – 73HelicalBy similarityAdd BLAST18
Topological domaini74 – 87CytoplasmicBy similarityAdd BLAST14
Transmembranei88 – 105HelicalBy similarityAdd BLAST18
Topological domaini106 – 134PeriplasmicBy similarityAdd BLAST29
Transmembranei135 – 149HelicalBy similarityAdd BLAST15
Topological domaini150 – 240CytoplasmicBy similarityAdd BLAST91
Transmembranei241 – 258HelicalBy similarityAdd BLAST18
Topological domaini259 – 275PeriplasmicBy similarityAdd BLAST17
Transmembranei276 – 293HelicalBy similarityAdd BLAST18
Topological domaini294 – 303CytoplasmicBy similarity10
Transmembranei304 – 321HelicalBy similarityAdd BLAST18
Topological domaini322 – 343PeriplasmicBy similarityAdd BLAST22
Transmembranei344 – 361HelicalBy similarityAdd BLAST18
Topological domaini362 – 366CytoplasmicBy similarity5
Transmembranei367 – 384HelicalBy similarityAdd BLAST18
Topological domaini385 – 446PeriplasmicBy similarityAdd BLAST62

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001703551 – 446Anaerobic C4-dicarboxylate transporter DcuBAdd BLAST446

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P0ABN9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0ABN9

PRoteomics IDEntifications database

More...
PRIDEi
P0ABN9

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4260911, 9 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b4123

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG2704, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_036056_1_1_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0ABN9

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0ABN9

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004668, Anaer_Dcu_memb_transpt

The PANTHER Classification System

More...
PANTHERi
PTHR36106, PTHR36106, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03605, DcuA_DcuB, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF004539, C4-dicrbxl_trns, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00770, Dcu, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0ABN9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLFTIQLIII LICLFYGARK GGIALGLLGG IGLVILVFVF HLQPGKPPVD
60 70 80 90 100
VMLVIIAVVA ASATLQASGG LDVMLQIAEK LLRRNPKYVS IVAPFVTCTL
110 120 130 140 150
TILCGTGHVV YTILPIIYDV AIKNNIRPER PMAASSIGAQ MGIIASPVSV
160 170 180 190 200
AVVSLVAMLG NVTFDGRHLE FLDLLAITIP STLIGILAIG IFSWFRGKDL
210 220 230 240 250
DKDEEFQKFI SVPENREYVY GDTATLLDKK LPKSNWLAMW IFLGAIAVVA
260 270 280 290 300
LLGADSDLRP SFGGKPLSMV LVIQMFMLLT GALIIILTKT NPASISKNEV
310 320 330 340 350
FRSGMIAIVA VYGIAWMAET MFGAHMSEIQ GVLGEMVKEY PWAYAIVLLL
360 370 380 390 400
VSKFVNSQAA ALAAIVPVAL AIGVDPAYIV ASAPACYGYY ILPTYPSDLA
410 420 430 440
AIQFDRSGTT HIGRFVINHS FILPGLIGVS VSCVFGWIFA AMYGFL
Length:446
Mass (Da):47,935
Last modified:November 8, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB4AF89BB2E0CCB3B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X79886 Genomic DNA Translation: CAA56258.1
U14003 Genomic DNA Translation: AAA97023.1
U00096 Genomic DNA Translation: AAC77084.1
AP009048 Genomic DNA Translation: BAE78125.1
M27058 Genomic DNA Translation: AAA23826.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S56352

NCBI Reference Sequences

More...
RefSeqi
NP_418547.1, NC_000913.3
WP_000899522.1, NZ_STEB01000014.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC77084; AAC77084; b4123
BAE78125; BAE78125; BAE78125

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
58459698
948641

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW4084
eco:b4123

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.2577

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79886 Genomic DNA Translation: CAA56258.1
U14003 Genomic DNA Translation: AAA97023.1
U00096 Genomic DNA Translation: AAC77084.1
AP009048 Genomic DNA Translation: BAE78125.1
M27058 Genomic DNA Translation: AAA23826.1
PIRiS56352
RefSeqiNP_418547.1, NC_000913.3
WP_000899522.1, NZ_STEB01000014.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4260911, 9 interactors
STRINGi511145.b4123

Protein family/group databases

TCDBi2.A.13.1.2, the c4-dicarboxylate uptake (dcu) family

Proteomic databases

jPOSTiP0ABN9
PaxDbiP0ABN9
PRIDEiP0ABN9

Genome annotation databases

EnsemblBacteriaiAAC77084; AAC77084; b4123
BAE78125; BAE78125; BAE78125
GeneIDi58459698
948641
KEGGiecj:JW4084
eco:b4123
PATRICifig|1411691.4.peg.2577

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0006

Phylogenomic databases

eggNOGiCOG2704, Bacteria
HOGENOMiCLU_036056_1_1_6
InParanoidiP0ABN9
PhylomeDBiP0ABN9

Enzyme and pathway databases

BioCyciEcoCyc:DCUB-MONOMER
MetaCyc:DCUB-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P0ABN9

Family and domain databases

InterProiView protein in InterPro
IPR004668, Anaer_Dcu_memb_transpt
PANTHERiPTHR36106, PTHR36106, 1 hit
PfamiView protein in Pfam
PF03605, DcuA_DcuB, 1 hit
PIRSFiPIRSF004539, C4-dicrbxl_trns, 1 hit
TIGRFAMsiTIGR00770, Dcu, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDCUB_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0ABN9
Secondary accession number(s): P14409, Q2M6I1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: February 10, 2021
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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