UniProtKB - P0ABM9 (CCMH_ECOLI)
Protein
Cytochrome c-type biogenesis protein CcmH
Gene
ccmH
Organism
Escherichia coli (strain K12)
Status
Functioni
May be required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 43 | Heme; covalentSequence analysis | 1 | |
Binding sitei | 46 | Heme; covalentSequence analysis | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- protein disulfide oxidoreductase activity Source: EcoCyc
GO - Biological processi
- cytochrome c-heme linkage via heme-L-cysteine Source: GO_Central
- cytochrome complex assembly Source: EcoCyc
Keywordsi
Biological process | Cytochrome c-type biogenesis |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12052-MONOMER MetaCyc:EG12052-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome c-type biogenesis protein CcmH |
Gene namesi | Name:ccmH Synonyms:yejP Ordered Locus Names:b2194, JW2182 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Plasma Membrane
- intrinsic component of periplasmic side of plasma membrane Source: EcoCyc
- plasma membrane Source: EcoCyc
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 19 – 96 | PeriplasmicSequence analysisAdd BLAST | 78 | |
Transmembranei | 97 – 119 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 120 – 146 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 147 – 169 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 170 – 350 | PeriplasmicSequence analysisAdd BLAST | 181 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000006612 | 19 – 350 | Cytochrome c-type biogenesis protein CcmHAdd BLAST | 332 |
Proteomic databases
jPOSTi | P0ABM9 |
PaxDbi | P0ABM9 |
PRIDEi | P0ABM9 |
Interactioni
Binary interactionsi
P0ABM9
With | #Exp. | IntAct |
---|---|---|
ccmF [P33927] | 3 | EBI-560309,EBI-763370 |
Protein-protein interaction databases
BioGRIDi | 4260481, 13 interactors |
ComplexPortali | CPX-3569, CcmFH system I cytochrome c biogenesis complex |
DIPi | DIP-48146N |
IntActi | P0ABM9, 5 interactors |
MINTi | P0ABM9 |
STRINGi | 511145.b2194 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 222 – 255 | TPR 1Add BLAST | 34 | |
Repeati | 293 – 326 | TPR 2Add BLAST | 34 |
Sequence similaritiesi
Belongs to the CcmH/CycL/Ccl2/NrfF family.Curated
Keywords - Domaini
Repeat, Signal, TPR repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG3088, Bacteria COG4235, Bacteria |
HOGENOMi | CLU_036074_0_0_6 |
Family and domain databases
Gene3Di | 1.10.8.640, 1 hit 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR005616, CcmH/CycL/Ccl2/NrfF IPR038297, CcmH/CycL/NrfF/Ccl2_sf IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF03918, CcmH, 1 hit |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50005, TPR, 2 hits PS50293, TPR_REGION, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P0ABM9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRFLLGVLML MISGSALATI DVLQFKDEAQ EQQFRQLTEE LRCPKCQNNS
60 70 80 90 100
IADSNSMIAT DLRQKVYELM QEGKSKKEIV DYMVARYGNF VTYDPPLTPL
110 120 130 140 150
TVLLWVLPVV AIGIGGWVIY ARSRRRVRVV PEAFPEQSVP EGKRAGYVVY
160 170 180 190 200
LPGIVVALIV AGVSYYQTGN YQQVKIWQQA TAQAPALLDR ALDPKADPLN
210 220 230 240 250
EEEMSRLALG MRTQLQKNPG DIEGWIMLGR VGMALGNASI ATDAYATAYR
260 270 280 290 300
LDPKNSDAAL GYAEALTRSS DPNDNRLGGE LLRQLVRTDH SNIRVLSMYA
310 320 330 340 350
FNAFEQQRFG EAVAAWEMML KLLPANDTRR AVIERSIAQA MQHLSPQESK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00008 Genomic DNA Translation: AAA16386.1 U00096 Genomic DNA Translation: AAC75254.1 AP009048 Genomic DNA Translation: BAE76657.1 |
PIRi | H64988 |
RefSeqi | NP_416698.1, NC_000913.3 WP_001211575.1, NZ_STEB01000002.1 |
Genome annotation databases
EnsemblBacteriai | AAC75254; AAC75254; b2194 BAE76657; BAE76657; BAE76657 |
GeneIDi | 58388765 946623 |
KEGGi | ecj:JW2182 eco:b2194 |
PATRICi | fig|1411691.4.peg.42 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00008 Genomic DNA Translation: AAA16386.1 U00096 Genomic DNA Translation: AAC75254.1 AP009048 Genomic DNA Translation: BAE76657.1 |
PIRi | H64988 |
RefSeqi | NP_416698.1, NC_000913.3 WP_001211575.1, NZ_STEB01000002.1 |
3D structure databases
BMRBi | P0ABM9 |
SMRi | P0ABM9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4260481, 13 interactors |
ComplexPortali | CPX-3569, CcmFH system I cytochrome c biogenesis complex |
DIPi | DIP-48146N |
IntActi | P0ABM9, 5 interactors |
MINTi | P0ABM9 |
STRINGi | 511145.b2194 |
Proteomic databases
jPOSTi | P0ABM9 |
PaxDbi | P0ABM9 |
PRIDEi | P0ABM9 |
Genome annotation databases
EnsemblBacteriai | AAC75254; AAC75254; b2194 BAE76657; BAE76657; BAE76657 |
GeneIDi | 58388765 946623 |
KEGGi | ecj:JW2182 eco:b2194 |
PATRICi | fig|1411691.4.peg.42 |
Organism-specific databases
EchoBASEi | EB1983 |
Phylogenomic databases
eggNOGi | COG3088, Bacteria COG4235, Bacteria |
HOGENOMi | CLU_036074_0_0_6 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12052-MONOMER MetaCyc:EG12052-MONOMER |
Miscellaneous databases
PROi | PR:P0ABM9 |
Family and domain databases
Gene3Di | 1.10.8.640, 1 hit 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR005616, CcmH/CycL/Ccl2/NrfF IPR038297, CcmH/CycL/NrfF/Ccl2_sf IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF03918, CcmH, 1 hit |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50005, TPR, 2 hits PS50293, TPR_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCMH_ECOLI | |
Accessioni | P0ABM9Primary (citable) accession number: P0ABM9 Secondary accession number(s): P33925, Q2MAP9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2005 |
Last sequence update: | November 8, 2005 | |
Last modified: | April 7, 2021 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families